Knee biomechanics during walking gait following matrix-induced autologous chondrocyte implantation.

21:55 EDT 26th March 2015 | BioPortfolio

Summary of "Knee biomechanics during walking gait following matrix-induced autologous chondrocyte implantation."

Matrix-induced autologous chondrocyte implantation is a technique for repairing articular cartilage defects in the knee. Despite reported improvements in pain, little is known about the recovery of knee biomechanics during walking gait.
A randomized controlled study design was used to investigate knee biomechanics during gait in 61 patients following matrix-induced autologous chondrocyte implantation, in conjunction with either 'accelerated' or 'traditional' approaches to post-operative weight-bearing rehabilitation. Gait analysis was performed at 3, 6 and 12months post-surgery in both patient groups, and two matched, unaffected control groups for comparison.
The spatiotemporal and ground reaction force parameters were similar between patient groups and their respective control groups at all time points. When compared with controls, both patient groups demonstrated significantly reduced knee extension moments up until, and including, 12months. The traditional group demonstrated a significantly reduced knee adduction moment at 3, 6 and 12months, and a significantly reduced knee flexion moment at 3months. There were no differences in these knee moments between the accelerated patient group and controls.
Overall, a higher level of gait dysfunction was observed in patients who underwent traditional rehabilitation. Future research is needed to investigate the recovery of normal gait following matrix-induced autologous chondrocyte implantation, and its effect on repair tissue development.


School of Sport Science, Exercise and Health, University of Western Australia, Crawley, Perth, Western Australia, 6009.

Journal Details

This article was published in the following journal.

Name: Clinical biomechanics (Bristol, Avon)
ISSN: 1879-1271


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Medical and Biotech [MESH] Definitions

Manner or style of walking.

An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.

Impairment of the ability to coordinate the movements required for normal ambulation (WALKING) which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.

Injuries to the knee or the knee joint.

Replacement for a knee joint.

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