Track topics on Twitter Track topics that are important to you
Aim: To evaluate an extended interval dosing (EID) regimen of gentamicin in neonates ≤ 28 weeks gestation. Methods: In 2008, an EID regimen for gentamicin was introduced for all neonates admitted to the NICU in Calgary. The dosing interval was based on a 22 h level after the first dose of 5mg/kg. We conducted an observational study in 33 infants ≤ 28 weeks gestation on the EID regimen from the first day of life and compared gentamicin peak and trough levels with a historical control of 34 infants who received gentamicin in a dose of 2.5 mg/kg every 24 h (TID, traditional interval dosing). Results: In the EID group, based on the 22 h level, dosing interval was 36 hours in 20 and 48 hours in 13 neonates. All neonates, except one, achieved therapeutic peak and trough levels. Compared to the TID group, the EID group had higher peak levels (median 9.8 μg/ml vs. 4.6 μg/ml, p < 0.001) with no difference in trough levels. With target peak levels of 5-12 μg/ml and trough levels of < 2 μg/ml, a higher proportion of neonates in the TID group would need dose adjustment. Conclusion: In neonates ≤ 28 weeks gestation, an EID regimen from day one of life, using a single level 22 h after the first dose for dosing interval, achieves therapeutic peak and trough levels and more optimum peak levels as compared to a TID regimen. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada Department of Pharmacy, Alberta Health Services, Calgary, Alberta, Canada Staff Neonatologist, Victoria General Hospital, Victoria, BC, Canada.
This article was published in the following journal.
Name: Acta paediatrica (Oslo, Norway : 1992)
Published nomograms to monitor extended-interval dosing (EID) gentamicin therapy were based on a fixed dose of 5 or 7 mg/kg. However, the average dose used for EID gentamicin regimen in our setting w...
Nevirapine (NVP) is a key component of antiretroviral prophylaxis and treatment for neonates. We evaluated current WHO weight-band NVP prophylactic dosing recommendations and investigated optimal ther...
Metronidazole dosing recommendations vary significantly for premature infants in pediatric dosing references and can result in confusion for prescribers. We performed a literature search identifying a...
Efficacy of antenatal corticosteroids before 25 weeks of gestation is unclear.
The use of parenteral nutritional supplementation of phosphorus may lead to exhibit higher plasma phosphate concentrations and less radiological features in premature neonates susceptible to osteopeni...
The purpose of this study is to improve the dosing of morphine in critically ill premature neonates.
The purpose of this study is to determine what dosage of gentamicin for use in one-time administration device (Uniject) is appropriate.
Gentamicin, in combination with a beta-lactam antibiotic, is commonly used for treatment of neonatal sepsis. Neonates have a high volume of distribution. It is a paradox that most neonatal...
The most common and widely accepted method of monitoring bilirubin levels in neonates is the use of the laboratory analyzation of serum blood levels. Unfortunately this method is invasive,...
The primary objective of this study is to evaluate the safety and efficacy of lucinactant for inhalation administered as an aerosolized dose in two doses to preterm neonates 26 - 32 weeks ...
A human infant born before 37 weeks of GESTATION.
A human infant born before 28 weeks of GESTATION.
Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.
Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).
Number of fetal deaths with stated or presumed gestation of 20 weeks or more in a given population. Late fetal mortality is death after of 28 weeks or more.
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...