Meaningful Placebos - Controlling the Uncontrollable.
Summary of "Meaningful Placebos - Controlling the Uncontrollable."
In this issue of the Journal, Wechsler et al.(1) report data from a study that compared four interventions involving patients with asthma (ClinicalTrials.gov number, NCT01143688). They found that three of the interventions - active albuterol, sham albuterol, and sham acupuncture - were all equally effective in controlling asthma symptoms, as judged by patient-reported improvement. In contrast, lung function was improved only in those given active albuterol, as measured by an increase in the forced expiratory volume in 1 second (FEV(1)). The fourth intervention was "no treatment," in which patients were told to wait for several hours and then . . .
From the University of Michigan-Dearborn, Dearborn.
This article was published in the following journal.
Name: The New England journal of medicine
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21751911
- DOI: http://dx.doi.org/10.1056/NEJMe1104010
Medical and Biotech [MESH] Definitions
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.
The enhancement of physical, cognitive, emotional and social skills so an individual may participate in chosen activities. Recreational modalities are used in designed intervention strategies, incorporating individual's interests to make the therapy process meaningful and relevant.
Soft Tissue Injuries
Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as "soft tissue injuries of the hand".
Methods for controlling genetic SEX of offspring. It may include SEX DETERMINATION (GENETICS) and other means.
Aim: The World Medical Association Declaration of Helsinki states that the use of a placebo in a clinical trial can only be justified ethically when no proven active treatment is available as a com...
Background: No regulations govern placebo composition. The composition of placebos can influence trial outcomes and merits reporting. Purpose: To assess how often investigators specify the composition...
This study aimed to determine the amount of water required for ingesting an orally disintegrating tablet (ODT) of solifenacin (Vesicare(®), VES) and VES conventional tablets (VES-CT). We measured the...
This study aims at comparing the efficacy and safety of recombinant human activated protein C to that of low dose of corticosteroids and at investigating the interaction between these drug...
RATIONALE: Giving medications in different ways may change their effectiveness in controlling pain. It is not yet known whether intrathecal therapy is more effective than standard therapy...
The goal of this project is to pilot-test an instrument that is designed to assess the relationship between persons who use controlling behavior with intimate partners, as a risk factor fo...
Some people who are exposed to the HIV-1 virus are capable of either controlling or completely preventing viral infection. Multiple genetic factors may contribute to preventing or controll...
To develop and implement asthma-controlling educational strategies for inner city and high risk populations.