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05:11 EDT 23rd July 2016 | BioPortfolio

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Showing "London 2012 Unveils Anti Doping Laboratory" PubMed Articles 1–25 of 13,000+

Questions of fairness and anti-doping in US cycling: The contrasting experiences of professionals and amateurs.

The focus of researchers, media and policy on doping in cycling is often limited to the professional level of the sport. However, anti-doping test results since 2001 demonstrate that banned substances are also used by US cyclists at lower levels of the sport, necessitating a broader view of the patterns and motivations of substance use within the sport. In this article, we describe and explain the doping culture that has emerged in domestic US cycling among amateur and semi-professionals. Through analysis o...

Methods for Doping Detection.

Over the past few years, the World Anti-Doping Agency (WADA) has focused its efforts on detecting not only small prohibited molecules, but also larger endogenous molecules such as hormones, in the view of implementing an endocrinological module in the Athlete Biological Passport (ABP). In this chapter, the detection of two major types of hormones used for doping, growth hormone (GH) and endogenous anabolic androgenic steroids (EAASs), will be discussed: a brief historical background followed by a descriptio...

Analytical strategies for doping control purposes: needs, challenges and perspectives.

The fight against doping in sports has been governed since 1999 by the World Anti-Doping Agency (WADA), an independent institution behind the implementation of the World Anti-Doping Code (Code). The intent of the Code is to protect clean athletes through the harmonization of anti-doping programs at the international level with special attention to detection, deterrence and prevention of doping.1 A new version of the Code came into force on January 1st 2015, introducing, among other improvements, longer peri...

Seizures of doping substances at the Swiss Border - a descriptive investigation.

This retrospective study evaluates the content, the destination and the source of 960 postal items seized by the Swiss customs authorities at the Swiss border between 2013 and 2014. The packages were seized because they contained at least one prohibited doping product as identified by the Swiss law on encouraging sports and physical activity. A total number of 1825 different doping products were confiscated from these parcels, accounting for an average of 1.9 doping products per seized item. In 74% of the c...

Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes.

Salbutamol abuse detection by athletes is based on a urinary upper threshold defined by the World Anti-Doping Agency (WADA). However, this threshold was determined in healthy, untrained individuals and after a dose of salbutamol inhaled that might not really mirror the condition of asthmatic athletes and the experts's guidelines for asthma management. We aimed to revise this threshold in accordance with recommended clinical practice (that appear to be different from the actual WADA recommendation) and in ex...

Photodegradation of ibuprofen by TiO2 co-doping with urea and functionalized CNT irradiated with visible light - Effect of doping content and pH.

Ibuprofen (IBP) is one kind of non-steroidal anti-inflammatory drugs (NSAIDs), which are classified as Pharmaceuticals and Personal Care Products (PPCPs). IBP possesses bioactive property and the substantial use of IBP results in a harmful impact on bioreceptors even in small concentrations. Accordingly, the treatment of these wastewaters is important before discharging them into the ecosystem. The photodegradation of IBP with TiO2 co-doped with functionalized CNTs (CNT-COOH and CNT-COCl) and urea, named as...

Doping silicon nanocrystals and quantum dots.

The ability to incorporate a dopant element into silicon nanocrystals (NC) and quantum dots (QD) is one of the key technical challenges for the use of these materials in a number of optoelectronic applications. Unlike doping of traditional bulk semiconductor materials, the location of the doping element can be either within the crystal lattice (c-doping), on the surface (s-doping) or within the surrounding matrix (m-doping). A review of the various synthetic strategies for doping silicon NCs and QDs is pres...

Programmed Death Ligand 1 Immunohistochemistry: Friend or Foe?

The approval of anti-PD-1 therapies for non-small cell lung cancer has directed the spotlight on PD-L1 immunohistochemistry as the latest predictive biomarker potentially required in this disease. Several other drugs in this class will likely be approved in the future and each has been developed with a unique anti-PD-L1 immunohistochemistry test. The prospect of 5 drugs competing in the same treatment area, each possibly requiring PD-L1 immunohistochemistry testing, presents a challenge for pathologists unl...

Level of Viral Suppression and the Cascade of HIV Care in a South-African Semi-urban Setting in 2012.

In 2012, seven years after the introduction of ART in the South-African township of Orange Farm, we measured the proportion of HIV-positive people who were virally suppressed, especially among high risk groups (women 18-29y and men 25-34y).

Performance Assessment of Internal Quality Control (IQC) Products in Blood Transfusion Compatibility Testing in China.

Internal quality control (IQC) is a critical component of laboratory quality management, and IQC products can determine the reliability of testing results. In China, given the fact that most blood transfusion compatibility laboratories do not employ IQC products or do so minimally, there is a lack of uniform and standardized IQC methods. To explore the reliability of IQC products and methods, we studied 697 results from IQC samples in our laboratory from 2012 to 2014. The results showed that the sensitivity...

Spotlight on Athletes With a Disability: Malaysian Newspaper Coverage of the 2012 London Paralympic Games.

This study analyzed newspaper coverage of the 2012 London Paralympic Games by 8 Malaysian newspapers. Articles and photographs from 4 English-language and 4 Malay-language newspapers were examined from August 28 (1 day before the Games) to September 10, 2012 (1 day after the Games closing). Tables, graphs, letters, fact boxes, and lists of events were excluded from analysis. A total of 132 articles and 131 photographs were analyzed. Content analysis of the newspaper articles revealed that most (62.8%) of th...

Surface Charge Transfer Doping of Monolayer Phosphorene via Molecular Adsorption.

Monolayer phosphorene has attracted much attention owing to its extraordinary electronic, optical, and structural properties. Rationally tuning the electrical transport characteristics of monolayer phosphorene is essential to its applications in electronic and optoelectronic devices. Herein, we study the electronic transport behaviors of monolayer phosphorene with surface charge transfer doping of electrophilic molecules, including 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodime- thane (F4TCNQ), NO2, and Mo...

Cell scientist to watch - Julie Welburn.

Julie Welburn pursued her PhD degree at the Laboratory of Molecular Biophysics, University of Oxford, under the guidance of Jane Endicott and Martin Noble. Following a short postdoc in the laboratory of Eva Nogales at University of California Berkeley, she then moved to the Whitehead Institute for Biological Research at MIT, USA in 2008 to study mitosis in Iain Cheeseman's laboratory. Since 2012, Julie has been running her own group at the Wellcome Trust Centre for Cell Biology in Edinburgh as a Cancer Rese...

Laser-Assisted Doping: Site Selective Doping of Ultrathin Metal Dichalcogenides by Laser-Assisted Reaction (Adv. Mater. 2/2016).

Laser-assisted phosphorus doping is demonstrated by J. Wu, C. P. Grigoropoulos, and co-workers on page 341, on ultrathin transition-metal dichalcogenides (TMDCs), including n-type MoS2 and p-type WSe2 . Temporal and spatial control of the doping is achieved by varying the laser irradiation power and time, demonstrating wide tunability and high site selectivity with high stability. The laser-assisted doping method may enable a new avenue for functionalizing TMDCs for customized nanodevice applications.


Total hemoglobin (Hb) mass is an important determinant of aerobic power. The glycoprotein erythropoietin (Epo) promotes the production of red blood cells (RBCs). The present article reviews the regulation of erythropoiesis and ways of its manipulation. The various Epos, e.g. recombinant human (rh)Epo and (epoetin), and their long-acting analogues can be misused by cheating athletes, but the drugs are detectable by chemical tests, because their glycan isoform structures differ from those of endogenous Epo. S...

Pressure-Induced Charge Transfer Doping of Monolayer Graphene/MoS2 Heterostructure.

A unique way of achieving controllable, pressure-induced charge transfer doping in the graphene/MoS2 heterostructure is proposed. The charge transfer causes an upward shift in the Dirac point with respect to Fermi level at a rate of 15.7 meV GPa(-1) as a function of applied hydrostatic pressure, leading to heavy p-type doping in graphene. The doping was confirmed by I2D /IG measurements.

Doping-Induced Tunable Wettability and Adhesion of Graphene.

We report that substrate doping-induced charge carrier density modulation leads to the tunable wettability and adhesion of graphene. Graphene's water contact angle changes by as much as 13˚ as a result of a 300-meV change in doping level. Upon either n- or p-type doping with subsurface polyelectrolytes, graphene exhibits increased hydrophilicity. Adhesion force measurements using a hydrophobic self-assembled monolayer-coated atomic force microscopy probe reveal enhanced attraction toward undoped graphene, ...

Outer retinal tubulation in diabetic macular edema following anti-VEGF treatment.

To address the presence and features of outer retinal tubulation (ORT) found in diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) and to differentiate between ORT and cystoid DME, which have different plans of management.

BVA at the new look London Vet Show.

This year's London Vet Show is taking place at ExCel London on November 17 and 18. Tim Keen, BVA marketing manager, looks at what members can expect.

Are ESPGHAN "Biopsy-Sparing" Guidelines for Celiac Disease also Suitable for Asymptomatic Patients?

In 2012, European Society of Pediatric Gastroenterology, Hepatology, and Nutrition published novel guidelines on celiac disease (CD) diagnosis. Symptomatic children with serum anti-transglutaminase (anti-tTG) antibody levels ≥10 times upper limit of normal (ULN) could avoid duodenal biopsies after positive HLA test and serum anti-endomysial antibodies (EMAs). So far, both asymptomatic and symptomatic patients with anti-tTG titer

Gate-Tunable Dirac Point of Molecular Doped Graphene.

Control of the type and density of charge carriers in graphene is essential for its implementation into various practical applications. Here, we demonstrate the gate-tunable doping effect of adsorbed piperidine on graphene. By gradually increasing the amount of adsorbed piperidine, the graphene doping level can be varied from p- to n-type, with the formation of p-n junctions for intermediate coverages. Moreover, the doping effect of the piperidine can be further tuned by the application of large negative ba...

Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations.

The issue of illicit performance enhancement spans human and animal sport in presumably equal measure, with prohibited substances and methods of doping conveying both ways. Due to the proven capability of unbound ionic cobalt (Co(2) (+) ) to stimulate erythropoiesis in humans, both human and equine anti-doping regulations have listed cobalt as a banned substance, and in particular in horse drug testing, thresholds for cobalt concentrations applying to plasma and urine have been suggested or established. Rec...

Global Measles and Rubella Laboratory Network Support for Elimination Goals, 2010-2015.

In 2012, the World Health Assembly endorsed the Global Vaccine Action Plan (GVAP)* with the objective to eliminate measles and rubella in five World Health Organization (WHO) regions by 2020. In September 2013, countries in all six WHO regions had established measles elimination goals, and additional goals for elimination of rubella and congenital rubella syndrome were established in three regions (1). Capacity for surveillance, including laboratory confirmation, is fundamental to monitoring and verifying e...

Analysis of sulfate metabolites of the doping agents oxandrolone and danazol using high performance liquid chromatography coupled to tandem mass spectrometry.

The direct detection of sulfate conjugates of anabolic androgenic steroids (AAS) can be a powerful tool in doping control analysis. By skipping the solvolysis step analysis time can be reduced, and due to long term sulfate metabolites the detection time can be significantly extended as demonstrated for some AAS. This study presents the successful identification of sulfate metabolites of the doping agents oxandrolone and danazol in excretion urines by high performance liquid chromatography coupled to tandem ...

Hepatitis E Virus in 3 Types of Laboratory Animals, China, 2012-2015.

We found seroprevalences for hepatitis E virus (HEV) of 7.5%, 18.5%, and 83.3% in specific pathogen-free (SPF) laboratory rabbits, monkeys, and pigs, respectively, in China. HEV RNA was detected in 4.8% of SPF rabbits, and 11 rabbits had latent infections. Screening for HEV in SPF animals before relevant experiments are conducted is recommended.

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