PubMed Journal Database | Heart rhythm : the official journal of the Heart Rhythm Society 
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Showing PubMed Articles 1–25 of 49 from Heart rhythm : the official journal of the Heart Rhythm Society
EP News: Basic and Translational.
Cardiac resynchronization therapy (CRT) has been proven in clinical trials to be a very effective therapy in appropriate patients. However, although the literature has primarily focused on appropriate implanting techniques and inclusion criteria for CRT devices by electrophysiologists, most patients who receive CRT are managed by their primary care providers with the help of general cardiologists and/or heart failure (HF) specialists. As CRT has been more broadly applied over the past decade, the fragmentat...
Managing atrial fibrillation in the CRT patient: Controversy or consensus?
The cumulative incidence of new onset atrial fibrillation (AF) in patients undergoing cardiac resynchronization therapy (CRT) is substantial, exceeding 25% in multiple recent studies. Although AF patients undergoing CRT show improved echocardiographic parameters, functional status, and quality of life in, they benefit to a lesser degree than do patients in normal sinus rhythm. They also exhibit a trend toward increased mortality. Understanding the barriers to response from CRT among AF patients is critical...
Thinking beyond resynchronization therapy in the failing heart.
The challenge of nonresponders to cardiac resynchronization therapy: Lessons learned from oncology.
Cardiac resynchronization therapy (CRT): Clinical trials, guidelines, and target populations.
Over the last 10 years, several large, well-designed clinical trials have firmly established the role of cardiac resynchronization therapy (CRT) as a recommended treatment strategy for moderate-to-severe heart failure (HF). A review of the relevant results from the MUSTIC, MIRACLE, CONAK-CD, and MIRACLE ICD trials reveals that in patients with New York Heart Association (NYHA) class III-IV HF, CRT produces consistent improvements in quality of life, functional status, and exercise capacity while also provid...
Contemporary and future trends in cardiac resynchronization therapy to enhance response.
The rationale for cardiac resynchronization therapy (CRT), expectations in terms of patient benefit, patient selection for CRT, selection of a CRT pacemaker (CRT-P) vs CRT plus implantable cardioverter-defibrillator (CRT-D) platform, and studies evaluating device programming to enhance benefit from CRT are reviewed. The notion of an "optimal" left ventricular (LV) pacing site, the rationale for identifying and avoiding LV pacing in regions of scar, the use of anatomic, hemodynamic, and electrical parameters...
Advances in electrical therapy for heart failure: Papers from the International ADVANCE CRT Summit.
Editorial for Heart Rhythm: The end is near .... of tinkering that is.
Medical Device Reuse: The Return of Robin Hood?
Fragmented QRS is associated with Torsades de pointes in patients with acquired long QT syndrome.
BACKGROUND: Acquired long QT syndrome (ALQTS) is a disease from secondary repolarization abnormality induced by various predisposing factors. In contrast to congenital LQTS, risk factors that produce ALQTS include organic heart diseases those often exhibit depolarization abnormality. Although various repolarization parameters have been evaluated in ALQTS, there were no reports on existence of depolarization abnormality in association with the occurrence of Torsades de pointes (TdP). OBJECTIVE: We evaluated...
"Proud Flesh" Post Permanent Pacemaker.
Relation Between Renal Function and Response to Cardiac Resynchronization Therapy in MADIT-CRT.
BACKGROUND:: Cardio-renal interactions have been shown to affect outcome in HF patients, but were not related to response to cardiac resynchronization therapy. OBJECTIVE:: We hypothesized that assessment of markers of pre-renal failure may help identify mildly symptomatic heart failure (HF) patients with diminished effective circulating blood volume who will benefit from cardiac resynchronization therapy (CRT). METHODS:: The benefit of CRT with a defibrillator (CRT-D) as compared with defibrillator-only the...
Optical Imaging of the Heart: Seeing Below the Surface.
BACKGROUND:: Cellular replacement strategies using embryonic stem cells (ESCs) and their cardiac derivatives are emerging as novel experimental therapeutic paradigms for treatment of post-myocardial infarction (MI) left ventricular (LV) dysfunction; however, their potential proarrhythmic risk remains unclear. OBJECTIVE:: The purpose of this study was to investigate the functional effect and proarrhythmic risk of ESC transplantation in a mouse model of MI. METHODS:: We compared the functional effects and pro...
BACKGROUND:: Patients with BrS and a spontaneous type-1 ECG are considered to be at greater increased risk for sudden cardiac death than patients with an abnormal ECG only after administration of sodium channel blockers and therefore represent a more severe phenotype. Thus, it could be hypothesized that in the presence of a more severe electrical phenotype, structural and functional changes can be more likely expected since electrical changes can play a causal role in producing structural changes. OBJECTIVE...
The Elusive Atrial Substrate: Complex Fractionated Atrial Electrograms and Beyond.
Most practitioners of AF ablations have attempted to move beyond pulmonary vein isolation, into the realm of physiology-driven ablation for patients with persistent AF. This new strategy involves a combination of a common anatomic approach (with isolation of the pulmonary veins) and an individualized strategy tailored to the electrophysiological characteristics of the atrial substrate present in each patient. In this review, we summarize the current reasoning and controversies related to this new approach....
Differential Heart Rate Dynamics in Transient Left Ventricular Apical and Midventricular Ballooning.
BACKGROUND:: The aim of the present study was to assess potential differences in cardiac autonomic nervous modulation in patients with transient left ventricular apical ballooning syndrome (AB) and the midventricular variant (MB) of this syndrome. OBJECTIVES:: We hypothesized that differences in regional distribution of cardiac autonomic innervation in AB and MB may induce alterations in autonomic modulation and tested this assumption by using a combination of traditional and novel non-linear parameters of...
BACKGROUND:: L-type calcium channel (LTCC) mutations have been associated with Brugada (BrS), Short QT (SQTS) and Timothy (LQT8) syndromes. Little is known about the extent to which mutations LTCC contribute to the J wave syndromes associated with sudden cardiac death. OBJECTIVE:: This study sought to identify mutations in the alpha1, beta2 and alpha2delta subunits of LTCC (Ca(v)1.2) among 205 probands diagnosed with BrS, idiopathic ventricular fibrillation (IVF) and early repolarization syndrome (ERS). CAC...
Linear Ablation of Atrial Fibrillation-What does it do?
BACKGROUND:: Cryoballoon (CB) ablation has emerged as a novel treatment strategy for patients with atrial fibrillation (AF). OBJECTIVE:: The aim of this study was to compare pulmonary vein (PV) isolation (PVI) using CB ablation to RF ablation with regard to myocardial injury, PV reconnection patterns, and outcome. METHODS:: Fifty patients (age of 59+/-9 years, ejection fraction 0.59+/-0.06, left atrial size 41+/-5 mm) with paroxysmal AF were studied. Twenty-five patients underwent PVI using a 28 mm CB. In a...
Can Biological Pacemakers Respond to Physiological Emotional Arousal?
