Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae).
Summary of "Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae)."
In recent years, uses of environment friendly and biodegradable natural insecticides of plant origin have received renewed attention as agents for vector control. During a screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the ethanol extract of Evodia rutaecarpa Hook f. et Thomas (Rutaceae) unripe fruits was found to possess larvicidal activity against the mosquitoes. The aim of this research was to determine larvicidal activity of the ethanol extract of E. rutaecarpa unripe fruits and the isolated constituents against the larvae of the Culicidae mosquito Aedes albopictus. The powder, 5 kg of the fruit material, was extracted with 30 l of 95 % ethanol, filtered, and evaporated to dryness in a rotary vacuum evaporator. The crude extract was then partitioned between methanol-water and n-hexane. The n-hexane fraction was evaporated off to given n-hexane extract. The aqueous layer was repartitioned with chloroform to provide chloroform extract after evaporation of the solvent. Further partitioning with ethyl acetate gave a residue after evaporation of the solvent. Bioactivity-directed chromatographic separation of chloroform extract on repeated silica gel columns led to the isolation of three alkaloids (evodiamine, rutaecarpine, and wuchuyuamide I) and two limonoids (evodol and limonin). The structures of the constituent compounds were elucidated based on high-resolution electron impact mass spectrometry and nuclear magnetic resonance. Evodiamine, rutaecarpine, and wuchuyuamide I exhibited strong larvicidal activity against the early fourth instar larvae of A. albopictus with LC(50) values of 12.51, 17.02, and 26.16 μg/ml, respectively. Limonin and evodol also possessed larvicidal activity against the Asian tiger mosquitoes with LC(50) values of 32.43 and 52.22 μg/ml, respectively, while the ethanol extract had a LC(50) value of 43.21 μg/ml. The results indicated that the ethanol extract of E. rutaecarpa and the five isolated constituents have a good potential as a source for natural larvicides.
Department of Entomology, China Agricultural University, Haidian District, Beijing, 100193, China, firstname.lastname@example.org.
This article was published in the following journal.
Name: Parasitology research
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22526296
- DOI: http://dx.doi.org/10.1007/s00436-012-2923-9
Evodia, a fruit from Evodia rutaecarpa, has been used in oriental medicine, and since its various pharmaceutical actions, including anti-cancer activity, have become known, evodia has been widely used...
The larvicidal effect of hyperforin (1), a bioactive compound of Hypericum perforatum, and deoxycohumulone (2) (biosynthetic precursor of hyperforin) were evaluated against Culex pipiens (Diptera: Cul...
Background & Objectives. The plan of this work was to study the larvicidal activity of Cassia occidentalis (Linn.) against the larvae of Culex quinquefasciatus. These larvae are the most significant v...
Filariasis is a mosquito-borne disease that causes lymphedema and the main vector is Culex quinquefasciatus. A simple measure was taken to eradicate the vector using nanoemulsion. Eucalyptus oil nanoe...
This study investigated the biological activities of five benthic marine algae collected from Northeastern Region of Brazil. The tested activities included larvicidal activity against Aedes aegypti, m...
Isolated minority communities in China use traditional plant-based methods of mosquito control. This study is evaluating 4 plants used in this way by monitoring mosquitoes entering houses...
In metastatic breast cancer (MBC) patients who have already received anthracyclines, taxanes, antimetabolites and vinca-alkaloids and have developed drug resistance to these drugs, therape...
This is a study of the genetics of malaria transmission by the mosquito vector in Africa, Anopheles gambiae. The study focuses on the mosquito vector, not the human subjects infected with...
The combined use of a mosquito repellent and long lasting insecticidal nets (LLINs) by household members would result in a 40% reduction in malaria prevalence compared with households that...
The study will find out how effective rupatadine is in the treatment of mosquito bite symptoms in adult patients allergic to mosquito bites.
Medical and Biotech [MESH] Definitions
A plant genus of the family RUTACEAE. Members contain BERBERINE, indolopyridoquinazoline and other ALKALOIDS and limonoids.
A plant genus of the family RUTACEAE which is used in Chinese medicine (DRUGS, CHINESE HERBAL). Evodiamine and other quinazoline alkaloids (QUINAZOLINES) are obtained from the fruit of E. ruticarpa.
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.
A plant genus of the family MELIACEAE. Members contain meliavolkinin, melianin C and limonoids.