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Clinical presentations following the use of various "spice" or synthetic cannabinoids have included agitation, anxiety, emesis, hallucinations, psychosis, tachycardia, and unresponsiveness. Convulsions were described in a one report although there was not laboratory confirmation for synthetic cannabinoids. In another published report laboratory confirmation for a synthetic cannabinoid was done in which the patient manifested activity that was interpreted as a possible convulsion. CASE
We describe a patient who had two witnessed generalized convulsions soon after smoking a "spice" product that we later confirmed to have four different synthetic cannabinoids.
Convulsions have only rarely been associated with marijuana exposures. Recreational use of synthetic cannabinoids is a very recent phenomenon and there is a very limited, albeit burgeoning, literature detailing the associated complications including convulsions we have reported here. The absence of anticonvulsant phytocannabinoids in spice products could potentially be one of multiple unknown mechanisms contributing to convulsions.
Division of Medical Toxicology, Department of Emergency Medicine, University of California, San Diego Medical Center, 200 West Arbor Drive #8925, San Diego, CA, 92103, USA, email@example.com.
This article was published in the following journal.
Name: Journal of medical toxicology : official journal of the American College of Medical Toxicology
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Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.
Compounds that inhibit or block the activity of CANNABINOID RECEPTORS.
Compounds that interact with and stimulate the activity of CANNABINOID RECEPTORS.
A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.
A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.
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