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14:58 EDT 29th August 2015 | BioPortfolio

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Showing PubMed Articles 1–25 of 108 from Fortschritte der Neurologie-Psychiatrie


Creativity and Mental Disorder.


Somatoform Vertigo Syndromes.

About 30 % of patients presenting to general practitioners complain of episodic or chronic vertigo or dizziness symptoms mostly with substantial impact on their daily living and activities. 30 to 50 % of the dizziness disorders are organically not sufficiently explained and are caused by mental or psychosomatic diseases. Somatoform dizziness syndromes can occur without a preceding vestibular disorder (e. g., primary somatoform dizziness) or they can develop in consequence of an organic vestibular diso...


Acute Pharmacotherapy for Anxiety Symptoms in Patients with Depression.

Patients with depression often also present symptoms of anxiety. First-line pharmacotherapy of comorbid symptoms of depression and anxiety is often a combination therapy of an antidepressant agent, which is combined with benzodiazepines. However, benzodiazepines pose the drawbacks of being associated with cognitive and motor impairments and hold a significant risk for dependence. For some patients, benzodiazepines are contraindicated or patients refuse to take them. Therefore, alternative therapy strategies...


Optimising Pain Therapy for Neurological Inpatients.

Background: The Department of Neurology at the Medical University Graz has implemented a multiprofessional pain management concept and evaluated the outcome by means of a patient survey. Methods: Standard operating procedures for standardised pain measurement, documentation and therapy were developed. All engaged professional participants were trained before implementation. Results: 88.7 % of the surveyed 63 patients reported pain during the hospitalisation. During the night and in the morning, the occurr...


Convergent Validity of SCID-II and TCI: Categorical vs. Dimensional Diagnostics of Personality Disorders Using the Example of Short-Term Prisoners.

In order to objectify the diagnostics of personality disorders, questionnaires and structured interviews are used. Nevertheless, due to different methodological approaches even those instruments arrive at different results very often. Therefore, this study aimed to check the convergent validity of two frequently used instruments - the Structured Clinical Interview for DSM IV Axis II Disorders (SCID-II) and the Temperament and Character Inventory (TCI) - the first one representing the categorical and the lat...


Association between the MAOA-uVNTR Polymorphism and Antisocial Personality Traits in Alcoholic Men.

Aims: We have analysed the MAOA-uVNTR polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. The first aim was to examine the association between the MAOA genotype and the alcoholic phenotype. In the second part of the paper we have analysed the association of the MAOA genotype with impulsive and aggressive behaviour. Genotypes with 3 or 5-repeat alleles (MAOA-L-genotype) were reported to be associated with impulsive and aggressive traits. Methods: The MAOA genotype was de...


Tizanidine Withdrawal Symptoms in Stress Cardiomyopathy.

Introduction: An acute discontinuation of tizanidine, an alpha-2-agonistic muscle relaxant, is associated with reflex tachycardia, hypertension, tremor, hypertonicity and anxiety. Case Report: We describe a 53-year-old patient with broken-heart syndrome, who developed serious tizanidine withdrawal symptoms after high-dosed long-term treatment within the framework of stress cardiomyopathy. Conclusion: Central muscle relaxants like tizanidine might have an impact on the development of delirium. Tizanidine wit...


New Therapeutic Options in Multiple Sclerosis.

Therapeutic options in the treatment of multiple sclerosis (MS) have broadened notably over the past years, especially for relapsing-remitting forms of MS. The revision of the diagnostic criteria simplified and accelerated MS diagnosis, definitions of disease courses were operationalized focussing on disease activity and progression as major determinants. The paradigm of an early treatment initiation is accepted and evidence-based. All these aspects have led to an increasing complexity of therapeutic decisi...

Sunday 16th February 1180

Cerebrospinal Fluid Analysis-Based Diagnosis in Neuroinfections: an Update.

Saturday 15th February 1180

Differential Diagnosis of Bipolar Disorder: Historical and Clinical Implications and Perspectives.

In DSM-5, bipolar disorder (BS) is no longer conceptualised as a pure mood disorder together with unipolar depression, but as a bridge between schizophrenia and depressive disorders. This nosological classification is founded on the historical context of the 19th century. In addition to unipolar depression and schizophrenia, schizoaffective disorder, borderline personality disorder and attention-deficit hyperactivity disorder (ADHD) overlap with BS symptomatology. Overlap also exists with somatic diseases s...

Friday 14th February 1180

Pharmacological Cognitive Enhancement from a Perspective of Misuse and Addiction.

Pharmacological "cognitive enhancement" (CE) and "pharmacological neuroenhancement" (PN) are different terms to describe the use of diverse substances by healthy individuals aiming at an increase of individual cognitive skills. Targets of CE are an increase of vigilance, attention, concentration, memory and motivation. Substances used for pharmacological CE can be divided into two categories: stimulants and non-stimulants. The sub-group of methylxanthines like caffeine as well as the sub-group of amphetamin...

Thursday 13th February 1180

Ketamine - A New Treatment Option for Therapy-Resistant Depression.

The anaesthetic ketamine has been demonstrated to have an antidepressive effect in several randomised controlled studies. Patients with a severe therapy-resistant depression showed response rates of up to 70 % after one single ketamine infusion. In contrast to all other antidepressant treatment options, this effect was already apparent at 24 hours post infusion. However, the antidepressant effect is limited and after two weeks the relapse rate is around 70 %. This review gives a summary of the clinical ...

Wednesday 12th February 1180

The Basel Interview for Psychosis (BIP): Structure, Reliability and Validity.

Background: Although several instruments have been developed to identify patients with an at-risk mental state (ARMS) for psychosis and first episode of psychosis (FEP), up to now there were no instruments for a detailed assessment of risk factors and indicators of emerging psychosis and the temporal development of psychiatric symptoms over the whole life span in these patients. We therefore developed the Basle Interview for Psychosis (BIP). The aim of this study is to describe the development of the BIP an...

Tuesday 11th February 1180

Cerebrospinal Fluid Diagnostics for Neuroinfectious Diseases.

Cerebrospinal fluid analysis is of prime importance to establish an early diagnosis of central nervous system infections. Beside the basic diagnostics containing CSF white cell count, lactate concentration and protein analysis, the targeted search for agents of bacterial, viral or fungal CNS infectious diseases is essential. Decisive methods are bacterial and fungal staining techniques, microbiological culture methods, nucleic acid amplification and antigen detection methods or indirect identification of pa...

Monday 10th February 1180

Hebephilia as a Sexual Disorder.

Background: The term "hebephilia" describes the sexual preference for minors at an early pubertal body age. For most clinicians the definition of hebephilia is not obvious and not integrated as a separate category in the DSM-5. Method: N = 222 self-motivated applicants from the community for the therapy program of the Prevention Project Dunkelfeld in Berlin were assessed concerning their sexual preference towards minors. Results: Approximately two-thirds (n = 153) showed a sexual interest in early p...


The Challenges of Demographic Change - Mental Illnesses Today and Tomorrow.


The Ontario Domestic Assault Risk Assessment (ODARA) - Validity und Authorised German Translation of an Intimate Partner Violence Screening Tool.

On average one third of all women are victimised by intimate partner violence at least once in their life. Many women are affected repeatedly. To efficiently reduce the risk of repeated violence a reliable and valid risk assessment is needed. To date several risk assessment tools have been published in the field of intimate partner violence. There is a strong demand for such tools to be applicable by a wider range of practitioners (e. g., police officers, hospital and victim services' staff) to reliably a...


Stroke Occurence in Germany - On the Comparability of Insurance Data and Registry-Based Data.

Purpose: This article presents epidemiological data regarding stroke frequency in Germany based on nationwide statutory health insurance data (Deutsche BKK) and aims to analyse them in the context of current research. The comparability of the most important resources of stroke frequency data - stroke registers, DRG data and insurance data - is initially discussed in order to assess the presented data adequately. Methods: The study cohort comes from a population of about 1 000 000 people insured with BKK...


The New Payment System in Psychiatry - Do Elderly People Belong to the Losers? An Analysis on the Basis of the VIPP1 Data Base.

The development of the lump-sum reimbursement System in psychiatry and psychosomatics (PEPP) (Klimke et al., 2014) is being negatively considered - also in gerontopsychiatry.Thus it is reasonable to make a timely analysis of the effects of PEPP on health-care structures. For this two analyses have been carried out. On the one hand the day mix index of elderly patients (> 64 years) was compared with that of younger ones (> 17 years,  0.1) but also in outpatient (difference > 0.07) setting. The exact ...


DemTect 40- and DemTect 80+: New Scoring Routines for These Age Groups.

The DemTect, a frequently used cognitive screening tool for the German-speaking population, has been proven to be age-, but not education-dependent. To date, scoring routines for persons under and over 60 years of age have been available. In order to describe the age-effect more specifically, the DemTect was administered to persons under 40 (n = 105; median 33 years [18 - 39]) and over 80 years of age [n = 68; median 83 years [80 - 93}). After transformation of the raw scores, which are base...


Pediatric Bipolar Disorder - Case Report of a Bipolar Patient with Disease Onset in Childhood and Adolescence: Implications for Diagnosis and Therapy.

In recent years, intense controversies have evolved about the existence and exact diagnostic criteria of pediatric bipolar affective disorder. The present study aims to discuss pediatric bipolar affective disorder based on the current literature focussing on the diagnostic prospects. Based on a case study, a process of bipolar disorder developed in childhood is depicted exemplarily. Because of the high comorbidity and overlapping symptoms of paediatric bipolar affective disorder and other psychiatric disord...


Diagnosis of Affective Disorders in DSM-5: Changes and Controversies.



Pushing Back Frontiers in Neurology.


The Significance of Depot Medication in the Long-Term-Treatment of Schizophrenia.

Relapse prevention in schizophrenia is a key aim in therapy. However, it is estimated that approximately 75 % of patients with schizophrenia relapse within five years. Each relapse might worsen the disease and increase the risk of psychosocial and work-related disadvantages. A continuous long-term therapy is able to reduce this risk, but medical non-adherence, which is influenced by numerous factors, is a limitation. Naturalistic studies show that depot-antipsychotics compared with oral antipsychotics lea...