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PubMed Journal Database | Fortschritte der Neurologie-Psychiatrie RSS

13:12 EDT 1st July 2016 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 154 from Fortschritte der Neurologie-Psychiatrie

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Pathophysiology and Prognostic Factors of Autoimmune Encephalitis.

More and more forms of autoimmune encephalitis are being identified with the clinical spectrum ranging from epilepsy over movement disorders to psychosis. The increasing appreciation of clinical symptoms raises questions about the underlying pathophysiological mechanisms and prognostic factors. Numerous novel findings on the aetiology demonstrate that diverse tumours, but also infections of the central nervous system such as Herpes encephalitis can trigger autoimmune encephalitis. Antibodies against neurona...

Clinical Phenomenology of Autoimmune Encephalitis.

Antibody-associated disorders of the central nervous system constitute a heterogeneous group of disorders that can be roughly divided into two categories: Classic paraneoplastic syndromes associated with so-called well-characterized antibodies (paraneoplastic neurological disorders, PND) and autoimmune disorders with antibodies to membrane-bound or synaptic antigens (autoimmune encephalitis, AE). The discovery of autoimmune encephalitis has led to a paradigm shift in diagnosis and therapy as well as a recla...

Therapy of Antibody-Associated Autoimmune Encephalitis.

The identification of an antibody-associated autoimmune encephalitis underlying diverse syndromes, typically comprising epileptic seizures and neuropsychiatric symptoms, and their favorable prognosis, when treated with immunotherapies, is one of the success stories in neurology in recent years. Here we review current widely used therapy regimens in antibody-associated autoimmune encephalitis and the prognosis of the different antibody-associated sub-forms. The main therapeutic instruments encompass tumor th...

25 years after re-unification of Germany: An overview on Eastern German psychiatry. Part 2: Pluralistic approaches and the collapse in the 1980s.

This is the second part of a 2-part study of the history of psychiatry in East Germany, i. e. the Soviet Occupied Zone and later German Democratic Republic. This part primarily covers the 1970 s and 1980 s. Starting from the 1970 s, pluralistic views on and approaches to mental illness and its treatment gained ground, which was especially visible in psychotherapy. The exacerbating economic crisis of the 1970 s and 1980 s led to a steadily worsening collapse of the building infrastructure of clin...

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Pharmacotherapy of Anxiety Disorders.

Anxiety disorders belong to the most frequent psychiatric disorders according to epidemiological studies and are associated with a high economic burden. Panic disorder, generalized anxiety disorder, social anxiety disorder, and specific phobia belong to the most important clinical disorders. The etiology is complex, including genetic, neurobiological as well as psychosocial factors. With regard to treatment, both psychotherapy and medication can be employed according to current treatment guidelines. With re...

Vascular parkinsonism.

Parkinsonism may result from cerebral vascular disorders that feature white matter lesions and small vessel pathology. Vascular Parkinsonism typically presents as lower body Parkinsonism with predominant gait impairment. Urinary incontinence and cognitive decline are additional features of the disease. There is a considerable overlap between vascular Parkinsonism and vascular dementia. We review the clinical characteristics of vascular Parkinsonism and discuss the current treatment approaches, as well as th...

Epigenetics in Parkinson's Disease.

The genetic information encoded in the DNA sequence provides a blueprint of the entire organism. The epigenetic modifications, in particular DNA methylation and histone modifications, determine how and when this information is made available and define the specific gene transcription pattern of a given cell. Epigenetic modifications determine the functional differences of genetically identical cells in multicellular organisms and are important factors in various processes from embryonic development to learn...

Dysphagia in Parkinson's Disease: Pathophysiology, Diagnosis and Therapy.

Oropharyngeal and esophageal dysphagia are a frequent, but seldom diagnosed symptom of Parkinson's disease (PD). More than 80 % of patients with PD develop dysphagia during the course of their disease leading to a reduced quality of life, complicated medication intake, malnutrition and aspiration pneumonia, which is a major cause of death in PD. The underlying pathophysiology is poorly understood. Impaired dopaminergic and non-dopaminergic mechanisms of the cortical swallowing network as well as peripher...

Parkinson's Disease at the Border Between Inpatient and Outpatient Care.

Parkinson's disease is characterized by a continuous spectrum of varying severity. The treatment is driven by new and sometimes highly complex therapeutic procedures. These two aspects are responsible for the blurred dividing line between outpatient and inpatient care. The aim of this article is to define criteria that should help determine the indication for inpatient or outpatient treatment. We introduce quality requirements that have already been taken into account in part in therapy modalities such as P...

The Geriatric Patient with Parkinson's Disease - a Neurological Challenge.

Geriatric patients with Parkinson's disease (PD) represent a particular challenge in terms of diagnostics and treatment. This overview article addresses age-related characteristics of this patient group and discusses particularities in PD symptoms in this age group, frequent comorbidities and the resulting polypharmacy. Questions regarding the availability of specialist and therapist care as well as end-of-life aspects are discussed. While comprehensive care structures are not always available, this patient...

Wearable Technique for the Assessment of Parkinson Symptoms: What's the Future?

Parkinson's disease (PD) is a multisystem disorder with a plethora of symptoms affecting the quality of life of patients in the home environment. Due to the rapid development of wearable technique in the health and fitness sector, an increasing number of such wearable devices are available to complement diagnostic strategies of PD symptoms not only in the clinical but also in the home environment. This development has clear advantages over clinical evaluation, as the latter is relatively subjective, time-co...

Perioperative Management of PD Patients.

Both patients and caregivers but also treating physicians are concerned about complications along with surgical interventions. A major problem is abrupt cessation of anti-Parkinson medication, which leads to manifold disturbances, sometimes even to an akinetic crisis. There are several means to guarantee continuous dopaminergic stimulation even in patients that are not allowed to take medication orally before they undergo surgery. Amongst others rectally applied levodopa, amantadine infusions, and especiall...

Cognitive Training in Parkinson's Disease - A New Therapy Option?

Cognitive impairment is a frequent and clinically relevant symptom in patients with Parkinson's disease (PD). Given that pharmacological therapy options are limited, non-pharmacological interventions for the prevention and treatment of cognitive impairment in PD patients are attracting increasing interest. This review summarizes the current state of research regarding cognition-based interventions in PD patients. Eleven randomized controlled studies (RCT) were found in a systematic literature search, all of...

The Right to Choose in Medical Rehabilitation in Germany.

Fear of Heights in Primary School Children.

The life-time prevalence of visual height intolerance in adults is 28 percent, whereas in primary school children, as recently shown, it develops in 34 percent. Triggers and symptoms are similar in children and adults. A significant difference in visual height intolerance of prepubertal children compared to adults is the good prognosis with mostly spontaneous remission within a few years, possibly facilitated by repeated exposure to the triggering situations.

Early Detection of Bipolar Disorders: Current State of the Art and Research Approaches.

Bipolar affective disorders (BD) are severe, recurrent and disabling disorders with devastating consequences for individuals, families and the society. Although this personal burden and costs for the health system provide a compelling rationale for development of early detection and early intervention strategies in BD, the development of at-risk criteria for BD is still in an early stage of research. In this paper we review the literature of clinical data that investigate at-risk criteria. Moreover, we will...

Acute Psychosis after Consumption of Synthetic Cannabinoids.

Introduction: Mocarz is a Legal high that consists of dried parts of plants mixed with synthetic cannabinoids. There is currently limited information on its acute toxicity. Case Report: We describe a 35-year-old patient with no previous medical and psychiatric history who was admitted to the psychiatric clinic after developing agitation and paranoid psychotic symptoms following the use of Mocarz purchased over the internet. Conclusion: Legal highs are a challenge in psychiatric acute care, because they prov...

Substitution therapy with diamorphine.

After a long lead time the substitution with diamorphine was taken into the German catalogue of statutory health insurance in 2010. Currently about 570 patients are treated this way in 9 ambulances in Germany. The study phase as well as the clinical practice are showing the success of this therapy concerning physical and mental health of patients and their circumstances of social life. Thereby substitution with diamorphine is underlying very strict admission criteria regarding patients on the one hand and p...

A New Nomenclature for Functional Disorders is on Demand.

First Aid with Stroke.

Management of acute ischemic stroke.

Man at the Frontier of his Being: Scope of the Concept of "Limit Situation" in Psychiatry and Psychotherapy Following Jaspers' Existential Ontology.

The existential concept of "limit situation" was proposed by Jaspers as the inevitable threshold of human beings at their ordinary mode of being, namely Dasein, which has to be crossed to reach Existence as the proper mode of being after having transcended an existential challenge. A failure at facing limit situations indicates that they are ineluctable and have to be assumed.


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