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PubMed Journal Database | Fortschritte der Neurologie-Psychiatrie RSS

04:21 EDT 23rd August 2017 | BioPortfolio

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Showing PubMed Articles 1–25 of 230 from Fortschritte der Neurologie-Psychiatrie

Practical use of continuous apomorphine infusion via pump.

Parkinson's disease is the second most common neurodegenerative illness after Alzheimer's disease. In its advanced stages, it is characterized by various special symptoms. In addition to non-motor signs, motor complications are most prominent and most often can only be inadequately improved with pulsatile oral therapies. However, with the aid of continuous dopaminergic stimulation, improvements can be achieved even in advanced stages of the disease. This will not only alleviate motor and non-motor symptoms,...

Psychoanalysis and Psychiatrie-Enquete: expert interviews and document analysis.

Background The purpose of this paper is to analyse the perception of the role of psychoanalysis and psychoanalysts in the coming about of the Psychiatrie-Enquete in the Federal Republic of Germany (West Germany). Methods We performed a qualitative content analysis of expert interviews with persons involved in the Enquete (or witnessing the events as mental health professionals active at the time), a selective literature review and an analysis of documents on the Enquete process. Results Expert interviews, r...

Are 10,000 steps per day enough?

Psychotherapy with Adjuvant use of Serotonergic Psychoactive Substances: Possibilities and Challenges.

Background Recently, scientific interest in the therapeutic potential of serotonergic and psilocybin hallucinogens (psychedelics) such as lysergic acid diethylamide (LSD) and entactogens like 3,4-methylendioxymethamphetamine (MDMA) within the framework of psychotherapy has resumed. The present article provides an overview on the current evidence on substance-assisted psychotherapy with these substances. Method A selective search was carried out in the PubMed and Cochrane Library including studies invest...

Trajectory analysis of participation in a sample of stroke patients in German neurological outpatient rehabilitation centres.

Objective We used a trajectory analysis to evaluate the course of participation in a sample of stroke patients in German neurological outpatient rehabilitation centres. Among other benefits, the method of trajectory analysis enables exploration of variables that influence the course of rehabilitation. Method In a multicentric observational study, patients at 17 outpatient neurorehabilitation centres were asked to fill in a questionnaire four times: at the time of admission to the rehabilitation center, on d...

Psychiatric Emergencies in the Preclinical Emergency Medicine Service in Ulm, Germany in 2000 and 2010, and Practical Consequences.

Background Psychiatric emergencies (PE) in preclinical emergency medical services are about 5 - 10 % of all emergencies and represent often a source of difficulties in handling for the non-psychiatric professional helpers that deal with them. Studies informing about quantitative and qualitative changes of PEs in preclinical emergency medicine in Germany are scarce. Methods Therefore, we conducted a retrospective cross-sectional study of PE in a preclinical emergency medical service based on the pr...

Bilateral hippocampal primary CNS lymphoma: unusual differential diagnosis of rapid progressive dementia.

We report on a 63-year old man suffering from rapid progressive dementia due to bilateral hippocampal primary CNS lymphoma. Early diagnosis especially in secondary dementia is essential because of potentially treatable aetiologies with regression of cognitive and behaviour abnormalities. Characteristic imaging findings especially in inflammatory and neoplastic lesions affecting the hippocampal structures are discussed.

Deep brain stimulation in movement disorders: evidence and therapy standards.

The deep brain stimulation (DBS) in movement disorders is well established and in many aspects evidence-based procedure. The treatment indications are very heterogeneous and very specific in their course and therapy. The deep brain stimulation plays very important, but usually not the central role in this conditions. The success in the application of DBS is essentially associated with the correct, appropriate and timely indication of the therapy in the course of these diseases. Thanks to the good standardiz...

Delirium - a frequent neuropsychiatric complication.

Working and mental illness - Do digitalisation and globalisation make us ill?

Therapy of Hemifacial Spasm with Botulinum Toxin.

Hemifacial spasm (HFS) is a frequent disorder characterized by involuntary contractions of those muscles innervated by the facialis nerve on one side of the face. The symptoms can appear as tonic or clonic, intermittent or permanent. Diagnosis is based purely on clinical observation. Differential diagnosis should rely on cranial MRI, which can demonstrate a pathological contact between the nerves and vessels and exclude alternative causation. Often, the symptoms are not marked so that therapy may not be nec...

Rapid Cycling in Bipolar Disorders: Symptoms, Background and Treatment Recommendations.

Rapid cycling bipolar disorder is encountered frequently in clinical practice with a lifetime prevalence of up to 31 %. Besides its association with greater illness severity, increased suicide and comorbidity rates, rapid cycling bipolar disorder has been closely associated with a longer and more complicated course of disease and inadequate treatment response compared to non-rapid cycling bipolar disorder. However rapid cycling does not serve as a stable characteristic of bipolar disorder, though its prev...

Osmotic Demyelination Syndrome due to Severe Hyponatremia Mimicking Hypoxic Encephalopathy.

Hyponatremia and its rapid correction is a well-known cause of osmotic demyelination most commonly affecting the pons. We report on a case of severe hyponatremia likely due to psychogenic polydipsia resulting in hypotonic hyperhydration with resulting cortical laminar necrosis on initial imaging, mimicking hypoxic brain damage. Pontine myelinolysis became apparent on follow-up imaging, illustrating the diagnostic challenges of extrapontine manifestations of severe hyponatremia.

Medicolegal Assessment of Psychic Sequelae after Minor Traumatic Events.

The majority of medicolegal assessments in claimed psychic sequelae after accidents concerns minor traumatic events. In this case, the focus is on three questions: Was the event appropriate to cause a traumatic disturbance according to current psychiatric classification systems (especially current DSM-5)? Which psychical or physical initial injury can be proven beyond reasonable doubt ("full proof") according to German law? What is the impact of personality characteristics and competing life events in the d...

Neuromodulation for the Treatment of Chronic Pain - What is Useful?

Neuromodulatory techniques have replaced the earlier performed neurolesional procedures to treat chronic pain syndromes with only a few exceptions. Nevertheless these procedures are invasive with respective risks and complications and therefore conservative physical, psychological pharmacological as well as interventional treatments should be performed first. Because this therapy is costly, the indication has to be proven carefully with a strict patient selection and also the long-term results have to be co...

Neuromyelitis optica.

Neurological early rehabilitation and pallation.

Update Opipramol.

Opipramol was developed in the 1960s as an antidepressant and has chemical similarities with tricyclic antidepressants. Pharmacodynamic properties with absent reuptake inhibition of serotonin and noradrenaline and agonism at sigma receptors distinguish opipramol from tricyclics. Furthermore, antidepressive effects are smaller than the anxiolytic ones. The mechanism of action of opipramol is currently not sufficiently understood. Agonistic effects at sigma receptors have been linked with therapeutic effects....

Therapeutic Decisions Concerning Severe Neurological Diseases and at the End of Life.

Modern medicine increasingly enables survival of life-threatening diseases. On the other side, however, especially in Neurology, the questions have to be addressed how intensive the initial treatment should be and how to deal with residual states when severe functional or cognitive deficits are expected. In these cases, it is not only important to decide which medical measures are appropriate for the patient, but also whether, given the prognosis, the patient would agree with the suggested measures. This ar...

The Influence of Caseload on Continuous Treatment with Antidementia Drugs.

Objective The goal of this study is to investigate the impact of the number of dementia cases in general and specialist practices on the continuity of treatment with antidementia drugs. Methodology Period between 2004 and 2013: 1116 general practices, 200 specialist practices, 37 178 dementia cases; observation period: 36 months. Practice groups with 1 - 9, 10 - 20, 21-s49, and ≥ 50 dementia cases. Results The treatment continuity is higher in practices with an average of 150 dementia ca...

Alcohol withdrawal and its major complications.

Delirium tremens is one of the most common complications of alcohol withdrawal. It is potentially lethal and therefore should be detected as early as possible and be monitored and treated intensively. The assessment of risk factors with the Luebeck Alcohol-Withdrawal Risk Scale short form (LARS-11) can help to predict the risk of severe withdrawal adequately. As delirium cannot be differentiated from Wernicke-Encephalopathy with sufficient certainty high parenteral doses of Vitamin B1 and Magnesium orally s...

Gait as the Key Symptom: Neurophysiological Analysis supplements Clinical Diagnosis at First Glance.

Symptom Validation in Independent Medical Evaluations.

High prevalence rates of non-authentic complaints identified by experts in the field of insurance medicine draw attention to the risk of services, which are of limited availability and financially compensated, being used in ways that are not goal-oriented. Therefore, symptom validity testing has become a growing issue to prevent non-targeted monetary compensations. This paper outlines the best-evaluated methods and instruments. Based on the data currently available, their validity, in particular in the cont...


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