Chronic frontal sinus disease: Combined use of platelet-rich plasma and calvarial bone grafts for sinus obliteration in aggressive and secondary cases.

12:57 EDT 29th August 2015 | BioPortfolio

Summary of "Chronic frontal sinus disease: Combined use of platelet-rich plasma and calvarial bone grafts for sinus obliteration in aggressive and secondary cases."

The surgical management of chronic frontal sinusitis can be challenging. The most effective way to treat this condition is sinus obliteration. Several methods have been published. We evaluated the feasibility of a combined treatment, consisting of platelet-rich plasma (PRP) and autologous calvarial bone chips, in chronic frontal sinus diseases (CFSD). PATIENTS AND
From January2001 to June2006, seven patients (four women and three men) were admitted presenting with signs and symptoms of CFSD. Their ages ranged from 35 to 67years. Two patients presented with signs of frontal osteomyelitis and a cutaneous fistula, while endoscopic drainage had failed for five patients. All patients were treated by sinus obliteration though bicoronal access. Free autologous calvarial bone graft combined with PRP was used to repair the frontal sinus.
The frontal sinus repair was successful in all seven patients with progressive resolution of symptoms without perioperative complication. The CT scans at 12 postoperative months showed complete obliteration of sinuses.
Combined PRP and autologous bone graft is a safe and reliable procedure for frontal sinus obliteration. The low rate of complications and the absence of donor site morbidity support using this technique in secondary and particularly complex cases.


Unità Operativa Semplice di Chirurgia Maxillo-Facciale di Pronto Soccorso, AORN "Antonio Cardarelli", Napoli, Italy.

Journal Details

This article was published in the following journal.

Name: Revue de stomatologie et de chirurgie maxillo-faciale
ISSN: 1776-257X


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Medical and Biotech [MESH] Definitions

Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS.

A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.

One of the paired, but seldom symmetrical, air spaces located between the inner and outer compact layers of the FRONTAL BONE in the forehead.

Inflammation of the NASAL MUCOSA in the FRONTAL SINUS. In many cases, it is caused by an infection of the bacteria STREPTOCOCCUS PNEUMONIAE or HAEMOPHILUS INFLUENZAE.

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.


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