Advertisement

Topics

Sarcopenia - pathophysiology and clinical relevance.

Summary of "Sarcopenia - pathophysiology and clinical relevance."

The causes of sarcopenia are multidimensional. The loss of fast-twitch muscle fibres exceeds the loss of slow-twitch muscle fibres and ends as a clinical relevant loss of muscle power. On a sub-cellular level, age associated changes in the mitochondria lead to functional decline of the muscle. The reduction of motor units causes muscle fibre atrophy and loss of muscle strength. Low levels of anabolic hormones and the imbalance of pro- and anti-inflammatory cytokines are responsible for changes in body composition of older adults. Reduced levels of physical activity, vitamin D and protein are highly associated with muscle loss. Sarcopenia causes loss of independence and high medical and nursing needs resulting in great economic healthcare burden.

Affiliation

Institute for Biomedicine of Aging, University of Erlangen-Nürnberg, Nürnberg, Germany, michael.drey@gmx.de.

Journal Details

This article was published in the following journal.

Name: Wiener medizinische Wochenschrift (1946)
ISSN: 1563-258X
Pages:

Links

DeepDyve research library

PubMed Articles [21752 Associated PubMed Articles listed on BioPortfolio]

Sarcopenia and liver transplant: The relevance of too little muscle mass.

Loss of muscle mass and function is a common occurrence in both patients with decompensated cirrhosis and those undergoing liver transplantation. Sarcopenia is associated with morbidity and mortality ...

Sarcopenia in critically ill patients.

Sarcopenia occurring as a primary consequence of aging and secondary due to certain medical problems including chronic disease, malnutrition and inactivity is a progressive generalized loss of skeleta...

Continuous urethral pressure measurements; measurement techniques; pressure variations; clinical interpretations; and clinical relevance. A Systematic Literature Analysis.

The clinical relevance of urethral pressure variations (UPV) in the pathophysiology of over active bladder syndrome (OAB) has remained controversial to date. Some studies report an association with OA...

Cardiac cachexia: hic et nunc.

Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenge...

Sarcopenia and mortality among a population-based sample of community-dwelling older adults.

Sarcopenia is a risk-factor for all-cause mortality among older adults, but it is unknown if sarcopenia predisposes older adults to specific causes of death. Further, it is unknown if the prognostic r...

Clinical Trials [1612 Associated Clinical Trials listed on BioPortfolio]

Clinical Trial to Assess the Preventive Effects of Cetylpyridinium Chloride on Sarcopenia

This study is to assess the impact on the prevention of sarcopenia after taking cetylpyridinium chloride targeting the patients of pre-sarcopenia or sarcopenia over the age of 60

Measurement of Sarcopenia at Post-stroke Rehabilitation Outcome

The purposes of this study are 1. To explore effect of sarcopenia on recovery of post stroke hemiplegia 2. To explore the effect of stroke on sarcopenia and relationship between the ...

Prevalence of Sarcopenia and Its Geriatric Features

The goal of this study is to determine the prevalence of sarcopenia in a geriatric hospital ward. Sarcopenia is defined by a loss of muscle mass, loss of muscle strength and loss of muscl...

ERAS in Colorectal Surgery Diminishes the Negative Impact of Sarcopenia on Short Term Outcomes

So far, the impact of sarcopenia has been analysed only in patients undergoing traditional surgical procedures (laparotomy) or those with metastatic spread. As the ERAS protocol combined w...

Detection and Treatment of Sarcopenia and Myosteatosis in Older African Americans

The objectives of this study are to: 1) validate a rapid, portable, cost-effective method for screening myosteatosis and sarcopenia using diagnostic ultrasound, and 2) investigate a novel ...

Medical and Biotech [MESH] Definitions

Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles.

Research using processes by which the reliability and relevance of a procedure for a specific purpose are established.

Works consisting of research using processes by which the reliability and relevance of a procedure for a specific purpose are established.

Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

Work that consists of a conference of physicians on their observations of a patient at the bedside, regarding the physical state, laboratory and other diagnostic findings, clinical manifestations, results of current therapy, etc. A clinical conference usually ends with a confirmation or correction of clinical findings by a pathological diagnosis performed by a pathologist. "Clinical conference" is often referred to as a "clinico-pathological conference."

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

Dermatology
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Article