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To determine an optimal b value to visualise prostate cancer using diffusion-weighted magnetic resonance imaging at 3 T.
Forty one patients with biopsy proven prostate cancer underwent 3 T diffusion-weighted MRI performed with 5 b values (0, 1,000, 1,500, 2,000, 2,500 s/mm(2)) using a 16-channel coil. Best lesion visibility, the central gland-lesion (CG-L) and the peripheral zone-lesion (PZ-L) contrast-to-noise ratio (CNR) were compared between different b value images, apparent diffusion coefficient (ADC) were measured. In a subset of 29 patients a high resolution b1,500 s/mm(2)diffusion-weighted sequence was additionally assessed.
The b = 1,500 s/mm(2) and b = 2,000 s/mm(2) images provided the best lesion visibility respectively in 27/41 and in 10/41patients. The highest CG-L and PZ-L CNR were obtained with b = 1,500 s/mm(2) (P < 0.0001). The mean ADC value calculated from 0 to 1,500 s/mm(2) b values in cancer lesions (ADC = 736 ± 173 10(-6) mm(2)/s) was statistically significantly lower than in the peripheral zone (ADC = 1,338 ± 256 10(-6) mm(2)/s, P < 0.0001) and in the central gland (ADC = 1,270 ± 239 10(-6) mm(2)/s, P < 0.0001). The high resolution diffusion sequence was judged of better lesion visibility than (17/29) or equivalent to (6/29) the best images from the 5b sequence.
At 3 T, prostate cancer lesions are best depicted with b = 1,500 s/mm(2) and b = 2,000 s/mm(2) images, b = 1,500 s/mm(2) high-resolution diffusion images improve the image quality and contrast. KEY POINTS : • Multiple b ≥ 1,000 s/mm ( 2 ) 3 T-DW Magnetic Resonance Imaging provides excellent prostate cancer depiction. • Prostate DWI and ADC maps are attainable at 3 T without endorectal coil. • Prostate cancer depiction is improved on high resolution b 1,500 s/mm ( 2 ) 3 T-DWI.
Resonance Magnetique, Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Bruxelles, Belgique, Belgium, firstname.lastname@example.org.
This article was published in the following journal.
Name: European radiology
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The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
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