Extended interval dosing of gentamicin in premature neonates ≤ 28 weeks gestation.

06:00 EDT 18th August 2012 | BioPortfolio

Summary of "Extended interval dosing of gentamicin in premature neonates ≤ 28 weeks gestation."

Aim:  To evaluate an extended interval dosing (EID) regimen of gentamicin in neonates ≤ 28 weeks gestation. Methods:  In 2008, an EID regimen for gentamicin was introduced for all neonates admitted to the NICU in Calgary. The dosing interval was based on a 22 h level after the first dose of 5mg/kg. We conducted an observational study in 33 infants ≤ 28 weeks gestation on the EID regimen from the first day of life and compared gentamicin peak and trough levels with a historical control of 34 infants who received gentamicin in a dose of 2.5 mg/kg every 24 h (TID, traditional interval dosing). Results:  In the EID group, based on the 22 h level, dosing interval was 36 hours in 20 and 48 hours in 13 neonates. All neonates, except one, achieved therapeutic peak and trough levels. Compared to the TID group, the EID group had higher peak levels (median 9.8 μg/ml vs. 4.6 μg/ml, p < 0.001) with no difference in trough levels. With target peak levels of 5-12 μg/ml and trough levels of < 2 μg/ml, a higher proportion of neonates in the TID group would need dose adjustment. Conclusion:  In neonates ≤ 28 weeks gestation, an EID regimen from day one of life, using a single level 22 h after the first dose for dosing interval, achieves therapeutic peak and trough levels and more optimum peak levels as compared to a TID regimen. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.


Division of Neonatology, Department of Pediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada Department of Pharmacy, Alberta Health Services, Calgary, Alberta, Canada Staff Neonatologist, Victoria General Hospital, Victoria, BC, Canada.

Journal Details

This article was published in the following journal.

Name: Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227


PubMed Articles [8416 Associated PubMed Articles listed on BioPortfolio]

Gentamicin extended interval regimen and ototoxicity in neonates.

To assess the extended interval regimen gentamicin associated ototoxicity in neonatal intensive care unit using hearing tests.

Feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates.

The objective of our study was to determine the feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates, and to assess response to treatment.

Progressive multifocal leukoencephalopathy associated to natalizumab extended dosing regimen.

A risk for developing progressive multifocal leukoencephalopathy is a major barrier to natalizumab use. Extended dosing intervals have been proposed as a way to maintain therapeutic efficacy and reduc...

Gestational and Postnatal Modulation of Esophageal Sphincter Reflexes in Human Premature Neonates.

Effects of gestational age (GA) and postnatal maturation on upper and lower esophageal sphincter (UES and LES) reflex development remains unclear. We hypothesized very-preterm (VPT) born neonates (< 3...

Outcomes for Extremely Premature Infants.

Premature birth is a significant cause of infant and child morbidity and mortality. In the United States, the premature birth rate, which had steadily increased during the 1990s and early 2000s, has d...

Clinical Trials [3153 Associated Clinical Trials listed on BioPortfolio]

Optimizing the Use of Morphine in Pre-Term Neonates

The purpose of this study is to improve the dosing of morphine in critically ill premature neonates.

Determination of Gentamicin Dosing in Neonatal Patients

The purpose of this study is to determine what dosage of gentamicin for use in one-time administration device (Uniject) is appropriate.

Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)

The aim of the study is to compare the intubation conditions among propofol and remifentanil versus midazolam and remifentanil in premature neonates with respiratory distress syndrome. At ...

Pentoxifylline in the Treatment of NEC in Premature Neonates

Pentoxifylline improves microcirculation and decreases TNF alpha levels associated with sepsis, rendering it of potential therapeutic value in necrotizing enterocolitis in premature neonat...

Buprenorphine Dosing Interval - 5

The purpose of this study is to explore the feasibility of extending the dosing interval of well maintained buprenorphine patients to 48 and 72 hours, leading to eventual 3 times/week dosi...

Medical and Biotech [MESH] Definitions

A human infant born before 37 weeks of GESTATION.

Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.

Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).

Number of fetal deaths with stated or presumed gestation of 20 weeks or more in a given population. Late fetal mortality is death after of 28 weeks or more.

A form of gram-negative meningitis that tends to occur in neonates, in association with anatomical abnormalities (which feature communication between the meninges and cutaneous structures) or as OPPORTUNISTIC INFECTIONS in association with IMMUNOLOGIC DEFICIENCY SYNDROMES. In premature neonates the clinical presentation may be limited to ANOREXIA; VOMITING; lethargy; or respiratory distress. Full-term infants may have as additional features FEVER; SEIZURES; and bulging of the anterior fontanelle. (From Menkes, Textbook of Child Neurology, 5th ed, pp398-400)


Relevant Topics

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Article