A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers

22:22 EDT 1st October 2014 | BioPortfolio

Summary

This is a randomized (1:1), prospective, open label, multicenter, comparative study to be examine the effectiveness of Collagen-ORC Antimicrobial matrix, a new wound dressing, on venous leg ulcers.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Leg Ulcer

Intervention

Collagen ORC Antimicrobial Matrix (CAM)

Location

Wound Care Center
Ft Lauderdale
Florida
United States

Status

Completed

Source

Ethicon, Inc.

Results (where available)

View Results

Links

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The purpose of this study is to determine whether the OculusGen Collagen Matrix are effective and safe to implant as an aid of glaucoma surgery.

PubMed Articles [5738 Associated PubMed Articles listed on BioPortfolio]

Shrinking Mechanism of a Porous Collagen Matrix Immersed in Solution.

The porous structure of collagen-based matrices enables the infiltration of cells both in in vitro and clinical applications. Reconstituted porous collagen matrices often collapse when they are in con...

Inhibition of Fibronectin Deposition Improves Experimental Liver Fibrosis.

Common pathogenic steps in liver fibrosis are inflammation and accumulation of extracellular matrix proteins including collagen, which lead to disruption of tissue microarchitecture and liver dysfunct...

Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation.

We have recently described an assay for imaging interstitial collagen degradation in vivo, which allows for the identification of cell types and molecules involved in collagen turnover in the course o...

Corneal collagen cross-linking in a late-onset graft infectious ulcer: a case report.

Infectious keratitis following penetrating keratoplasty is a common postoperative complication. Intensive topical and systemic treatments do not always prevent the risk of graft failure. In this repor...

Venous ulcer care: which dressings are cost effective?

Healed or open venous ulcers may be present in up to 1% of Western populations and consume a large amount of healthcare resources. These ulcers are characterized by a chronic inflammatory environment ...

Medical and Biotech [MESH] Definitions

An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.

A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.

A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.

Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.

An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)

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