Lamotrigine in the Treatment of Unipolar Depression with and Without Comorbidities: A Literature Review.

01:28 EDT 25th May 2015 | BioPortfolio

Summary of "Lamotrigine in the Treatment of Unipolar Depression with and Without Comorbidities: A Literature Review."

To review the available data behind the use of lamotrigine in unipolar depression and common comorbid conditions. A PubMed based literature review was conducted using keywords related to lamotrigine, depression, anxiety, post traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and personality disorders. A large number of trials using lamotrigine for unipolar depression and various comorbid conditions were reviewed. A major limitation behind the majority of studies was a limited course of the treatment phase. The most robust data was found among studies that followed patients for over 8 weeks, and used higher dosages. Patients with comorbid anxiety states appeared to benefit. Patients with borderline personality disorder also appeared to benefit. The benefits of lamotrigine in unipolar depression have been inconsistently noted in a number of studies. This is due in part to short treatment phases, atypical domains of benefit and different patient populations across studies. Patients with more treatment-resistance, comorbid anxiety and borderline personality disorder may be more able to benefit from lamotrigine.

Affiliation

Department of Psychiatry and Behavioral Medicine, Carilion Clinic-Virginia Tech Carilion School of Medicine, Roanoke, VA, USA, adzavodnick@carilionclinic.org.

Journal Details

This article was published in the following journal.

Name: The Psychiatric quarterly
ISSN: 1573-6709
Pages:

Links

PubMed Articles [23176 Associated PubMed Articles listed on BioPortfolio]

Differential diagnosis of unipolar vs bipolar depression.

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Brain Morphometric Biomarkers Distinguishing Unipolar and Bipolar Depression: A Voxel-Based Morphometry-Pattern Classification Approach.

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Bipolar depression (BD) is characterized by alternating episodes of depression and mania. Patients who spend the majority of their time in episodes of depression rather than mania are often misdiagnos...

Risk factors for treatment resistance in unipolar depression: A systematic review.

Treatment resistant depression is a complex disorder and an important source of morbidity and mortality. Identification of risk factors of resistance may be useful to improve early recognition as well...

Clinical Trials [1968 Associated Clinical Trials listed on BioPortfolio]

Lamotrigine Augmentation in Resistant Depression

This study is intended to evaluate the efficacy and safety of lamotrigine as an antidepressant augmentation agent in a sample of individuals with major depression and a history of both pri...

Lamotrigine for Symptoms of Geriatric Bipolar Depression

This is a 12-week, open label trial of lamotrigine for older adults (age 60 and older) with type I or type II Bipolar depression. Non-demented older adults with Bipolar I or II depressio...

Lamotrigine Alone Compared to Lamotrigine Plus Antidepressant for the Treatment of Bipolar II Depression

Depression is a medical condition characterized by feeling sad even when good things happen, having low energy and motivation, and sometimes even experiencing suicidal thoughts. Bipolar II...

Natural Supplements for Unipolar Depression

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RCT of Psychoeducational Program of Depression

The purpose of the study is to test the efficacy of a psychoeducational group program on unipolar depression

Medical and Biotech [MESH] Definitions

An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)

Decompression external to the body, most often the slow lessening of external pressure on the whole body (especially in caisson workers, deep sea divers, and persons who ascend to great heights) to prevent DECOMPRESSION SICKNESS. It includes also sudden accidental decompression, but not surgical (local) decompression or decompression applied through body openings.

Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)

Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.

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