What is the optimal b value in diffusion-weighted MR imaging to depict prostate cancer at 3T?

22:49 EDT 24th October 2014 | BioPortfolio

Summary of "What is the optimal b value in diffusion-weighted MR imaging to depict prostate cancer at 3T?"


OBJECTIVE:
To determine an optimal b value to visualise prostate cancer using diffusion-weighted magnetic resonance imaging at 3 T.
METHODS:
Forty one patients with biopsy proven prostate cancer underwent 3 T diffusion-weighted MRI performed with 5 b values (0, 1,000, 1,500, 2,000, 2,500 s/mm(2)) using a 16-channel coil. Best lesion visibility, the central gland-lesion (CG-L) and the peripheral zone-lesion (PZ-L) contrast-to-noise ratio (CNR) were compared between different b value images, apparent diffusion coefficient (ADC) were measured. In a subset of 29 patients a high resolution b1,500 s/mm(2)diffusion-weighted sequence was additionally assessed.
RESULTS:
The b = 1,500 s/mm(2) and b = 2,000 s/mm(2) images provided the best lesion visibility respectively in 27/41 and in 10/41patients. The highest CG-L and PZ-L CNR were obtained with b = 1,500 s/mm(2) (P < 0.0001). The mean ADC value calculated from 0 to 1,500 s/mm(2) b values in cancer lesions (ADC = 736 ± 173 10(-6) mm(2)/s) was statistically significantly lower than in the peripheral zone (ADC = 1,338 ± 256 10(-6) mm(2)/s, P < 0.0001) and in the central gland (ADC = 1,270 ± 239 10(-6) mm(2)/s, P < 0.0001). The high resolution diffusion sequence was judged of better lesion visibility than (17/29) or equivalent to (6/29) the best images from the 5b sequence.
CONCLUSION:
At 3 T, prostate cancer lesions are best depicted with b = 1,500 s/mm(2) and b = 2,000 s/mm(2) images, b = 1,500 s/mm(2) high-resolution diffusion images improve the image quality and contrast. KEY POINTS : • Multiple b ≥ 1,000 s/mm ( 2 ) 3 T-DW Magnetic Resonance Imaging provides excellent prostate cancer depiction. • Prostate DWI and ADC maps are attainable at 3 T without endorectal coil. • Prostate cancer depiction is improved on high resolution b 1,500 s/mm ( 2 ) 3 T-DWI.

Affiliation

Resonance Magnetique, Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Bruxelles, Belgique, Belgium, tmetens@ulb.ac.be.

Journal Details

This article was published in the following journal.

Name: European radiology
ISSN: 1432-1084
Pages:

Links

PubMed Articles [12561 Associated PubMed Articles listed on BioPortfolio]

Parametrial Invasion in Cervical Cancer: Fused T2-weighted Imaging and High-b-Value Diffusion-weighted Imaging with Background Body Signal Suppression at 3 T.

Purpose To retrospectively investigate the value of fused T2-weighted and high-b-value diffusion-weighted imaging with background body signal suppression ( DWIBS diffusion-weighted whole-body imaging ...

The correlation between MR diffusion-weighted imaging and pathological grades on glioma.

This work intends to quantitatively analyze on pathological grade of glioma using Magnetic Resonance (MR) diffusion weighted imaging (DWI) and exploring the relativity of pathological grade and Appare...

Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm(2) : Correlation with Gleason score and repeatability of region of interest analysis.

To evaluate four mathematical models for diffusion weighted imaging (DWI) of prostate cancer (PCa) in terms of PCa detection and characterization.

Magnetic Resonance Colonography Including Diffusion-Weighted Imaging in Children and Adolescents With Inflammatory Bowel Disease: Do We Really Need Intravenous Contrast?

Magnetic resonance colonography (MRC) is a well-accepted, noninvasive imaging modality for the depiction of inflammatory bowel disease. Diffusion-weighted imaging (DWI) is very helpful to display infl...

MRI in Prostate Cancer.

Imaging studies play an important role in detection and management of prostate cancer and MRI especially with the use of endorectal coil because of high contrast resolution is recognized as the best i...

Clinical Trials [3117 Associated Clinical Trials listed on BioPortfolio]

Diffusion-Weighted MRI in Staging Patients With Localized Prostate Cancer

This pilot clinical trial studies how well diffusion-weighted magnetic resonance imaging (MRI) works in staging patients with prostate cancer that has not spread to nearby lymph nodes or o...

Efficacy of Non Contrast DWI(Diffusion Weighted Imaging) Imaging Compared to DMR-DE

To discover new information about MRI(magnetic resonance imaging)called DWI (diffusion weighted imaging) and its ability to diagnose cardiac scarring. CMR-DE (cardiac magnetic resonance w...

MRI (Including Spectroscopy and Fat-Saturations and Diffusion-Weighted Imaging) in Cervical Cancer

To detect differences in MR spectroscopy, diffusion weighted MR, or dynamic contrast enhancement (DCE) MR imaging between primary cervical tumors and normal cervical tissue.

Defining the Extent and Grade of Prostate Cancer Using Dynamic Contrast Enhanced Diffusion Weighted and BOLD MRI

The purpose of this study is to determine the ability of functional MRI techniques [High Resolution Dynamic Contrast Enhanced MRI (HR-DCE-MRI), diffusion weighted MRI (DWI) and BOLD MRI] t...

Whole Body Magnetic Resonance Imaging (MRI) for Detection of Cancer Metastases

The objective of this pilot study is to develop and evaluate a whole body MRI technique for detecting cancer metastases. The whole body MRI will include T1-weighted and T2-weighted phase-...

Medical and Biotech [MESH] Definitions

The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.

A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.

The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.

Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.

A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.

Search BioPortfolio:
Loading
Advertisement

Relevant Topic

Cancer
Latest News Clinical Trials Research Drugs Reports Corporate
Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs.  Cancer sometimes begins in one part of the body before spre...

Advertisement