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Showing "London 2012 Unveils Anti Doping Laboratory" PubMed Articles 1–25 of 14,000+

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East London Experience with Enteric Fever 2007-2012.

The clinical presentation and epidemiology for patients with enteric fever at two hospitals in East London during 2007-2012 is described with the aim to identify preventive opportunities and to reduce the cost of treatment.

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Cobalt chloride doping in racehorses: Concerns over a potentially lethal practice.

Laboratory surveillance of Streptococcus pneumoniae from invasive disease, Chile 2007-2012.

Background: 10-valent pneumococcal vaccine (PCV-10) was introduced in 2011 to the National Immunization Program in Chile. It was administered in 4 doses, but in 2012 it was modified to a 3 dose program. This article shows the results of the Laboratory Surveillance System for Streptococcus pneumoniae isolated of invasive disease from 2007 to 2012 and compares the incidence of invasive pneumococcal disease (IPD) by age groups in the prevaccinal (2007-2010) and postvaccinal period (2012). Methods: Descriptive ...

The quest for assay robustness across the life cycle of a bioanalytical method.

White has been an analytical chemist for 28 years, with a range of knowledge and experience across multiple disciplines including pharmaceuticals, foodstuffs, environmental and forensic analysis. Steve works within the regulated bioanalytical group at GSK supporting both preclinical and clinical bioanalysis. His responsibilities have included leadership of bioanalytical, dose formulation and sample management teams as well as assisting with the set up of the Anti-Doping Testing Laboratory for the London 201...

A call for policy guidance on psychometric testing in doping control in sport.

One of the fundamental challenges in anti-doping is identifying athletes who use, or are at risk of using, prohibited performance enhancing substances. The growing trend to employ a forensic approach to doping control aims to integrate information from social sciences (e.g., psychology of doping) into organised intelligence to protect clean sport. Beyond the foreseeable consequences of a positive identification as a doping user, this task is further complicated by the discrepancy between what constitutes a ...

Report on HbA1c Proficiency Testing in Asia in 2012.

In 2010, the Japan Diabetes Society decided to introduce the National Glycohemoglobin Standardization Program (NGSP) values into clinical practice. Accordingly, NGSP Certification of Japanese manufacturers of HbA1c-related diagnostic reagents and instruments was initiated in February, 2012, through an NGSP network laboratory, the Asian Secondary Reference Laboratory (ASRL) #1. Traceability to the NGSP reference system can be endorsed by manufacturer certification, as well as by the College of American Patho...

The clinical performance of a chemiluminescent immunoassay in detecting anti-cardiolipin and anti-β2 glycoprotein I antibodies. A comparison with a homemade ELISA method.

Abstract Background: Fully automated chemiluminescence immunoassays (CLIAs) are emerging technologies for the detection of anti-cardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies for anti-phospholipid syndrome (APS) classification, which is commonly based on an enzyme-linked immunosorbent assay (ELISA) test result. CLIA and a homemade ELISA were used in this study to detect these antibodies, and their performances were compared. Methods: Sera were collected from 104 patients with primary...

The effect of implicitly incentivized faking on explicit and implicit measures of doping attitude: when athletes want to pretend an even more negative attitude to doping.

The Implicit Association Test (IAT) aims to measure participants' automatic evaluation of an attitude object and is useful especially for the measurement of attitudes related to socially sensitive subjects, e.g. doping in sports. Several studies indicate that IAT scores can be faked on instruction. But fully or semi-instructed research scenarios might not properly reflect what happens in more realistic situations, when participants secretly decide to try faking the test. The present study is the first to in...

Medical laboratory quality systems - a management review.

Purpose - The purpose of this paper is to highlight changes in ISO 15189:2012 and ISO 15189:2007 concerning management review requirements and to present a management review checklist, which includes all the revised ISO 15189's requirements. Design/methodology/approach - The recent revised and updated ISO 15189:2012 standard recommends a management review using a process approach and includes some additional topics. Findings - The management review is a key element in many quality management systems, includ...

Unlocking the functional properties in one-dimensional MoSI cluster polymers by doping and photo-induced charge transfer.

To improve functionalization of MoSI cluster polymers we have studied the effects of adsorption doping on the electrical transport, bundling, and optical absorption spectra. Doping results both in enhanced conductivity and aggregated bundles in dispersion. The different electronic properties of different bundle diameters can be ascribed to self-doping during the synthesis. Furthermore, doping shifts the characteristic absorption peaks and transfers oscillator strength to lower energies. Femtosecond optical ...

Stability of the Zhang-Rice Singlet with Doping in Lanthanum Strontium Copper Oxide Across the Superconducting Dome and Above.

The spin character of the states at the top of the valence band in doped La_{2-x}Sr_{x}CuO_{4} (x=0.03, 0.07, 0.15, 0.22, and 0.30) has been investigated using spin-polarized resonant photoemission. A clear Zhang-Rice singlet (ZRS) is observed at all doping levels. Its stability and polarization are preserved as a function of doping, suggesting that the concept of the ZRS can be used across a wide doping range and up to the metallic nonsuperconducting overdoped regime. The results are significant for theore...

Anti-oxidant, anti-inflammatory and antinociceptive properties of the acetone leaf extract of vernonia amygdalina in some laboratory animals.

Vernonia amygdalina is a medicinal plant of great importance that has its fresh leaves rich in vitamins and salt hence, it is valuable in human diet. The anti-oxidant, anti-inflammatory and analgesic activities of its acetone leaf extract were evaluated in this study to validate its folkloric use.

Tunable Dirac electron and hole self-doping of topological insulators induced by stacking defects.

Self-doping of Dirac cones in Bi2X3 (X=Se, Te) topological insulators can be tuned by controlling the sequence of stacking defects in the crystal. Twin boundaries inside Bi2X3 drive n- or p-type doping of the surface states, originated by the defect induced spontaneous polarization. Doping up to 10(12)-10(13) e/cm(2) may be achieved depending on the defect distribution. Our findings open the route to fabrication of Bi2X3 surfaces with tailored intrinsic charge and spin densities.

Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.

The Willingham et al., 2012, published in PNAS in 2012. The key experiments being replicated are those reported in Figure 6A-C and Table S4. In these experiments, Willingham et al., 2012 test the safety and efficacy of anti-CD47 antibody treatment in immune competent mice utilizing a syngeneic model of mammary tumor growth in FVB mice. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.

Controlling the dopant dose in silicon by mixed monolayer doping.

Molecular monolayer doping (MLD) presents an alternative to achieve doping of silicon in a nondestructive way, and holds potential for realizing ultra-shallow junctions and doping of non-planar surfaces. Here, we report the mixing of dopant-containing alkenes with alkenes that lack this functionality, at various ratios to control the dopant concentration in the resulting monolayer and concomitantly the doping dose in the silicon substrate. The mixed monolayers were grafted onto hydrogen-terminated silicon u...

Wide-Range Controllable n-Doping of Molybdenum Disulfide (MoS2) through Thermal and Optical Activation.

Despite growing interest in doping two-dimensional (2D) transition metal dichalcogenides (TMDs) for future layered semiconductor devices, controllability is currently limited to only heavy doping (degenerate regime). This causes 2D materials to act as metallic layers, and an ion implantation technique with precise doping controllability is not available for these materials (e.g., MoS2, MoSe2, WS2, WSe2, graphene). Since adjustment of the electrical and optical properties of 2D materials is possible within a...

Functionalization of Transition Metal Dichalcogenides with Metallic Nanoparticles: Implications for Doping and Gas-Sensing.

Transition Metal Dichalcogenides (TMDs), belonging to the class of two-dimensional (2D) layered materials, have instigated a lot of interest in diverse application fields due to their unique electrical, mechanical, magnetic and optical properties. Tuning the electrical properties of TMDs through charge transfer or doping is necessary for various optoelectronic applications. This paper presents the experimental investigation of the doping effect on TMDs, mainly focusing on molybdenum disulphide (MoS2), by me...

Dramatic decline in substance use by HIV-infected pregnant women in the United States from 1990 to 2012.

We aimed to describe temporal changes in substance use among HIV-infected pregnant women in the United States from 1990 to 2012.

Insights into N-doping in single-walled carbon nanotubes for enhanced activation of superoxides: a mechanistic study.

Emerging characteristics upon nitrogen-doping were differentiated in the activation of superoxides over single-walled carbon nanotubes. Both experimental and theoretical studies revealed that enhanced peroxymonosulfate (PMS) activation is ascribed to a nonradical process while persulfate (PS) activation is accelerated via directly oxidizing water, yet hydrogen peroxide (H2O2) activation is inert to N-doping. This study details the first insights into versatile N-doping in carbocatalysis for organic oxidatio...

The effect of inter-laboratory variability on the protein:creatinine (UPC) ratio in canine urine.

Quantification of proteinuria is a fundamental step in staging dogs with chronic kidney disease and in monitoring the course of disease or the efficacy of anti-proteinuric treatments. Analytical precision and accuracy of the proteinuria assessment could be affected by several factors such as biological variability, different operators and quality control materials. The aim of this study was to assess whether inter-laboratory variability could affect the urinary protein to creatinine (UPC) ratio and whether ...

Anti-inflammatory effects of adenosine N1-oxide.

Adenosine is a potent endogenous anti-inflammatory and immunoregulatory molecule. Despite its promise, adenosine's extremely short half-life in blood limits its clinical application. Here, we examined adenosine N1-oxide (ANO), which is found in royal jelly. ANO is an oxidized product of adenosine at the N1 position of the adenine base moiety. We found that it is refractory to adenosine deaminase-mediated conversion to inosine. We further examined the anti-inflammatory activities of ANO in vitro and in vivo.

Decoupling the Lattice Distortion and Charge Doping Effects on the Phase Transition Behavior of VO2 by Titanium (Ti(4+)) Doping.

The mechanism for regulating the critical temperature (TC) of metal-insulator transition (MIT) in ions-doped VO2 systems is still a matter of debate, in particular, the unclear roles of lattice distortion and charge doping effects. To rule out the charge doping effect on the regulation of TC, we investigated Ti(4+)-doped VO2 (TixV1-xO2) system. It was observed that the TC of TixV1-xO2 samples first slightly decreased and then increased with increasing Ti concentration. X-ray absorption fine structure (XAFS)...

Laboratory methods to detect antiphospholipid antibodies.

This chapter reviews several important themes pertaining to the antiphospholipid syndrome (APS), including a description of the clinical features, a discussion of the main autoantigen, beta 2-glycoprotein I (β2GPI), and insights into the characteristics of the pathogenic anti-β2GPI autoantibodies. Evidence-based considerations for when to test for APS are explored, along with the clinical significance of patients testing positive on multiple APS assays, so-called triple positivity. A detailed review of re...

Laboratory-acquired lethal infections by potential bioweapons pathogens including Ebola in 2014.

Researchers studying both cellular and viral disease agents in the laboratory have become infected since the early days of microbiology 150 years ago. However, in the early 21st century, new concerns about bioweapons being used to generate terror and also with a series of newly emerging or newly understood disease-causing microbes have resulted in infections and deaths of workers studying these microbes in the laboratory, generally to gain understanding and to develop treatments and vaccines. Here, five exa...

Enhancement of anti-tumor effect of particulate vaccine delivery system by 'bacteriomimetic' CpG functionalization of poly-lactic-co-glycolic acid nanoparticles.

Low immunogenicity remains a major obstacle in realizing the full potential of cancer vaccines. In this study, we evaluated CpG-coated tumor antigen (Tag)-encapsulating 'bacteriomimetic' nanoparticles (CpG-nanoparticle [NP]-Tag NPs) as an approach to enhance anti-tumor immunity.



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