Increased occupational coal dust toxicity in blood of central heating system workers.
Summary of "Increased occupational coal dust toxicity in blood of central heating system workers."
Coal dust causes lung diseases in occupational exposure. Reactive oxygen species have been implicated in the pathogenesis of its toxicity. In this study, serum enzymes, lipid profile and other biochemical values with oxidant/antioxidant status in whole blood and serum of central heating system workers (CHSW; the persons responsible for heating the apartment with coal) were determined to reflect the cell injury. Blood samples were obtained from CHSW (n = 25) and healthy individuals (n = 25). All values were measured in whole blood and serum. ANOVA was used for the estimation of statistical data. In the group of CHSW, creatinine, ferritin, alanin aminotransferase, aspartate aminotransferase, creatine phosphokinase, gamma glutamyl transferase, lactate dehydrogenase and glutathione reductase activities as well as triglyceride, very low density lipoprotein, protein carbonyl and malondialdehide were significantly higher, while transferrin, high density lipoprotein and catalase (CAT) activities were lower than the group of healthy individuals. This result is consistent with hypothesis that respirable coal dust generates lipid and protein oxidation and induces leakage of serum enzymes by cell damage. It also leads to imbalance in antioxidant defense system, lipid profile and other biochemical parameters.
Department of Medical Biology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
This article was published in the following journal.
Name: Toxicology and industrial health
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20724314
- DOI: http://dx.doi.org/10.1177/0748233710381889
ABSTRACT Silicosis and coal worker's pneumoconiosis are serious occupational respiratory diseases associated with the coal mining industry and the inhalation of respirable dusts containing crystalline...
The n-alkanes in PM10 and typical emission sources samples collected during heating and non-heating periods in Taiyuan were determined with GC-MS. Meanwhile, the distribution characteristics and sourc...
To explore genotoxicity in bidi rollers occupationally exposed to bidi tobacco dust.
House dust samples containing 25-738 mg kg-1 Pb from 15 cities in China were assessed for in vitro Pb bioaccessibility and in vivo Pb relative bioavailability. Based on stable Pb isotope ratios, the P...
The purpose of this study is to discover the health status of occupational drivers. The health status includes body mass index (BMI), blood pressure (BP), central obesity, smoking, etc.
Aim : to validate the qualitative analysis by Scanning Electron Microscope (SEM) of lung samples first in induced sputum in correlation to disease second by comparing hazardous particles...
The study is focussed on two main questions: 1. The importance of dampness of the building and home dust as a factor of the subjects= responses. 2. Can measures used in KL...
House dust mite allergy is a common problem, resulting in asthma, chronic swelling of the eyes, and running nose. We test a possibility to immunize subjects sensitized against house dust m...
This study will evaluate the use of the personal computer (PC) in occupational therapy. The results of the study will help occupational therapists develop improved treatment activities usi...
Medical and Biotech [MESH] Definitions
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal miners, but can be seen in urban dwellers and tobacco smokers.
A genus of facultatively anaerobic heterotrophic archaea, in the order THERMOPLASMALES, isolated from self-heating coal refuse piles and acid hot springs. They are thermophilic and can grow both with and without sulfur.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.