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15:13 EDT 27th August 2014 | BioPortfolio

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Showing "London 2012 Unveils Anti Doping Laboratory" PubMed Articles 1–25 of 13,000+

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An Afterword HUMANING … (Anti-)DOPING Looking at "doping" sideways (1.)

This trek and quest explores a range of man-made anomalies and challenges which are rarely considered by their stakeholders in the complex, dynamic, nonlinear, multi-dimensionalities of both "doping" and antidoping, closure-driven certitudes.

Store doping samples for 10 years to stop sports cheats, say anti-doping bodies.

Update on banned substances 2013.

Doping has been pervasive throughout the history of athletic competitions and has only recently been regulated by organizations such as the World Anti-Doping Agency (WADA), US Anti-Doping Agency (USADA), and the National Collegiate Athletic Association (NCAA). These regulatory bodies were created to preserve fair play and maintain the safety of the participants. Their updated 2013 lists of banned substances and practices include a variety of drugs and practices that could cause harm to an athlete or give on...

Time for change: a roadmap to guide the implementation of the World Anti-Doping Code 2015.

A medical and scientific multidisciplinary consensus meeting was held from 29 to 30 November 2013 on Anti-Doping in Sport at the Home of FIFA in Zurich, Switzerland, to create a roadmap for the implementation of the 2015 World Anti-Doping Code. The consensus statement and accompanying papers set out the priorities for the antidoping community in research, science and medicine. The participants achieved consensus on a strategy for the implementation of the 2015 World Anti-Doping Code. Key components of this...

hGH isoform differential immunoassays applied to blood samples from athletes: Decision limits for anti-doping testing.

To detect hGH doping in sport, the World Anti-Doping Agency (WADA)-accredited laboratories use the ratio of the concentrations of recombinant hGH ('rec') versus other 'natural' pituitary-derived isoforms of hGH ('pit'), measured with two different kits developed specifically to detect the administration of exogenous hGH. The current joint compliance decision limits (DLs) for ratios derived from these kits, designed so that they would both be exceeded in fewer than 1 in 10,000 samples from non-doping athlete...

Challenges and threats to implementing the fight against doping in sport.

Prominent doping cases in certain sports have recently raised public awareness of doping and reinforced the perception that doping is widespread. Efforts to deal with doping in sport have intensified in recent years, yet the general public believes that the 'cheaters' are ahead of the testers. Therefore, there is an urgent need to change the antidoping strategy. For example, the increase in the number of individual drug tests conducted between 2005 and 2012 was approximately 90 000 and equivalent to an incr...

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GENES IN SPORT AND DOPING.

Genes control biological processes such as muscle production of energy, mitochondria biogenesis, bone formation, erythropoiesis, angiogenesis, vasodilation, neurogenesis, etc. DNA profiling for athletes reveals genetic variations that may be associated with endurance ability, muscle performance and power exercise, tendon susceptibility to injuries and psychological aptitude. Already, over 200 genes relating to physical performance have been identified by several research groups. Athletes' genotyping is deve...

Health Education England unveils its 2014-29 framework.

PATIENTS OF the future will require more care delivered closer to home by a more integrated and flexible workforce, according to Health Education England (HEE).

Drug-drug interaction and doping, part 1: An in vitro study on the effect of non-prohibited drugs on the phase I metabolic profile of toremifene.

The present study was designed to provide preliminary information on the potential impact of metabolic drug-drug interaction on the effectiveness of doping control strategies currently followed by the anti-doping laboratories to detect the intake of banned agents. In vitro assays based on the use of human liver microsomes and recombinant CYP isoforms were designed and performed to characterize the phase I metabolic profile of the prohibited agent toremifene, selected as a prototype drug of the class of sele...

Doping Dependence of the Raman Spectrum of Defected Graphene.

We investigate the evolution of the Raman spectrum of defected graphene as a function of doping. Polymer electrolyte gating allows us to move the Fermi level up to 0.7eV, as directly monitored by in-situ Hall-effect measurements. For a given number of defects, we find that the intensities of the D and D' peaks decrease with increasing doping. We assign this to an increased total scattering rate of the photoexcited electrons and holes, due to the doping-dependent strength of electron-electron scattering. We...

The Athlete Biological Passport: an integral element of innovative strategies in antidoping.

Concern for the health of athletes and integrity of sport resulted in the banning of specific substances although many years passed before analytical testing took place. Soon doping control programmes became synonymous with urine tests and adverse analytical findings. This system has its limits due to the detection window of prohibited substances, the timing of sample collections and the sophistication of some doping regimens. There have been a number of situations where these limits were demonstrated by at...

Doping effects on ablation enhancement in femtosecond laser irradiation of silicon.

We have conducted an experimental investigation on highly efficient femtosecond laser micromachining of silicon through N-type doping. We found that the material removal amount has a close relationship with the doping concentration rather than with the doping types. The amount of material removal was enhanced gradually as doping densities increased. When the doping density reached higher than 1018  cm-3, the ablation threshold was considerably reduced, up to 15%-20%. The results of the experiment indica...

Introduction of solid-phase microextraction as a high-throughput sample preparation tool in laboratory analysis of prohibited substances.

A fully automated, high-throughput method based on thin-film solid-phase microextraction (SPME) and liquid chromatography-mass spectrometry was developed for simultaneous quantitative analysis of 110 doping compounds, selected from ten classes and varying in physical and chemical properties. Among four tested extraction phases, C18 blades were chosen, as they provided optimum recoveries and the lowest carryover effect. The SPME method was optimized in terms of extraction pH, ionic strength of the sample, wa...

Affinity-based biosensors in sport medicine and doping control analysis.

Affinity-based biosensors (ABBs) have started to be considered in sport medicine and doping control analysis because they are cheap, easy to use and sufficiently selective analytical devices, characterized by a reversible interaction with the analyte under investigation allowing the use of the same sensor for multiple analyses. In this review we describe the main categories of substances reported in the World Anti-Doping Agency Prohibited List and how ABBs may contribute to their detection. Although several...

Drawing the map to implement the 2015 World Anti-Doping Code.

Radiology reporting of adrenal incidentalomas - who requires further testing?

Adrenal incidentalomas (AIs) are common and guidelines recommend testing to exclude functioning lesions and malignancy. Their increasing prevalence results in several investigations that are usually conducted in the endocrinology clinic. In 2011, we audited the prevalence and management of AIs identified on computed tomography (CT) imaging of abdomen over 1 calendar month. Consequently, a decision pathway for adrenal lesions was introduced in the radiology department of the Royal Free London Hospital. One y...

Cluster of influenza A cases in vaccinated population of adults in Virology Laboratory in Glasgow in December 2012.

The majority of influenza infections during the 2012/2013 influenza season in Scotland have been due to influenza A H3N2. We report an outbreak of influenza A H3N2 in a vaccinated population of adults in the Regional Virology Laboratory in Glasgow. This investigation was carried out to confirm the epidemiological link between cases.

Pertussis seroprevalence in korean adolescents and adults using anti-pertussis toxin immunoglobulin g.

This study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy adolescents and adults 11 yr of age or older were collected between July 2012 and December 2012, and anti-pertussis toxin (PT) IgG titers were measured using a commercial ELISA kit. We compared the mean anti-PT IgG titers and seroprevalence of pertussis of the six age groups: 11-20, 21-30, 31-40, 41-50, 51-60, a...

Radical-assisted chemical doping for chemically derived graphene.

Carrier doping of graphene is one of the most challenging issues that needs to be solved to enable its use in various applications. We developed a carrier doping method using radical-assisted conjugated organic molecules in the liquid phase and demonstrated all-wet fabrication process of doped graphene films without any vacuum process. Charge transfer interaction between graphene and dopant molecules was directly investigated by spectroscopic studies. The resistivity of the doped graphene films was drastica...

Structural Improvement of CaFe2O4 by Metal Doping toward Enhanced Cathodic Photocurrent.

Various metal-doped p-type CaFe2O4 photocathodes were prepared in an attempt to improve the low quantum efficiency for photoreaction. CuO and Au doping enhanced the photocurrent by expansion of the absorption wavelength region and plasmon resonance, respectively. X-ray diffraction (XRD) and X-ray absorption fine structure (XAFS) analysis showed that doping with these metals further disturbed the originally distorted crystal structure of CaFe2O4. In contrast, doping with Ag relaxed the distorted crystal stru...

Doping Induced Structural Stability and Electronic Properties of GaN Nanotubes.

The present paper discusses the effect of manganese doping on the structural stability and electronic band gap of chiral (2, 1), armchair (3, 3), and zigzag ((6, 0) and (10, 0)) single walled GaN nanotube by using density functional theory based Atomistix Toolkit (ATK) Virtual NanoLab (VNL). The structural stability has been analyzed in terms of minimum ground state total energy, binding, and formation energy. As an effect of Mn doping (1-4 atoms), all the GaN nanotubes taken into consideration show semicon...

Tunable band gap and doping type in silicene by surface adsorption: towards tunneling transistors.

By using first-principles calculations, we predict that a sizable band gap can be opened at the Dirac point of silicene without degrading silicene's electronic properties with n-type doping by Cu, Ag, and Au adsorption, p-type doping by Ir adsorption, and neutral doping by Pt adsorption. A silicene p-i-n tunneling field effect transistor (TFET) model is designed by the adsorption of different transition metal atoms on different regions of silicene. Quantum transport simulations demonstrate that silicene TFE...

Trauma and Organizations . Edited by Earl Hopper , Ph.D. London : Karnac Books , 2012 , 336 pp., paperback, £24.74/$44.05 .

Controllable Synthesis of Doped Graphene and Its Applications.

Graphene is a wonder material with the ultimate smallest thickness that is readily accessible to various approaches for engineering its excellent properties. Graphene doping is an efficient way to tailor its electric properties and expand its applications. This topic covers wide research fields and has been developing rapidly. This article presents a broad and comprehensive overview of the developments in the preparation and applications of doped graphene including doping methods, doping levels, doping effe...

Comparison of two blanket surveys of arsenic in tubewells conducted 12years apart in a 25km(2) area of Bangladesh.

The arsenic (As) content of groundwater pumped from all tubewells within 61 contiguous villages of Araihazar, Bangladesh, was determined a first time in 2000-01 with laboratory measurements and a second time in 2012-13 using the ITS Arsenic Econo-Quick kit. The two surveys indicate that the total number of tubewells within the area almost doubled from 5560 to 10,879 over 12years. The evolution of the distribution of well ages between the two surveys is consistent with a simple model that combines an annual...


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