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Hypoglycemic effect of a leaf extract of Pseuderanthemum palatiferum (Nees) Radlk in normal and streptozotocin-induced diabetic rats.

08:22 EDT 28th July 2014 | BioPortfolio

Summary of "Hypoglycemic effect of a leaf extract of Pseuderanthemum palatiferum (Nees) Radlk in normal and streptozotocin-induced diabetic rats."

ETHNOPHARMACOLOGICAL
RELEVANCE:
Pseuderanthemum palatiferum (Nees) Radlk (Acanthaceae) was first found in Northern Vietnam and expanded throughout the country including the Mekong Delta region. The leaves of this plant are recommended in folk medicine of Vietnam and Thailand for promoting and treating various diseases including hypertension, diarrhea, arthritis, hemorrhoids, stomach ache, tumors, colitis, bleeding, wounds, constipation, flu, colon cancer, nephritis, and diabetes. AIM OF THE
STUDY:
The hypoglycemic effect of an 80% ethanolic leaf extract from the leaves of Pseuderanthemum palatiferum (PPE) was investigated in normal and streptozotocin (STZ)-induced diabetic rats. MATERIALS AND
METHODS:
The PPE was administered daily and orally to the rats at the doses of 250, 500, and 1000mg/kg body weight (b.w.) for 14 days. The levels of fasting plasma glucose (FPG), serum insulin, and biochemical data such as blood urea nitrogen (BUN), triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and alkaline phosphatase (ALP) were evaluated. The hypoglycemic effect of PPE was compared to that of the known anti-diabetic drug glibenclamide (0.25mg/kg b.w.).
RESULTS:
FPG and serum insulin in normal rats were not significantly different from the control and test groups in all dosages. The treated diabetic rats which had received PPE and glibenclamide showed significantly (p<0.05) decreased FPG and increased serum insulin levels at the end of the experiment. The hypoglycemic effect of PPE at the dose of 250 mg/kg b.w. was significantly (p<0.05) more effective than that of glibenclamide. The serum insulin in PPE fed diabetic rats at the dose of 250mg/kg b.w. was not different from those which had received glibenclamide, and this dose was significantly (p<0.05) more effective than PPE at the doses of 500 and 1000mg/kg b.w. while PPE increased HDL and decreased TC, TG, LDL, BUN and ALP in the diabetic rats.
CONCLUSIONS:
PPE has a beneficial effect in hyperglycemic rats and may prevent the complication of diabetes.

Affiliation

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, 44150 Thailand.

Journal Details

This article was published in the following journal.

Name: Journal of ethnopharmacology
ISSN: 1872-7573
Pages:

Links

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Medical and Biotech [MESH] Definitions

A plant genus of the family MENISPERMACEAE. Members have been used in AYURVEDIC MEDICINE. Hypoglycemic effect has been reported.

A dehydrated extract of thyroid glands. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)

A dehydrated extract of thyroid glands from domesticated animals. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.

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