Advertisement

Topics

Antiprotozoal and Antimicrobial Compounds from the Plant Pathogen Septoria pistaciarum.

Summary of "Antiprotozoal and Antimicrobial Compounds from the Plant Pathogen Septoria pistaciarum."

Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids, 17-hydroxy-N-(O-methyl)septoriamycin A (1), 17-acetoxy-N-(O-methyl)septoriamycin A (2), 13-(S)-hydroxy-N-(O-methyl)septoriamycin A (3), and 13-(R)-hydroxy-N-(O-methyl)septoriamycin A (4), together with the known compounds (+)-cercosporin (5), (+)-14-O-acetylcercosporin (6), (+)-di-O-acetylcercosporin (7), lumichrome, and brassicasterol, were isolated from an ethyl acetate extract of a culture medium of Septoria pistaciarum. Methylation of septoriamycin A (8) with diazomethane yielded three di-O-methyl analogues, two of which existed as mixtures of rotamers. We previously reported antimalarial activity of septoriamycin A. This compound also exhibited significant activity against Leishmania donovani promastigotes. Compounds 5-7 showed moderate in vitro activity against L. donovani promastigotes and chloroquine-sensitive (D6) and -resistant (W2) strains of Plasmodium falciparum, whereas compound 5 was fairly active against methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus. Compounds 5-7 also displayed moderate phytotoxic activity against both a dicot (lettuce, Lactuca sativa) and a monocot (bentgrass, Agrostis stolonifera) and cytotoxicity against a panel of cell lines.

Affiliation

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and ⊥Department of Pharmacognosy, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.

Journal Details

This article was published in the following journal.

Name: Journal of natural products
ISSN: 1520-6025
Pages: 883-9

Links

DeepDyve research library

PubMed Articles [6989 Associated PubMed Articles listed on BioPortfolio]

Previous bottlenecks and future solutions to dissecting the Zymoseptoria tritici-wheat host-pathogen interaction.

Zymoseptoria tritici (previously Mycosphaerella graminicola, teleomorph, Septoria tritici, anamorph) causes Septoria tritici blotch, one of the most economically important diseases of wheat (Triticum ...

Plant cysteine-rich peptides that inhibit pathogen growth and control rhizobial differentiation in legume nodules.

Plants must co-exist with both pathogenic and beneficial microbes. Antimicrobial peptides with broad antimicrobial activities represent one of the first lines of defense against pathogens. Many plant ...

Metabolomics of Disease Resistance in Crops.

Plants are continuously exposed to the attack of invasive microorganisms, such as fungi or bacteria, and also viruses. To fight these attackers, plants develop different metabolic and genetic response...

The impact of Septoria tritici Blotch disease on wheat: An EU perspective.

Zymoseptoria tritici is the causal agent of one of the European Union's most devastating foliar diseases of wheat: Septoria tritici Blotch (STB). It is also a notable pathogen of wheat grown in temper...

Bioassay-guided isolation and evaluation of antimicrobial compounds from Ixora megalophylla against some oral pathogens.

Context Ixora megalophylla Chamch. (Rubiaceae) is a new plant species recently found in southern Thailand. Ethyl acetate extracts of its leaves and stems showed antimicrobial activities. Objectives To...

Clinical Trials [375 Associated Clinical Trials listed on BioPortfolio]

Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients

The overall objective of this study is to assess the clinical value of the SeptiFast Test as an adjunct to traditional microbiological, clinical, and other laboratory assessments in early ...

Impact of Rapid Pathogen Identification From Blood Cultures

Septic shock carries high mortality, which may be exacerbated by inappropriate initial therapy. Inappropriate therapy may result from unanticipated antimicrobial resistance. Conversely, po...

The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques

This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheroma...

Lipid-lowering Effect of Plant Stanol Ester Yoghurt Drinks

The aim is to investigate the effects of yoghurt drinks containing two doses of plant stanol ester either with or without added camelina oil on the serum cholesterol levels in moderately h...

Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis

The purpose of this study is to provide patients and their physicians with greater understanding of the risks and benefits of commonly used therapies for treatment of non-CF bronchiectasis

Medical and Biotech [MESH] Definitions

Antiprotozoal and antimicrobial agent used mainly in veterinary practice.

A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant Pathology, 1989, p330)

The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.

Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.

A plant genus of the family LAMIACEAE that contains eudesmane sesquiterpenes and antimicrobial abietane diterpenoids.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topic

Pharmacy
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...


Searches Linking to this Article