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PubMed Journals Articles About "London 2012 Unveils Anti Doping Laboratory" RSS

22:45 EDT 24th April 2017 | BioPortfolio

London 2012 Unveils Anti Doping Laboratory PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest London 2012 Unveils Anti Doping Laboratory articles that have been published worldwide.

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Showing "London 2012 Unveils Anti Doping Laboratory" PubMed Articles 1–25 of 13,000+

CHALLENGES IN DETECTING SUBSTANCES FOR EQUINE ANTI-DOPING.

The artificial increase of the physical capability of horses using drugs is well-known in racing and in other equine sports. Both illicit and therapeutic substances are regarded as prohibited substances in competition in most countries. Some countries do make distinctions for a few, specific drugs which are, however, allowed for use in other countries. The primary objective in the case of doping control is the detection of any trace of drug exposure, either parent drug or any of its metabolites, using the m...


Cohort profile: Examining Neighbourhood Activities in Built Living Environments in London: the ENABLE London-Olympic Park cohort.

The Examining Neighbourhood Activities in Built Living Environments in London (ENABLE London) project is a natural experiment which aims to establish whether physical activity and other health behaviours show sustained changes among individuals and families relocating to East Village (formerly the London 2012 Olympics Athletes' Village), when compared with a control population living outside East Village throughout.

Potential detection of low-dose transdermal testosterone administration in blood, urine and saliva.

Administration of low amounts of endogenous hormones - so called micro-dosages - are supposed to represent a major challenge in doping analysis. To model such a situation, we have studied transdermal administrations of 2.4 mg/24 h testosterone patches and examined various steroid concentrations in blood, urine and saliva of 11 volunteers. Multiple samples were collected at t = 0, 3, 6, 9, 24, 48 and 72 h in four different phases, i.e. all combinations with/without physical exercise and with/withou...


A review of designer anabolic steroids in equine sports.

In recent years the potential for anabolic steroid abuse in equine sports has increased due to the growing availability of "designer steroids". These compounds are readily accessible online in "dietary" or "nutritional" supplements and contain steroidal compounds which have never been tested or approved as veterinary agents. They typically have unusual structures or substitution and as a result may pass undetected through current anti-doping screening protocols, making them a significant concern for the int...

Discordant genotyping results using DNA isolated from anti-doping control urine samples.

The UGT2B17 gene deletion polymorphism is known to correlate to urinary concentration of testosterone-glucuronide and hence this genotype exerts a large impact on the testosterone/epitestosterone (T/E) ratio, a biomarker for testosterone doping. The objective of this study was to assess if DNA isolated from athletes urine samples (n = 713) obtained in routine doping controls could be targeted for genotyping analysis for future integration in the athlete's passport. A control population (n = 21) incl...

Lowered phase transition temperature and excellent solar heat shielding properties of well-crystallized VO2 by W doping.

Monoclinic VO2 (M) is a key material for energy-efficient smart window applications. Fine crystalline VO2 particles with an ambient phase transition temperature are urgently required to achieve excellent properties including high luminous transmittance and solar heat shielding ability. Moreover, the anti-oxidation ability is regarded as a significant factor which determines the lifetime of VO2-based products. In this paper, well-crystallized W-doped VO2 with low phase transition temperature, excellent solar...

Point-of-Care Testing of Troponin Levels Compared With Automated Laboratory Evaluation: A Reliability Study.

Traditionally, troponin levels are measured in the blood using an automated laboratory protocol, but the use of a faster technology, the point-of-care (POC) testing of troponin levels, has shown promise in the effective differential diagnosis of cardiac injury. The purpose of this study was to compare the 2 methods. A total of 1567 patients were seen in the emergency department who were tested with both the POC iSTAT troponin and laboratory troponin from a secondary analysis of retrospective data collected ...

Coexistence of anti-β2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies suggests strong thrombotic risk.

Highly specific assays for measuring antiphospholipid antibodies (aPLs) are required for accurate assessment of thrombotic risk. aPLs against β2-glycoprotein I domain I (anti-β2GPIdI) and against prothrombin complexed with phosphatidylserine (anti-PS/PT) have been recently identified as being associated with a hypercoagulable state. This study evaluated the synergism between anti-β2GPIdI and anti-PS/PT for predicting thrombotic events.

Covalent Nitrogen Doping and Compressive Strain in MoS2 by Remote N2 Plasma Exposure.

Controllable doping of two-dimensional materials is highly desired for ideal device performance in both hetero- and p-n homo-junctions. Herein, we propose an effective strategy for doping of MoS2 with nitrogen through a remote N2 plasma surface treatment. By monitoring the surface chemistry of MoS2 upon N2 plasma exposure using in-situ X-ray photoelectron spectroscopy, we identified the presence of covalently bonded nitrogen in MoS2, where substitution of the chalcogen sulfur by nitrogen is determined as th...

Profile of human anti-rabies treatment in the 'agreste' region of Pernambuco State, Brazil, 2010-2012.

to describe the characteristics of reported human anti-rabies treatment in municipalities of the 'agreste' region of Pernambuco State, Brazil, 2010-2012.

Jamaica, Three Years Later: Effects of Intensified Pro-Gay Activism on Severe Prejudice Against Lesbians and Gay Men.

Jamaica has developed an international reputation for severe anti-gay prejudice. However, in the past few years, between 2012 and 2015, intensified waves of activism have increased the visibility of lesbian, gay, bisexual, and transgender (LGBT) Jamaicans, and supported their social and legal inclusion in Jamaican society. This research investigated the effects of that activism by taking advantage of two large, representative surveys of Jamaicans' attitudes toward lesbians and gay men: one in 2012 and one i...

Risk analysis of the preanalytical process based on quality indicators data.

Improving quality and patient safety in the medical biochemistry laboratory accredited according to the International Standard Organization (ISO 15189:2012) requires the patient-centered evaluation of errors based on the implementation of quality indicators (QIs) across the total testing process. Our main goal was to achieve quality improvement of the preanalytical process in an emergency laboratory which had the highest error rate using risk management principles.

Evaluation of LIAISON® XL system for HBsAg, and anti-HCV and anti-HIV/Ag p24.

The aim of this study was to compare the data obtained using the new LIAISON® XL chemiluminescence system to search for HBsAg, anti-HCV and anti-HIV1-2/p24 Ag with those obtained using the VITROS system currently adopted by the Microbiology Unit of the Hospital of Legnano. Routine samples of patients who were referred by practitioners for the determination of HBsAg (1000 samples) and/or anti-HCV (1002 samples) and/or anti-HIV1-2 (995 samples) were simultaneously analysed using both systems. The concordant ...

Laboratory-based surveillance of Clostridium difficile strains circulating in the Australian healthcare setting in 2012.

Clostridium difficile infection (CDI) has risen in prominence in Australia recently. We conducted laboratory-based surveillance of CDI to examine C. difficile circulating in Australia in October/November 2012. We collected 542 isolates from all States and Territories of Australia except the Northern Territory. The most common ribotypes (RTs) were RTs 014/020 (25.5%), 002 (10.5%), 056 (5.9%) and 070 (4.2%). The survey results were compared with results from a similar Australian survey conducted in 2010. Pro...

Strategies that athletes use to avoid detection of androgenic-anabolic steroid doping and sanctions.

Androgenic-anabolic steroids (AAS) are potent and widely used performance-enhancing substances (PES). Since the International Olympic Committee (IOC) began testing athletes for AAS in the 1970s, athletes and their teams have endeavored to beat the system to avoid doping violations and/or sanctions derived from positive test results. This review will discuss the strategies used to avoid detection based on the pharmacology, biochemistry, and genetics of AAS metabolism and testing principles. Another strategy ...

Detection of the diuretic hydrochlorothiazide in a doping control urine sample as the result of a non-steroidal anti-inflammatory drug (NSAID) tablet contamination.

Hydrochlorothiazide (HCTZ, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide) belongs to the class of diuretic agents that represent one of today's cornerstones of the treatment of hypertensive patients. In addition to its clinical relevance, HCTZ is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA) at all times and has frequently been detected in sports drug testing urine samples worldwide since its ban was introduced in 1988. Despite these fact...

Establishing a reference interval for serum anti-dsDNA antibody: A large Chinese Han population-based multi-center study.

A reference interval (RI) for the circulating concentration of anti-dsDNA antibody is essential for clinicians to interpret laboratory results and make clinical decisions. Therefore, we aimed to establish the RI for anti-dsDNA antibody in the Chinese Han population.

Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity.

Given the expected increase in the number of patients with osteoporosis and fragility fractures it is important to have concise information on trends in prescription rates of anti-osteoporosis drugs (AOD).

Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents.

Anti-vascular endothelial growth factor (VEGF) intravitreal agents are the only successful treatment for wet age-related macular degeneration (AMD). However, there are emerging signals that anti-VEGF treatment can potentially increase development of geographic atrophy (GA). Histopathologic, animal, and clinical studies support this hypothesis although direct proof of a relationship between GA and use of anti-VEGF agents in neovascular AMD is not yet established. This review presents current evidence support...

Application of HBOCs electrophoretic method to detect a new blood substitute derived from the giant extracellular hemoglobin of lugworm.

Manipulation of blood and blood components is prohibited in sports by the World Anti-Doping Agency (WADA). This includes the use of blood substitutes to increase oxygen transport, like hemoglobin-based oxygen carriers (HBOCs), which are compounds derived from hemoglobin. Despite their medical interest, the first generation of HBOCs had serious adverse effects and was abandoned. However, new studies are now exploiting the properties of marine worm hemoglobins, which circulate as giant extracellular complexes...

Augmentation of anti-simian immunodeficiency virus activity in CD8+ cells by neutralizing but not nonneutralizing antibodies in the acute phase.

Determination and confirmation of selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors in bovine and porcine urine using UHPLC-MS/MS.

Selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors are prohibited in human sports doping. However, they also present a risk of being used illegally in animal husbandry for fattening purposes. A method was developed and validated using UHPLC-MS/MS for the determination and confirmation of SERMs, anti-estrogens and aromatase inhibiters in bovine and porcine urine. This method was used in a survey of more than 200 bovine and porcine urine samples from Dutch farms. In 18 out...

Efficient nitrogen doping of single-layer graphene accompanied by negligible defect generation for integration into hybrid semiconductor heterostructures.

While doping enables application-specific tailoring of graphene properties, it can also produce high defect densities that degrade the beneficial features. In this work, we report efficient nitrogen doping of ~ 11 at% without virtually inducing new structural defects in the initial, large-area, low defective, and transferred single-layer graphene. To shed light on this remarkable high doping - low disorder relationship, a unique experimental strategy consisting in analyzing the changes in doping, strain, an...

Tunable luminescence and enhanced photocatalytic activity for Eu(III) doped Bi2WO6 nanoparticles.

A series of Eu(III) doped Bi2WO6 nanoparticles were synthesized by a hydrothermal process. The obtained Bi2WO6:Eu(III) nanoparticles were characterized by XRD, SEM, luminescence spectrophotometer and DRS. The XRD and TEM results indicate that the Eu(III) doping concentration has no influence on the phase and morphology. However, the Eu(III) doping can tune the luminescence and enhance the photocatalytic activity of Bi2WO6. With the increases of Eu(3+) doping concentrations, the emission intensity of WO6(6-)...

Earthworm extract attenuates silica-induced pulmonary fibrosis through Nrf2-dependent mechanisms.

Silicosis is an occupational pulmonary fibrosis caused by inhalation of silica (SiO2) and there are no ideal drugs to treat this disease. Earthworm extract (EE), a natural nutrient, has been reported to have anti-inflammatory, antioxidant, and anti-apoptosis effects. The purpose of the current study was to test the protective effects of EE against SiO2-induced pulmonary fibrosis and to explore the underlying mechanisms using both in vivo and in vitro models. We found that treatment with EE significantly red...


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