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07:58 EDT 29th July 2016 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,500,000+

Functional mitral regurgitation in patients with heart failure and depressed ejection fraction.

Functional mitral regurgitation (FMR) is a common complication of left ventricular dysfunction. It is now recognized as an important clinical entity and an independent predictor of poor prognosis in cardiomyopathy patients. In this review, we provide a comprehensive summary of the pathophysiology, latest imaging modalities, and diagnostic criteria for FMR. Additionally, we discuss the recent literature on the continuously evolving surgical and percutaneous treatment options.

Is there a need to assess myocardial viability in patients presenting with heart failure?

Cardiac MRI is unique amongst the cardiac imaging modalities in its ability to directly image myocardial fibrosis using late gadolinium enhancement techniques. The ability to identify not only the presence of fibrosis but also its pattern of distribution within the myocardium can aid in distinguishing between ischemic and nonischemic causes of left ventricular dysfunction, as well as provide valuable prognostic information for patients with various etiologies of heart failure.

Role of multimodality imaging in patients with left ventricular assist device.

The article provides an overview of recent advances in imaging patients with a left ventricular assist device (LVAD).

Sleep: important considerations for the prevention of cardiovascular disease.

Sleep plays many roles in maintenance of cardiovascular health. This review summarizes the literature across several areas of sleep and sleep disorders in relation to cardiometabolic disease risk factors.

Ototoxicity of 12 mg/kg cisplatin in the Fischer 344/NHsd rat using multiple dosing strategies.

Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin's ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The current study examined the difference in ototoxicity of a cumulative 12 mg/kg dose of cisplatin in the Fischer 344/NHsd rat when administered over four different dosing protocols. Hearing sensitivity was mea...

Investigating the effect of emotional intelligence education on baccalaureate nursing students' emotional intelligence scores.

Nursing students, particularly at the time of entering clinical education, experience a great deal of stress and emotion typically related to their educational and clinical competence. Emotional intelligence is known to be one of the required skills to effectively cope with such feelings. The aim of this study was to investigate the effect of training on first-year nursing students' levels of emotional intelligence. This was a quasi-experiment study in which 69 first-year nursing students affiliated with Te...

A Focus on the Epidemiology of Uveitis.

Uveitis is a common, sight-threatening inflammatory ocular disease and includes multiple heterogeneous clinical entities. The prevalence of various types of uveitis depends upon multiple factors, such as age, sex, race, geographic distribution, environmental influence, genetics, and social habits. Epidemiologic research of uveitis is necessary to understand the etiology and immunopathogenesis of this group of diseases. The present study attempts to concentrate on the most recent information on the epidemiol...

The prevalences of and association between nonmedical prescription opioid use and poor sleep among Chinese high school students.

The purpose of this study was to investigate the prevalences of and association between nonmedical prescription opioid use (NMPOU) and sleep quality among Chinese high school students. A cross-sectional study was conducted in Chongqing high school students in 2012, and questionnaires from 18,686 students were completed and eligible for this study. Demographic and NMPOU information was collected using a self-administered questionnaire. The Chinese Pittsburgh Sleep Quality index (CPSQI) was used to assess the...

Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags.

Human hepatocellular carcinoma (HCC) is a severe malignant disease, and accurate and reliable diagnostic markers are still needed. This study was aimed for the discovery of novel marker candidates by quantitative proteomics.

Colorectal Cancer in African Americans: An Update.

This review is an update to the American College of Gastroenterology (ACG) Committee on Minority Affairs and Cultural Diversity's paper on colorectal cancer (CRC) in African Americans published in 2005. Over the past 10 years, the incidence and mortality rates of CRC in the United States has steadily declined. However, reductions have been strikingly much slower among African Americans who continue to have the highest rate of mortality and lowest survival when compared with all other racial groups. The reas...

Do women with smaller breasts perform better in long-distance running?

Literature has established that a range of physiological, biomechanical, and training variables influence marathon performance. The influence of anthropometric characteristics has also received attention. However, despite major marathons exceeding 40,000 participants and approximately a third of these runners being female, no data exist on the influence of the breast on running performance. This cross-sectional study aimed to explore the impact of breast mass on marathon finish time. One hundred and sixty-e...

Eosinophilic esophagitis: current perspectives from diagnosis to management.

Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disease of the esophagus characterized by symptoms related to esophageal dysfunction, as well as significant esophageal eosinophilia. Although dense eosinophilia is the hallmark of EoE, other characteristic histologic features have been described that may help distinguish EoE from other competing diagnoses, although none are specific to EoE. One or more foods and, at times, environmental allergens trigger EoE. Left untreated, esophageal inf...

Negative association of pretreatment cigarette use with smoking-induced striatal dopamine release in smokers receiving bupropion treatment.

In an effort to help identify factors that maintain heavy smoking, this study tested the association of pretreatment cigarette use (cigarettes per day) with striatal dopamine release during smoking-cessation treatment.

NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.

Neural precursor cell-expressed developmentally down-regulated gene 4 (NEDD4) plays an important role in tumor cell growth, yet its role in hepatocellular carcinoma (HCC) remains unclear. This study is to establish NEDD4 as a prognostic biomarker by which the survival of HCC patients can be predicted and to reveal the role of NEDD4 in hepatocellular carcinoma cell growth.

Testicular growth and spermatogenesis: new goals for pubertal hormone replacement in boys with hypogonadotrophic hypogonadism? A multicentre prospective study of hCG/rFSH treatment outcomes during adolescence.

Testosterone treatment for pubertal induction in boys with hypogonadotrophic hypogonadism (HH) provides virilisation, but does not induce testicular growth or fertility. Larger studies evaluating the outcomes of gonadotrophin replacement during adolescence have not been reported to date; whether previous testosterone substitution affects testicular responses is unresolved. We aimed to assess the effects of human chorionic gonadotrophin (hCG) and recombinant FSH (rFSH) in boys and adolescents with HH with re...

Fractionating negative and positive affectivity in handedness: Insights from the Reinforcement Sensitivity Theory of personality.

The Annett Hand Preference Questionnaire (AHPQ), as modified by Briggs and Nebes [(1975). Patterns of hand preference in a student population. Cortex, 11(3), 230-238. doi: 10.1016/s0010-9452(75)80005-0 ], was administered to a sample of 177 participants alongside the Reinforcement Sensitivity Theory of Personality Questionnaire [RST-PQ; Corr, P. J., & Cooper, A. (2016). The Reinforcement Sensitivity Theory of Personality Questionnaire (RST-PQ): Development and validation. Psychological Assessment. doi: 10.1...

Ambulatory diffuse optical tomography and multimodality physiological monitoring system for muscle and exercise applications.

Cervical Osteomyelitis After Pharyngeal Surgical Manipulation.

3-Hydroxy-4-nitrobenzoic Acid as a MALDI Matrix for In-Source Decay.

In-source decay (ISD) in matrix-assisted laser desorption/ionization (MALDI) is a rapid sequencing method for peptides. 1,5-Diaminonaphthalene (1,5-DAN) is a most frequently used matrix for ISD. However, using 1,5-DAN generates mainly c- and z-series ions by N-Cα bond cleavage, which makes it difficult to distinguish leucine (Leu) and isoleucine (Ile), and frequently lacks c(n-1)-series ions owing to proline (Pro) at residues n. Several oxidizing matrices generating a- and x-series ions accompanied by d-se...

Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process.

The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.

Infrared Spectroscopic Investigation of the Acidic CH Bonds in Cationic N-Alkanes: Pentane, Hexane, and Heptane.

Radical cations of n-alkanes (pentane, hexane, and heptane) in the gas phase are investigated by infrared predissociation spectroscopy with the argon or nitrogen tagging. All trans and gauche-involving conformers are identified for these cations by comparisons of observed infrared spectra and vibrational simulations. Intense CH stretch bands are observed in the frequency region lower than the normal alkyl CH stretch frequency. These low frequencies and high intensities of the CH stretch bands are caused by ...

Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients.

This study was to investigate the differences of lymphocyte in the cerebrospinal fluid (CSF) of patients with syphilis meningitis (SM) and tuberculous meningitis (TBM) for new diagnostic insights. Totally, 79 cases of SM and 45 cases of TBM were enrolled. In the CSF, the CD4, CD45RO or CD20 positive lymphocytes were detected by immunohistochemistry. The proportion of CD4 T cells in the CSF lymphocytes in patients with SM was significantly higher than that in patients with TBM (p < 0.05). After medical thera...

U.S. Medical Eligibility Criteria for Contraceptive Use, 2016.

The 2016 U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC) comprises recommendations for the use of specific contraceptive methods by women and men who have certain characteristics or medical conditions. These recommendations for health care providers were updated by CDC after review of the scientific evidence and consultation with national experts who met in Atlanta, Georgia, during August 26-28, 2015. The information in this report updates the 2010 U.S. MEC (CDC. U.S. medical eligibility ...

Risk assessment from exposure to arsenic, antimony and selenium in urban gardens (Madrid, Spain).

This paper discusses the geochemical behaviour of arsenic (As), antimony (Sb) and selenium (Se) in urban gardens and the human health implications associated with urban agriculture. A total of 42 samples from 7 urban gardens in Madrid (Spain) were collected from the top 20 cm of soil. Concentrations of As, Sb and Se and the main soil properties (i.e. total iron, pH, texture, calcium carbonate and organic matter) were determined. A significant correlation was found between arsenic and antimony, and calcium...

Rice root curling, a response to mechanosensing, is modulated by the rice E3-ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (OsHOS1).

Plant development depends on the perception of external cues, such as light, gravity, touch, wind or nutrients, among others. Nevertheless, little is known regarding signal transduction pathways integrating these stimuli. Recently, we have reported the involvement of a rice E3-ubiquitin ligase (OsHOS1, HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1), previously associated with abiotic stress response, in root responses to mechanical stimuli. We showed that OsHOS1 is involved in the regulation of root curli...


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