Sarcopenia - pathophysiology and clinical relevance.

05:48 EDT 20th October 2014 | BioPortfolio

Summary of "Sarcopenia - pathophysiology and clinical relevance."

The causes of sarcopenia are multidimensional. The loss of fast-twitch muscle fibres exceeds the loss of slow-twitch muscle fibres and ends as a clinical relevant loss of muscle power. On a sub-cellular level, age associated changes in the mitochondria lead to functional decline of the muscle. The reduction of motor units causes muscle fibre atrophy and loss of muscle strength. Low levels of anabolic hormones and the imbalance of pro- and anti-inflammatory cytokines are responsible for changes in body composition of older adults. Reduced levels of physical activity, vitamin D and protein are highly associated with muscle loss. Sarcopenia causes loss of independence and high medical and nursing needs resulting in great economic healthcare burden.

Affiliation

Institute for Biomedicine of Aging, University of Erlangen-Nürnberg, Nürnberg, Germany, michael.drey@gmx.de.

Journal Details

This article was published in the following journal.

Name: Wiener medizinische Wochenschrift (1946)
ISSN: 1563-258X
Pages:

Links

PubMed Articles [18991 Associated PubMed Articles listed on BioPortfolio]

Sarcopenia: Definition, Epidemiology, and Pathophysiology.

The epidemiological trends that characterize our generation are the aging of the population. Aging results in a progressive loss of muscle mass and strength called sarcopenia, which is Greek for 'pove...

Sarcopenia as a Predictor for Complications and Survival Following Radical Cystectomy.

Patients undergoing radical cystectomy face substantial-but highly variable-risks of major complications. Risk stratification may be enhanced by objective measures such as sarcopenia. Sarcopenia, the ...

Sarcopenia: the new definitions.

To highlight the new international definitions of sarcopenia.

Sarcopenia and its relationship with osteoarthritis: risk factor or direct consequence?

The aim of this review is to evaluate the clinical role of sarcopenia in patients affected by osteoarthritis (OA) of major joints.

Interaction between Muscle and Bone.

The clinical significance of sarcopenia and osteoporosis has increased with the increase in the population of older people. Sarcopenia is defined by decreased muscle mass and impaired muscle function,...

Clinical Trials [1146 Associated Clinical Trials listed on BioPortfolio]

Nutrition and Exercise for Sarcopenia

The investigators' general hypothesis is that nutritional factors, including protein/energy malnutrition and/or an impaired response of muscle to nutrition, and inactivity play significant...

Insulin and Sarcopenia in the Elderly

Muscle loss with aging is a significant contributor to disability in older people. Our general hypothesis is that loss of muscle with aging, known as sarcopenia, may be due to inability of...

Protein Synthesis in Midthigh Muscles PET/CT

The purpose of this study is to test a new imaging technique to help scientists study sarcopenia, the process by which muscle becomes weaker with age.

Sarcopenia Studies for the Elderly Population in Taiwan

Health promotion in the elderly has been a major recent public health concern. Sarcopenia is a term utilized to define the loss of muscle mass and strength that occurs with aging. It has b...

Study The Safety and Efficacy of MK0773 in Women With Sarcopenia (Loss of Muscle Mass)

A study to evaluate the safety, tolerability, and efficacy of MK0773 in women with sarcopenia (loss of muscle mass).

Medical and Biotech [MESH] Definitions

Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles.

Research using processes by which the reliability and relevance of a procedure for a specific purpose are established.

Works consisting of research using processes by which the reliability and relevance of a procedure for a specific purpose are established.

Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

Work that consists of a conference of physicians on their observations of a patient at the bedside, regarding the physical state, laboratory and other diagnostic findings, clinical manifestations, results of current therapy, etc. A clinical conference usually ends with a confirmation or correction of clinical findings by a pathological diagnosis performed by a pathologist. "Clinical conference" is often referred to as a "clinico-pathological conference."

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Rheumatology
Latest News Clinical Trials Research Drugs Reports Corporate
Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Dictionary). It is an active area of medical research, because of the d...

Dermatology
Latest News Clinical Trials Research Drugs Reports Corporate
Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers a range of diseases including skin allergies, alopecia, Behcet'...

Advertisement