Track topics on Twitter Track topics that are important to you
Taken to the molecular level, the concept of "tweezers" opens a rich and fascinating field at the convergence of molecular recognition, biomimetic chemistry and nanomachines. Composed of a spacer bridging two interaction sites, the behaviour of molecular tweezers is strongly influenced by the flexibility of their spacer. Operating through an "induced-fit" recognition mechanism, flexible molecular tweezers select the conformation(s) most appropriate for substrate binding. Their adaptability allows them to be used in a variety of binding modes and they have found applications in chirality signalling. Rigid spacers, on the contrary, display a limited number of binding states, which lead to selective and strong substrate binding following a "lock and key" model. Exquisite selectivity may be expressed with substrates as varied as C(60) , nanotubes and natural cofactors, and applications to molecular electronics and enzyme inhibition are emerging. At the crossroad between flexible and rigid spacers, stimulus-responsive molecular tweezers controlled by ionic, redox or light triggers belong to the realm of molecular machines, and, applied to molecular tweezing, open doors to the selective binding, transport and release of their cargo. Applications to controlled drug delivery are already appearing. The past 30 years have seen the birth of molecular tweezers; the next many years to come will surely see them blooming in exciting applications.
Faculté de Pharmacie, Université de Montréal, PO Box 6128 Downtown Station, Montréal, QC, H3C 3J7 (Canada).
This article was published in the following journal.
Name: Chemphyschem : a European journal of chemical physics and physical chemistry
Trimethylammonium-derived alkynylplatinum(II) terpyridine molecular tweezers have been designed and synthesized in this manuscript. They show moderate binding affinity towards the complementary organo...
The observation of biological processes at the molecular scale in real time requires high spatial and temporal resolution. Magnetic tweezers are straightforward to implement, free of radiation or phot...
This review summarizes part of the author's research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially mol...
Keystone flaps demonstrated growing clinical applications in reconstructive surgery in the last decade. This paper highlights flap modifications and their versatility for clinical applications and man...
There is clearly a plurality of forms of altruism. Classically, biological altruism is distinguished from psychological altruism. Recent discussions of altruism have attempted to distinguish even more...
Health-related applications for smartphones represent a new and popular market for consumer oriented products. These applications are generally not considered medical devices and, as such,...
The objectives of this study are: - To compare the change in levels of tear proteins and inflammatory mediators pre and post administration between the intranasal and extranasal a...
The aim of this study is to compare of different massage techniques plus conservative aplications in low back pain treatment.
Demonstrate the impact of the Molecular Microscope Diagnostic System as the standard of care for heart transplant patients.
Purpose of the Protocol: - To prospectively identify cancer patients whose tumors express specific molecular markers targeted by therapeutic agents, for the purpose of selecting t...
A technique that uses LASERS to trap, image, and manipulate small objects (biomolecules, supramolecular assembles, DENDRIMERS) in three dimensional space. (From Glossary of Biotechnology and Nanobiotechnology Terms, 4th ed.)
A methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for molecularly imprinted polymers (MIPs) include separations, assays and biosensors, and catalysis.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
Evolution at the molecular level of DNA sequences and proteins. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...