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miRNA in pluripotent stem cells.

06:00 EDT 17th July 2010 | BioPortfolio

Summary of "miRNA in pluripotent stem cells."

Embryonic stem cells and induced pluripotent stem cells are characterized by their ability to self-renew and differentiate into any cell type. The molecular mechanism behind this process is a complex interplay between the transcriptional factors with epigenetic regulators and signaling pathways. miRNAs are an integral part of this regulatory network, with essential roles in pluripotent maintenance, proliferation and differentiation. miRNAs are a class of small noncoding RNAs that target protein-encoding mRNA to inhibit translation and protein synthesis. Discovered close to 20 years ago, miRNAs have rapidly emerged as key regulatory molecules in several critical cellular processes across species. Recent studies have begun to clarify the specific role of miRNA in regulatory circuitries that control self-renewal and pluripotency of both embryonic stem cells and induced pluripotent stem cells. These advances suggest a critical role for miRNAs in the process of reprogramming somatic cells to pluripotent cells.

Affiliation

WM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA; Life Technologies, 5781 Van Allen Way, Carlsbad, CA 92008, USA.

Journal Details

This article was published in the following journal.

Name: Regenerative medicine
ISSN: 1746-076X
Pages: 545-55

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Medical and Biotech [MESH] Definitions

The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.

Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.

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