NMR Study of the Tautomeric Behavior of N-(α-Aminoalkyl)tetrazoles.

06:00 EDT 11th September 2010 | BioPortfolio

Summary of "NMR Study of the Tautomeric Behavior of N-(α-Aminoalkyl)tetrazoles."

N-(α-Aminoalkyl)tetrazoles exist in solution as equilibrium mixtures of N1 and N2 tautomers. The position of equilibrium depends significantly on the polarity of the solvent and the substituents in the tetrazole ring. Interconversion between individual tautomers is shown to proceed via tight ion-pair intermediates in which intramolecular recombination is faster than the intermolecular crossover since the latter probably requires solvent separation of ion-pair intermediates.


Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200.

Journal Details

This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904


DeepDyve research library

PubMed Articles [29311 Associated PubMed Articles listed on BioPortfolio]

A Valence Tautomeric Dinuclear Copper Tetrakisguanidine Complex.

We report on the first valence tautomeric dinuclear copper complex, featuring 2,3,5,6-tetrakis(tetramethylguanidino)pyridine as a bridging redox-active GFA (guanidino-functionalized aromatic) ligand. ...

Synthetic Utilization of α-Aminoalkyl Radicals and Related Species in Visible Light Photoredox Catalysis.

Single electron oxidation of amines provides an efficient way to access synthetically useful α-aminoalkyl radicals as reactive intermediates. After the single electron oxidation of amines, fragmentat...

On the Azine-Hydrazone Tautomerism of Guanylhydrazones: Evidence for the Preference Towards the Azine Tautomer.

Guanylhydrazones have been known for a long time and have wide applications in organic synthesis, medicinal chemistry and material science; however, little attention has been paid towards their electr...

Origin of Substituent Effect on Tautomeric Behavior of 1,2,4-Triazole Derivatives: Combined Spectroscopic and Theoretical Study.

The reaction of 2-aryl-[1,2,4]triazolo[1,5-c]quinazolines with nucleophilic reagents (hydrazine hydrate, sodium hydroxide, sodium methoxide, hydrochloric acid) under acidic conditions leads to formati...

Attendance Behavior of Ex-members in Fitness Clubs: A Retrospective Study Applying the Stages of Change.

The transtheoretical model of behavior change (TTM) is often used to understand and predict health-related behavior. The objective of this study is to apply the TTM's stages of change to examine patte...

Clinical Trials [1325 Associated Clinical Trials listed on BioPortfolio]

Tx for Child Sexual Behavior Problems

A significant minority of children (ages 5-12) display problematic sexual behavior and the persistence of this behavior is oftentimes as stable as other child behavior problems, such as ag...

Self-Injury: Diagnosis and Treatment

Self-injurious behavior is behavior in which a person hurts or harms himself. This behavior sometimes occurs in people with mental retardation or autism. This study will evaluate self-in...

Phase II Study of Stereotypes and Mental Retardation: Neurobiological Basis

OBJECTIVES: I. Determine differences between persons with repetitive behavior disorders and matched controls on measures of motor control relevant to basal ganglia pathophysiology. II. ...

Coronary-Prone Behavior and Cardiovascular Reactivity

To further clarify the concept of coronary-prone behavior and to develop methods of assessing coronary-prone behavior. Specifically, to revise the component scoring system for Potential f...

Double-Blind Naltrexone in Compulsive Sexual Behavior

The goal of the proposed study is to evaluate the efficacy and safety of naltrexone in compulsive sexual behavior. Twenty subjects with DSM-IV compulsive sexual behavior will receive 8 wee...

Medical and Biotech [MESH] Definitions

The discipline pertaining to the study of animal behavior.

The study of animals - their morphology, growth, distribution, classification, and behavior.

The study of the physiological basis of human and animal behavior.

The study of normal and abnormal behavior of children.

Quick Search

DeepDyve research library

Searches Linking to this Article