PubMed Journal Database | Fortschritte der Neurologie-Psychiatrie RSS

08:13 EDT 31st October 2014 | BioPortfolio

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Showing PubMed Articles 1–25 of 85 from Fortschritte der Neurologie-Psychiatrie


Pushing Back Frontiers in Neurology.


The Significance of Depot Medication in the Long-Term-Treatment of Schizophrenia.

Relapse prevention in schizophrenia is a key aim in therapy. However, it is estimated that approximately 75 % of patients with schizophrenia relapse within five years. Each relapse might worsen the disease and increase the risk of psychosocial and work-related disadvantages. A continuous long-term therapy is able to reduce this risk, but medical non-adherence, which is influenced by numerous factors, is a limitation. Naturalistic studies show that depot-antipsychotics compared with oral antipsychotics lea...


Optical Coherence Tomography (OCT) - A New Diagnostic Tool in Psychiatry?

Optical coherence tomography (OCT) is a non-invasive, contact-less imaging method which provides an "in vivo" representation of the retina. It allows the quantitative measurement of retinal nerve fibre layer thickness (RNFLT) and macula thickness (MT) and, in addition, is suitable to measure volumes (e. g., macula volume/MV). In the research of neurodegenerative diseases, OCT has been increasingly used and has shown its potential as a possible diagnostic tool over the course of the last few years. In rece...


Stress-Related Risk Factors for Depression in Young Girls.

The prevalence of major depression in adolescents is remarkable. Stress has been hypothesised to contribute to the maintenance of depression in young patients. This study aims to elucidate stress-related predictive variables for the maintenance of depression in young girls. A longitudinal design with a time interval of six months was used to assess stress load and depression in 135 15-year-old girls. Stress was measured by the "Fragebogen zur Erhebung von Stress und Stressbewältigung im Kindes- und Jugenda...


Gender-Specific Differences Relating to Depressiveness in 1st and 2nd Generation Migrants: Results of a Cross-Sectional Study amongst Employees of a University Hospital.

Aims: This study analysed the risk of depression in men and women with a background of immigration by means of a cross-sectional study amongst employees of a German university hospital. In addition we identified gender-specific differences related to risk factors for depressiveness in the subgroups. Methods: 7062 employees with or without a 1st (1G) or 2nd (2G) generation background of migration were questioned with regard to their socio-economic status, to single markers of acculturation, and to existing...


Anti-Stigma Competence for Mental Health Professionals: Results of a Pilot Study of a Further Education Programme for People Working in Psychiatric and Psychosocial Settings.

Background: Mental health professionals are an important target group for anti-stigma interventions, both as subjects to stigmatisation as well as stigmatising actors. Within the framework of the German Research Network on Schizophrenia, a further education training programme on "anti-stigma competence" was developed and evaluated for this target group in a pilot study. Material and Methods: The control-group pilot study included a total of 11 trainings with 123 participants. "Social distance" and "addressi...


Diagnostics and Therapy of "Freezing of Gait" in Patients with Parkinson's Disease.


Delirium and Dementia.


Delirium and Dementia.

Delirium and dementia as organically caused mental disorders exhibit similarities in the clinical and neurological sense and often occur together. The existence of one appears to increase the risk for the development of the other. Although delirium is a very common disorder especially among the elderly, it is often not recognized. For the diagnosis of delirium, an exact family and case history including medication, clinical examination and determination of routine laboratory values are not infrequently nece...


The Relationship between Therapist's Competence and Adherence to Outcome in Cognitive-Behavioural Therapy - Results of a Metaanalysis.

By now psychotherapy research has provided sufficient evidence in favour of the efficacy of psychotherapy, especially of the cognitive behaviour therapy (CBT). Hence one can argue that psychotherapy truly "works". Nevertheless, the rationale for the efficacy and the underlying mechanisms have not yet been explored. Resolving this ambiguity by focusing on the active ingredients in CBT is the aim of our review. More precisely we have explored whether the therapist's competence or his/her adherence to the CBT ...


Electroconvulsive Therapy in Depression: Insights from fMRI, PET and SPECT Studies.

Electroconvulsive therapy (ECT) is the most potent and rapidly acting of all antidepressant treatments in major depressive disorder (MDD). Nuclear and functional magnetic (fMRI) brain imaging studies of ECT have substantially contributed to the neurobiological understanding of this treatment modality. Neuroimaging methods may also validate potential mechanisms of antidepressant action. Models of neural dysfunction in MDD suggest impaired modulation of activity within a cortico-limbic circuitry, along with a...


Quality Assurance in Outpatient Neurological Rehabilitation: Measuring the Effects of Rehabilitation with the Competency Rating Scale.

Background: So far, there are only few studies concerning the outcome of outpatient neurological rehabilitation in Germany. Considering the statutory obligations of quality assurance there is an urgent need of appropriate instruments to assess the rehabilitation outcome. The aim of this study was to assess the appropriateness of the Competency Rating Scale (CRS), which was used to measure rehabilitation outcome, and to collect data of the effects of outpatient neurological rehabilitation as a measure of reh...


New Psychotropic Drugs - "Legal Highs"

Friday 14th August 1051

Clinical neuropsychology: at the crossroads or beyond?

Thursday 13th August 1051

Multiple Sclerosis, Neuromyelitis Optica and Spasticity: Control of Specific Symptoms and Quality of Life.

Spastic movement disorders show a high lifetime prevalence among patients suffering from multiple sclerosis and neuromyelitis optica. Due to the high number of factors interacting with the individual manifestations of spasticity, its symptomatic treatment affords continuous and careful balancing of therapeutic measures. A trend observed over the past few years is to base symptomatic treatment of MS on subjective assessments of functional disorders rather than on specific individual pathological signs and sy...

Wednesday 12th August 1051

Executive Task Performance under Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease Revisited: The Modulating Influence of Apathy, Depression and Mood.

We investigated the moderating influence of apathy, depression and transient mood changes on executive functions under best medical treatment and under postoperative stimulation-on and -off conditions in a sample of 33 patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN), 33 PD patients with pharmacological treatment only and 34 healthy controls. In comparison to clinical and healthy control groups, DBS patients showed worse executive task performance and also...

Tuesday 11th August 1051

Indicators of Patient Care in Psychiatric and Psychosomatic Facilities (VIPP Project) - A Database Project.

Introduction: In Germany a new and unique remuneration system for psychiatric and psychosomatic stationary treatments (PEPP system) was introduced in 2013 on an optional basis. From 2015 it will be mandatory for psychiatric and psychosomatic facilities. The introduction of the PEPP system brings up different questions regarding the possible incentives of the new remuneration system and its effects on the supply of psychiatric and psychosomatic treatments. To conduct these necessary analyses a reliable datab...

Monday 10th August 1051

The "Erlangen System" of Open Care: A Tribute to Gustav Kolb (1870-1938).

Background: This year marks the 80th anniversary of the forced retirement (1st March 1934) of Gustav Kolb (1870 - 1938). He is considered the founder of the "Erlangen System" of open care. The following article pays tribute to Gustav Kolb's "life's work", by delineating the formation, active period and the fall of his "Erlangen system" in its historical context. Method: Relevant archive materials and secondary literature were assessed. Results: Beginning in 1914, Gustav Kolb, as Director of the Mental A...

Sunday 9th August 1051

Mortality and Sudden Unexpected Death in Epilepsy (SUDEP).

Thursday 12th July 1020

What should we eat?

Wednesday 11th July 1020

Glucocorticoids in Neurology: Mechanism of Action, Applications and Side Effects.

Glucocorticoids represent a cornerstone in the therapy for many neurological disorders. Even though their mechanism of action is still not completely understood, synthetic glucocorticoids are given as first line drugs in a number of immunological and non-immunological disorders of the central or peripheral nervous system. For most of these disorders, however, the level of evidence that glucocorticoids are truly effective is still not sufficient. This is why treatment with glucocorticoids cannot be recommend...

Tuesday 10th July 1020

Satellite Systems of the Basal Ganglia - Anatomic Position, Clinical Relevance.

The interaction of basal ganglia and other brain regions is more complex regarding anatomic and functional perspectives than previously assumed. Hence, the classical basal ganglia model has to be extended to at least four satellite systems modulating motor-executive, associative and limbic-motivational brain regions: (i) an indirect projection system, (ii) a striato-nigro-striatal loop, (iii) a "hyperdirect" projection system as well as additional projections to the subthalamic nucleus and (iv) multisynapti...

Monday 9th July 1020

Animal Hoarding: A Mental Disorder with Implications for Public Health.

Animal hoarding (AH) is a mental disorder that is characterised by an excessive number of kept animals, inability to maintain minimal standards of animal care and hygiene, and deficient insight into the thereby developing failures and problems. Although AH as a disease concept is neither represented in the DSM-5 nor the ICD-10, it may be classified as a subform of the hoarding disorder (DSM-5 300.3) that was implemented in the DSM-5 as an obsessive-compulsive disorder. Due to the hygienic deficiencies of t...

Sunday 8th July 1020

Adult ADHD versus Borderline Personality Disorder: Criteria for Differential Diagnosis.

The present study focuses on selected symptom criteria to distinguish between attention deficit/hyperactivity disorder (ADHD) in adults and borderline personality disorder (BPD). A sample of n = 158 subjects was examined, consisting of BPD patients (n = 37), ADHD patients (n = 58), comorbid BPD/ADHD patients (n = 19), a clinical group of patients fulfilling the diagnostic criteria of a depressive disorder (DEP; n = 22) and a non-clinical control group (KG; n = 22). Selected symptom c...

Saturday 7th July 1020

Long-term Treatment of Bipolar Disorder.

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