Development of immunization trials against Klebsiella pneumoniae.
Summary of "Development of immunization trials against Klebsiella pneumoniae."
Klebsiella pneumoniae is the most common cause of nosocomial respiratory tract and premature intensive care infections, and the second most frequent cause of Gram-negative bacteraemia and urinary tract infections. Drug resistant isolates remain an important hospital-acquired bacterial pathogen, add significantly to hospital stays, and are especially problematic in high impact medical areas such as intensive care units. Many investigations worldwide proved the increasing resistance of such pathogen, resulting in an average rate of 1.63 outbreak every year. A variety of preventive measures were applied to reduce such incidences. Immunotherapy and passive immunization researches as well found their way to the treatment of Klebsiella. During the last 40 years, many trials for constructing effective vaccines were followed. This up-to-date review classifies such trials and documents them in a progressive way. A following comment discusses each group benefits and defects.
Affiliation
Biotechnology Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
Journal Details
This article was published in the following journal.
Name: Vaccine
ISSN: 1873-2518
Pages: 2411-20
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22100884
- DOI: http://dx.doi.org/10.1016/j.vaccine.2011.11.027
Medical and Biotech [MESH] Definitions
Klebsiella Pneumoniae
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Enterobacter Aerogenes
Gram-negative, capsulated, gas-producing rods found widely in nature. Both motile and non-motile strains exist. The species is closely related to KLEBSIELLA PNEUMONIAE and is frequently associated with nosocomial infections
Immunization, Secondary
Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.
Klebsiella Infections
Infections with bacteria of the genus KLEBSIELLA.
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
PubMed Articles
Draft Genome Sequence of Klebsiella pneumoniae subsp. pneumoniae DSM 30104T.
Klebsiella pneumoniae is a Gram-negative, rod-shaped, nonmotile, and opportunistic pathogenic species with clinical importance. It is a part of natural flora of humans and animals. Here we report the...
Community-acquired Klebsiella pneumoniae liver abscess: an emerging infection in Ireland and Europe.
INTRODUCTION: Klebsiella pneumoniae has emerged as a predominant cause of community-acquired mono-microbial pyogenic liver abscess. This was first described in Taiwan and has been widely reported in A...
We describe the investigation and control of a Klebsiella pneumoniae carbapenemase-producing K. pneumoniae outbreak in a 20-bed surgical intensive care unit during the period from January 1, 2009 thro...
Inhibition of Klebsiella Pneumoniae DnaB Helicase by the Flavonol Galangin.
Klebsiella pneumoniae is a ubiquitous opportunistic pathogen that colonizes at the mucosal surfaces in humans and causes severe diseases. Many clinical strains of K. pneumoniae are highly resistant to...
bla(OXA-181)-positive Klebsiella pneumoniae, Singapore.
TO THE EDITOR: Nordmann et al. (1) raised concern over the global spread of carbapenemase-producing Enterobacteriaceae. In their article, they called attention to the oxacillinase-48 (OXA-48) type car...
Clinical Trials
Selective Digestive Decontamination in Carriers of Carbapenem-Resistant Klebsiella Pneumoniae
There is an urgent need to control our current national outbreak of carbapenem-resistant Klebsiella pneumoniae (CRKP). The purpose of this study is to eradicate CRKP gastrointestinal carri...
Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features
This is a retrospective descriptive study on the clinical and microbiological features of Klebsiella Pneumoniae Necrotizing Fasciitis.
In patients with documented ESBL-producing E.coli and Klebsiella pneumoniae will be allocated to receive colistin or conventional antibiotic regimen.
Risk Factors for Quinolone Resistance Among ESBL Producing Klebsiella Species
This is a retrospective chart review. This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of Klebsiella species. Additionally, the adequ...
Nasopharyngeal Streptococcus Pneumoniae Carriage
Primary Objective: Evaluation of the - Carriage rate of Streptococcus pneumoniae in the nasopharynx of children Secondary Objective: - Carriage rate and distribution of Strepto...
