Track topics on Twitter Track topics that are important to you
Acetaminophen is the most widely used analgesic-antipyretic and is available as an over-the-counter medication in many countries. Although generally safe at usual therapeutic doses, acetaminophen may cause hepatic toxicity in case of chronic or acute overuse and even at therapeutic doses in susceptible individuals. The aim of this article is to review the mechanisms of acetaminophen toxicity and to review the critical steps in the management of acute or chronic acetaminophen intoxication.
Service des urgences, Département de médecine communautaire, de premier recours et des urgences, HUG, 1211 Genève 14. firstname.lastname@example.org
This article was published in the following journal.
Name: Revue mÃ©dicale suisse
Treatment of paracetamol (acetaminophen) overdose with acetylcysteine is standardised, with dose determined only by patient weight. The validity of this approach for massive overdoses has been questio...
Codeine containing analgesics are commonly taken in overdose, but the frequency of respiratory depression is unknown. We investigated whether paracetamol-codeine combination overdoses caused respirato...
Self-prescription of medicines are common especially in low income countries.Paracetamol is a common medicine that is self-prescribed also among university students. Incorrect use of paracetamol can l...
Health systems may play an important role in identification of patients at-risk of opioid medication overdose. However, standard measures for identifying overdose risk in administrative data do not ex...
The antipyretic analgesics, paracetamol, and non-steroidal anti-inflammatory agents NSAIDs are one of the most widely used classes of medications in children. The aim of this review is to determine if...
Investigate the safety and tolerability of PP100-01 add-on treatment to the 12hr NAC treatment regime in patients treated for paracetamol/acetaminophen overdose (POD) when NAC treatment is...
The objective of this study is to investigate whether paracetamol, given at therapeutic doses (2g/day and 3 g/day), may potentiate the anticoagulant effect of warfarin.
The purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic effect.
The aim of this observational study is to compare the use of an extended release paracetamol formulation with standard paracetamol in a cohort of Australian concessional patients with ost...
Paracetamol is one of the most commonly used drugs in the world, indicated for the symptomatic treatment of fever and pain of mild to moderate. More precisely, it is a drug used to relieve...
An accidental or deliberate dose of a medication or street drug that is in excess of what is normally used.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.
A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)
Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.
Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...