GERD-Related Cough: Pathophysiology and Diagnostic Approach.

06:00 EDT 6th April 2011 | BioPortfolio

Summary of "GERD-Related Cough: Pathophysiology and Diagnostic Approach."

Chronic cough is a common problem resulting in significant impairment of quality of life. Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of cough. Despite this, acid suppression therapy is often far from effective. This review aims to explore whether reflux can lead to cough, the circumstances in which this is most likely to occur, and the potential mechanisms linking these processes. Particular mechanisms to be explored include laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization. Finally, diagnostic approaches are considered.


Respiratory Research Group, University of Manchester, ERC Building, Second Floor, Wythenshawe Hospital, Manchester, M23 9LT, UK,

Journal Details

This article was published in the following journal.

Name: Current gastroenterology reports
ISSN: 1534-312X


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