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Following evolution of bacterial antibiotic resistance in real time.

06:00 EST 28th December 2011 | BioPortfolio

Summary of "Following evolution of bacterial antibiotic resistance in real time."

A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.

Affiliation

Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California, USA.

Journal Details

This article was published in the following journal.

Name: Nature genetics
ISSN: 1546-1718
Pages: 11-3

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An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

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