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Following evolution of bacterial antibiotic resistance in real time.

10:49 EDT 29th July 2014 | BioPortfolio

Summary of "Following evolution of bacterial antibiotic resistance in real time."

A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.

Affiliation

Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California, USA.

Journal Details

This article was published in the following journal.

Name: Nature genetics
ISSN: 1546-1718
Pages: 11-3

Links

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Medical and Biotech [MESH] Definitions

Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.

The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

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