Track topics on Twitter Track topics that are important to you
Besides typical macroscopical findings in cases of death due to hypothermia (frost erythema, haemorrhagic gastric erosions) there are some histological changes (e.g. lipid accumulation in epithelial cells of renal proximal tubules) which can help to determine the cause of death. In the literature some changes of the pituitary gland are described in case of hypothermia, e.g. haemorrhage and hyperaemia of the anterior lobe of the pituitary gland (adenohypophysis) or a vacuolization of cells in the anterior pituitary. The validity of these morphological changes as hypothermia marker should be proved in our autopsy material. 17 pituitary glands in cases with verified fatal accidental hypothermia were examined histologically and immunohistochemically (HE, Ferric, Azan, LCA, C5b9) and compared with 61 pituitary glands of a matching control group (cases of natural and non-natural death without trauma and long agonal period). Autolytical changes complicated an evaluation but in 5.9% of the study group and 1.6% of the control group a vacuolization of cells could be verified. In none of the examined cases a distinct haemorrhage into the glandular tissue was detected. Histopathological characteristics which are described in the literature as pathogenetic for hypothermia could not be found. Differences concerning histological characteristics of the pituitary glands between cases of fatal hypothermia and the control group were not observed.
Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany.
This article was published in the following journal.
Name: Forensic science international
Death from hypothermia following exhaustion or from various complicated pathologies is no longer a frequent cause of death among combat troops. During a training course under "extreme conditions" in t...
The objective of this research was to evaluate postmortem changes concerning electric charge of human erythrocytes and thrombocytes in fatal accidental hypothermia. The surface charge density values w...
Electromagnetic fields (EMFs) are a class of non-ionizing radiation (NIR) that is emitted from mobile phone. It may have hazardous effects on parotid glands. So, we aimed to investigate the histologic...
Pituitary apoplexy is usually the result of hemorrhagic infarction in a pituitary adenoma. The clinical presentation varies widely and includes asymptomatic cases, classical pituitary apoplexy and eve...
Introduction Gallstone disease is treated commonly with cholecystectomy. Malignant disease of the gallbladder may present similarly and has a poor prognosis. It is common for cholecystectomy specimens...
This is a phase II, open-label, 12-month pilot study in 10 patients with silent corticotroph pituitary tumors testing the hypotheses that Pasireotide LAR treatment of patients with silent ...
This study will evaluate patients with a variety of endocrine disorders in order to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) to...
The purpose of this research project is to ascertain the effectiveness of plastic head covering in prevention of hypothermia. Hypothermia is defined by body temperature
Controlled therapeutic hypothermia is a method of preserving neurological function post-resuscitation.It has been associated with improved functional recovery and reduced histological defi...
The purpose of the study is to determine genetic links among blood-relatives and between spouses of patients with pituitary tumors.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Exocrine glands in animals which secrete scents which either repel or attract other animals, e.g. perianal glands of skunks, anal glands of weasels, musk glands of foxes, ventral glands of wood rats, and dorsal glands of peccaries.
Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
The inspection of one's own body, usually for signs of disease (e.g., BREAST SELF-EXAMINATION, testicular self-examination).
Diabetes Diabetes Endocrine Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several groups of h...
MIRVASO® (BRIMONIDINE) TOPICAL GEL, 0.33%* IS THE FIRST & ONLY FDA-APPROVED TREATMENT DEVELOPED AND INDICATED FOR PERSISTENT FACIAL REDNESS OF ROSACEA Mirvaso® (brimonidine) topical gel, 0.33% is an alpha adrenergic agonist indicated for th...