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11:14 EDT 21st October 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,000,000+

Friday 8th August 1101

The Challenges of Genome-Wide Interaction Studies: Lessons to Learn from the Analysis of HDL Blood Levels.

Genome-wide association studies (GWAS) have revealed 74 single nucleotide polymorphisms (SNPs) associated with high-density lipoprotein cholesterol (HDL) blood levels. This study is, to our knowledge, the first genome-wide interaction study (GWIS) to identify SNP×SNP interactions associated with HDL levels. We performed a GWIS in the Rotterdam Study (RS) cohort I (RS-I) using the GLIDE tool which leverages the massively parallel computing power of Graphics Processing Units (GPUs) to perform linear regressi...

Thursday 7th August 1101

An AGEF-1/Arf GTPase/AP-1 Ensemble Antagonizes LET-23 EGFR Basolateral Localization and Signaling during C. elegans Vulva Induction.

LET-23 Epidermal Growth Factor Receptor (EGFR) signaling specifies the vulval cell fates during C. elegans larval development. LET-23 EGFR localization on the basolateral membrane of the vulval precursor cells (VPCs) is required to engage the LIN-3 EGF-like inductive signal. The LIN-2 Cask/LIN-7 Veli/LIN-10 Mint (LIN-2/7/10) complex binds LET-23 EGFR, is required for its basolateral membrane localization, and therefore, vulva induction. Besides the LIN-2/7/10 complex, the trafficking pathways that regulate ...

Wednesday 6th August 1101

Real-Time UV-Visible Spectroscopy Analysis of Purple Membrane-Polyacrylamide Film Formation Taking into Account Fano Line Shapes and Scattering.

We theoretically and experimentally analyze the formation of thick Purple Membrane (PM) polyacrylamide (PA) films by means of optical spectroscopy by considering the absorption of bacteriorhodopsin and scattering. We have applied semiclassical quantum mechanical techniques for the calculation of absorption spectra by taking into account the Fano effects on the ground state of bacteriorhodopsin. A model of the formation of PM-polyacrylamide films has been proposed based on the growth of polymeric chains arou...

Tuesday 5th August 1101

Correction: Inferring on the Intentions of Others by Hierarchical Bayesian Learning.

[This corrects the article DOI: 10.1371/journal.pcbi.1003810.].

Monday 4th August 1101

Drosophila Tribbles Antagonizes Insulin Signaling-Mediated Growth and Metabolism via Interactions with Akt Kinase.

Drosophila Tribbles (Trbl) is the founding member of the Trib family of kinase-like docking proteins that modulate cell signaling during proliferation, migration and growth. In a wing misexpression screen for Trbl interacting proteins, we identified the Ser/Thr protein kinase Akt1. Given the central role of Akt1 in insulin signaling, we tested the function of Trbl in larval fat body, a tissue where rapid increases in size are exquisitely sensitive to insulin/insulin-like growth factor levels. Consistent wit...

Sunday 3rd August 1101

Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility.

Mycobacterium tuberculosis infection is associated with a spectrum of clinical outcomes, from long-term latent infection to different manifestations of progressive disease. Pro-inflammatory pathways, such as those controlled by IL-1β, have the contrasting potential both to prevent disease by restricting bacterial replication, and to promote disease by inflicting tissue damage. Thus, the ultimate contribution of individual inflammatory pathways to the outcome of M. tuberculosis infection remains ambiguous. ...

Saturday 2nd August 1101

Adaptive Postural Control for Joint Immobilization during Multitask Performance.

Motor abundance is an essential feature of adaptive control. The range of joint combinations enabled by motor abundance provides the body with the necessary freedom to adopt different positions, configurations, and movements that allow for exploratory postural behavior. This study investigated the adaptation of postural control to joint immobilization during multi-task performance. Twelve healthy volunteers (6 males and 6 females; 21-29 yr) without any known neurological deficits, musculoskeletal conditions...

Friday 1st August 1101

Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206.

The AKT signaling pathway has been identified as an important target for cancer therapy. Among small-molecule inhibitors of AKT that have shown tremendous potential in inhibiting cancer, MK-2206 is a highly potent, selective and orally active allosteric inhibitor. Promising preclinical anticancer results have led to entry of MK-2206 into Phase I/II clinical trials. Despite such importance, the exact binding mechanism and the molecular interactions of MK-2206 with human AKT are not available. The current stu...

Thursday 31st July 1101

Co-infections of Malaria and Geohelminthiasis in Two Rural Communities of Nkassomo and Vian in the Mfou Health District, Cameroon.

Human co-infection with malaria and helmimths is ubiquitous throughout Africa. Nevertheless, its public health significance on malaria severity remains poorly understood.

Wednesday 30th July 1101

Molecular Evolutionary and Epidemiological Dynamics of Genotypes 1G and 2B of Rubella Virus.

Rubella Virus (RV), which causes measles-like rashes in children, puts millions of infants at risk of congenital defects across the globe. Employing phylogenetic approaches to the whole genome sequence data and E1 glycoprotein sequence data, the present study reports the substitution rates and dates of emergence of all thirteen previously described rubella genotypes, and gains important insights into the epidemiological dynamics of two geographically widely distributed genotypes 1G and 2B. The overall nucle...

Tuesday 29th July 1101

Chinese Proprietary Herbal Medicine Listed in 'China National Essential Drug List' for Common Cold: A Systematic Literature Review.

Chinese proprietary herbal medicines (CPHMs) have long history in China for the treatment of common cold, and lots of them have been listed in the 'China national essential drug list' by the Chinese Ministry of Health. The aim of this review is to provide a well-round clinical evidence assessment on the potential benefits and harms of CPHMs for common cold based on a systematic literature search to justify their clinical use and recommendation.

Monday 28th July 1101

One Size Fits All? Standardised Provision of Care for Survivors of Sexual Violence in Conflict and Post-Conflict Areas in the Democratic Republic of Congo.

Outcomes of sexual violence care programmes may vary according to the profile of survivors, type of violence suffered, and local context. Analysis of existing sexual violence care services could lead to their better adaptation to the local contexts. We therefore set out to compare the Médecins Sans Frontières sexual violence programmes in the Democratic Republic of Congo (DRC) in a zone of conflict (Masisi, North Kivu) and post-conflict (Niangara, Haut-Uélé).

Sunday 27th July 1101

Anti-Proliferative Activities of Sinigrin on Carcinogen-Induced Hepatotoxicity in Rats.

Liver cancer is one of the leading causes of cancer death worldwide. A very high incidence of new liver cancer cases is diagnosed every year, and metastasis has been found to correlate to poor prognoses in humans. Better treatments for liver cancer are thus clearly needed. Sinigrin is one of the major ingredients present in Brassica nigra, which has been used in combination with other herbs for treatment of various diseases. The anti-proliferative activities of sinigrin were studied in a model of carcinogen...

Saturday 26th July 1101

Evolving Treatments in Multiple Myeloma Patients with Renal Failure.

The introduction of novel agents in multiple myeloma therapy has dramatically improved survivals in latest years. Great progresses have been detected also in particular poor clinical situation such as acute renal failure in which survivals were dismal in the past. Treatment with bortezomib, thalidomide and dialysis associated with high cut-off (HCO)filters can recover more than two thirds of myeloma patients with end stage renal failure. Novel proteasome inhibitors and immunomodulating agents (IMID's) are e...

Friday 25th July 1101

To Conduct Clinical Trial in China, To Go or Not To Go.

In last 10 years, more and more clinical trials have come to China because of potential market/easy access of patient and cost-effectiveness, but looking back, there is less change on the regulatory requirements, and there is a possibility that China government will further strengthen the regulatory requirements for the global pharm/foreign pharm. In 2013, the breaking news is that China government start to investigate the corruption of GSK. So now, shall the global pharm/foreign pharm go to China to conduc...

Thursday 24th July 1101

ESGCT 2014 Abstract Author Index.

Wednesday 23rd July 1101

Guidance of Mesenchymal Stem Cells on Fibronectin Structured Hydrogel Films.

Designing of implant surfaces using a suitable ligand for cell adhesion to stimulate specific biological responses of stem cells will boost the application of regenerative implants. For example, materials that facilitate rapid and guided migration of stem cells would promote tissue regeneration. When seeded on fibronectin (FN) that was homogeneously immmobilized to NCO-sP(EO-stat-PO), which otherwise prevents protein binding and cell adhesion, human mesenchymal stem cells (MSC) revealed a faster migration, ...

Tuesday 22nd July 1101

Neoadjuvant strategies for triple negative breast cancer: 'state-of-the-art' and future perspectives.

Neoadjuvant therapy for triple negative breast cancer (TNBC) has recently generated growing interest given the more aggressive biologic characteristics of such subtype and the lack of approved targeted therapies. Systemic chemotherapy represents the mainstay of treatment for TNBC. Although neoadjuvant chemotherapy has consistently demonstrated higher response rates for TNBC compared to non-TNBC, and the pathological complete response predicts long-term outcome, most patient display residual disease with a h...

Monday 21st July 1101

Different 6-Aryl-Fulvenes exert anti-proliferative effects on Cancer Cells.

Fulvenes represent a class of molecules very interesting under a chemical point of view because are easily accessible starting materials and are still poorly characterized for their biological activities, with the exception of acylfulvene and irofulvenes which have been reported to exert cytotoxic properties. Here, we describe the synthesis and characterization of several aryl-fulvenes together with their effects on cancer cell growth by MTT method. The cytotoxic potential was investigated on a panel of tum...

Sunday 20th July 1101

Susceptibility Testing of the Polymyxins: Where Are We Now?

Antimicrobial susceptibility testing for the polymyxins-colistin and polymyxin B-is fraught with technical challenges. Key among these is the propensity of the polymyxins to adsorb to polystyrene, a material often used for in vitro minimum inhibitory concentration testing devices. This effect may be mitigated by the addition of a surfactant such as polysorbate 80; however, concern exists that polysorbate 80 may act synergistically with the polymyxins and artificially lower minimum inhibitory concentrations....

Saturday 19th July 1101

Comorbidity Effects on Cocaine Dependence Treatment and Examination of Reciprocal Relationships Between Abstinence and Depression.

Objective: We examined comorbid disorders' prevalence, their impact on abstinence, and the impact of depressive symptoms on abstinence and of abstinence on depressive symptoms. Method: A randomized controlled trial's data on outcomes from treating cocaine dependence were used. It compared abstinence-contingent housing and work to contingency management plus behavioral day treatment. Regardless of original trial arm assignment, groups of participants with no additional Axis I disorders (n = 87) and 1 or more...

Friday 18th July 1101

Self-Driven One-Step Oil Removal from Oil Spill on Water via Selective-Wettability Steel Mesh.

Marine oil spills seriously endanger sea ecosystems, coastal environments, and result in a loss of energy resources. Environmental and economic demands emphasize the need for new methods of effectively separating oil-water mixtures, while collecting oil content at the same time. A new surface-tension-driven, gravity-assisted, one-step, oil-water separation method is presented for sustained filtration and simultaneous collection of oil from a floating spill. A bench-top prototype oil collection device uses s...

Thursday 17th July 1101

Efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPSS) in 40 patients with hepatocellular carcinoma.

Portal hypertension and hepatocellular carcinoma (HCC) are major complications of advanced liver cirrhosis. Thus, patients are often affected by both complications. Transjugular intrahepatic portosystemic shunt (TIPSS) is an effective treatment for portal hypertension and its complications. However, no established guidelines for the treatment of symptomatic portal hypertension in HCC patients are currently available. In addition, only limited information exists about the consequence of TIPSS implantation in...

Wednesday 16th July 1101

Organic mixed valency in quadruple hydrogen-bonded triarylamine dimers bearing ureido pyrimidinedione moieties.

Quadruple hydrogen-bonding interactions stabilized the mixed-valence states of dimers of triarylamine derivatives bearing an ureido pyrimidinedione moiety without any electronic coupling. This study represents the first example of proton-coupled "organic" mixed valency in solution with different substituents being used to control the stability.

Tuesday 15th July 1101

Qualitative description of dental hygiene practices within oral health and dental care perspectives of Mexican-American adults and teenagers.

The objectives of this study were to identify dental hygiene themes voiced by adults and teenagers of Mexican origin [or Mexican Americans (MAs)] and place these themes within the larger landscape of oral health and dental care perceptions.


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