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Lipophilic statin use and risk of breast cancer subtypes.

09:10 EDT 26th July 2014 | BioPortfolio

Summary of "Lipophilic statin use and risk of breast cancer subtypes."

Background/Aims: Statins are widely used and of high interest as potential chemopreventive agents for cancer. Preclinical studies suggest that lipophilic statins have anti-cancer properties targeting hormone receptor (HR)-negative breast cancer. Few epidemiologic studies have investigated the relationship between lipophilic statin use and risk of breast cancer, stratified by HR status. We conducted a large case-control study within the Kaiser Permanente of Northern California (KPNC) to determine whether chronic use of lipophilic statins is associated with decreased risk of HR-negative breast cancer, or other breast cancer subtypes.
METHODS:
We identified 22,488 breast cancer cases diagnosed during 1997-2007, and 224,860 controls matched to cases based upon birth year and duration of KPNC pharmacy coverage. Use of lipophilic statins was ascertained using KPNC's comprehensive electronic pharmacy records.
RESULTS:
We found no association between lipophilic statin use (>/=2 years vs. never) and overall breast cancer risk (OR(adj)=1.02; 95%CI=0.97-1.08) in conditional logistic regression models adjusted for oral contraceptive and hormone therapy use. Women who used lipophilic statins did not have a decreased risk of HR-negative breast cancer (OR(adj)=0.98; 95%CI=0.84-1.14), nor altered risk of HR-positive disease (OR(adj)=1.03; 95%CI=0.97-1.10). Furthermore, lipophilic statin use was not associated with risk of any of the intrinsic subtypes, luminal A, luminal B, HER2+/ER- or triple negative.
CONCLUSIONS:
Our results do not support an association of lipophilic statin use with the risk of breast cancer in general or with risks of HR-negative or other breast cancer subtypes specifically. Impact: These findings do not confirm previous reports of a possible preventive association.

Affiliation

1Laboratory of Molecular Pharmacology, National Cancer Institute.

Journal Details

This article was published in the following journal.

Name: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the
ISSN: 1538-7755
Pages:

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