Advertisement

Topics

Molecular tweezers: concepts and applications.

Summary of "Molecular tweezers: concepts and applications."

Taken to the molecular level, the concept of "tweezers" opens a rich and fascinating field at the convergence of molecular recognition, biomimetic chemistry and nanomachines. Composed of a spacer bridging two interaction sites, the behaviour of molecular tweezers is strongly influenced by the flexibility of their spacer. Operating through an "induced-fit" recognition mechanism, flexible molecular tweezers select the conformation(s) most appropriate for substrate binding. Their adaptability allows them to be used in a variety of binding modes and they have found applications in chirality signalling. Rigid spacers, on the contrary, display a limited number of binding states, which lead to selective and strong substrate binding following a "lock and key" model. Exquisite selectivity may be expressed with substrates as varied as C(60) , nanotubes and natural cofactors, and applications to molecular electronics and enzyme inhibition are emerging. At the crossroad between flexible and rigid spacers, stimulus-responsive molecular tweezers controlled by ionic, redox or light triggers belong to the realm of molecular machines, and, applied to molecular tweezing, open doors to the selective binding, transport and release of their cargo. Applications to controlled drug delivery are already appearing. The past 30 years have seen the birth of molecular tweezers; the next many years to come will surely see them blooming in exciting applications.

Affiliation

Faculté de Pharmacie, Université de Montréal, PO Box 6128 Downtown Station, Montréal, QC, H3C 3J7 (Canada).

Journal Details

This article was published in the following journal.

Name: Chemphyschem : a European journal of chemical physics and physical chemistry
ISSN: 1439-7641
Pages: 1043-51

Links

DeepDyve research library

PubMed Articles [16740 Associated PubMed Articles listed on BioPortfolio]

Six states switching of redox-active molecular tweezers by three orthogonal stimuli.

A six level molecular switch based on terpyridine(Ni-salphen)2 tweezers and addressable by three orthogonal stimuli (metal coordination, redox reaction and guest binding) is reported. By a metal coord...

Applications of Magnetic Tweezers to Studies of NAPs.

Nucleoid-associated proteins (NAPs) are important factors in shaping bacterial nucleoid and regulating global gene expression. A great deal of insights into NAPs can be obtained through studies using ...

Molecular Gels as Intermediates in the Synthesis of Porous Materials and Fluorescent Films: Concepts and Applications.

Low Molecular-Mass Organic Gelator (LMOG)-based molecular gels are known as one of the most attractive soft materials and have received great attention since the early 1990s. In the last few decades, ...

Can the Aviation Industry be Useful in Teaching Oncology about Safety?

Healthcare practitioners have long considered aviation as a domain from which much can be learned about safety. Over the past 30 years, attempts have been made to apply aviation safety-related concept...

Optical tweezers studies of transcription by eukaryotic RNA polymerases.

Transcription is the first step in the expression of genetic information and it is carried out by large macromolecular enzymes called RNA polymerases. Transcription has been studied for many years and...

Clinical Trials [1408 Associated Clinical Trials listed on BioPortfolio]

Smartphone Application-Based Vital Sign Monitors

Health-related applications for smartphones represent a new and popular market for consumer oriented products. These applications are generally not considered medical devices and, as such,...

Cessation of Tyrosine Kinase Inhibitors in Patients With Chronic-phase Chronic Myelogenous Leukaemia

Since the debut of imatinib, the first tyrosine kinase inhibitor(TKI), more than two decades ago, the prognosis of patients with chronic myelogenous leukaemia (CML) has continued to improv...

Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation

The objectives of this study are: - To compare the change in levels of tear proteins and inflammatory mediators pre and post administration between the intranasal and extranasal a...

Comparison of Different Massage Techniques Plus Conservative Applications in Low Back Pain

The aim of this study is to compare of different massage techniques plus conservative aplications in low back pain treatment.

Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation

Demonstrate the impact of the Molecular Microscope Diagnostic System as the standard of care for heart transplant patients.

Medical and Biotech [MESH] Definitions

Structured vocabularies describing concepts from the fields of biology and relationships between concepts.

A technique that uses LASERS to trap, image, and manipulate small objects (biomolecules, supramolecular assembles, DENDRIMERS) in three dimensional space. (From Glossary of Biotechnology and Nanobiotechnology Terms, 4th ed.)

A methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for molecularly imprinted polymers (MIPs) include separations, assays and biosensors, and catalysis.

The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.

The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Enzymes
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...

Pharmacy
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...


Searches Linking to this Article