Biomarkers of Efficiency of Acceptance and Commitment Therapy in Suicidal Behavior

2016-10-19 02:38:21 | BioPortfolio


Suicidal behaviors (SB) are a major health problem in France:10,000 suicides and 220,000 suicide attempts every year. SB management is therefore a major public health issue. Recently, investigators have demonstrated the interest of acceptance and commitment therapy (ACT) as an add-on treatment to reduce intensity and severity of suicidal ideation in depressed patients having a history of suicide attempt within previous year (i.e actual SB disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5)). Based on structural and functional findings, it is admitted orbitofrontal and ventral prefrontal cortices play a role in suicidal vulnerability. Interestingly, previous functional MRI (fMRI) studies have also reported the modulation of these regions by ACT in subjects suffering from chronic pain. fMRI could thus be an interesting tool to identify biomarkers of SB and its improvement by ACT.

The aim of study is to investigate neural biomarkers of ACT efficiency in patients with SB disorder. Patients having a history of SB within previous year were randomized in an ACT program (21 patients) or relaxation program (21 patients) during 7 weeks. Before and after the completion of the group, they performed 3 tasks during fMRI: implicit emotional visualization, Cyberball game, motivational task Investigators will compare cerebral activations between groups, between pre and post intervention as well as measure baseline cerebral activations associated with improvement of suicidal ideation during follow up.


42 patients having a history of suicide attempt within the year preceding inclusion have been recruited.

First visit or inclusion (within 2 weeks preceding the beginning of the program): clinical, biological assessment and fMRI acquisition Second visit (within 2 weeks +/- 1 week following completion of the program): clinical assessment and fMRI acquisition Third visit (within 3 months +/- 2 weeks following completion of the program): clinical assessment

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator)


Actual Suicidal Behavior Disorder


Relaxation, ACT therapy


Montpellier Hospital University


Active, not recruiting


University Hospital, Montpellier

Results (where available)

View Results


Published on BioPortfolio: 2016-10-19T02:38:21-0400

Clinical Trials [1467 Associated Clinical Trials listed on BioPortfolio]

Suicidal Behavior in African Americans With Bipolar Disorder

The purpose of this study is to learn the environmental and psychological factors that impact suicidality in African-American adults with Bipolar Disorder. Additionally, the study aims to ...

Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder

This study will compare the effectiveness of two treatments, dialectical behavior therapy versus fluoxetine with clinical management, for reducing the risk of self-injury and suicidal beha...

Functional Neuroimaging and Genetic Vulnerability to Suicidal Behavior

The main objective is to highlight, by functional imaging (MRI) dysfunctional brain regions associated with vulnerability to suicidal behavior.

Treatment of Suicidal Women With Borderline Personality Disorder

This study will compare three different therapies to determine which is most effective in treating suicidal women with borderline personality disorder.

Comparing the Effectiveness of Two Family-Based Therapies in Treating Young Children With Obsessive-Compulsive Disorder

This study will compare the effectiveness of family-based cognitive behavioral therapy to family-based relaxation therapy in treating young children with obsessive-compulsive disorder.

PubMed Articles [21379 Associated PubMed Articles listed on BioPortfolio]

Adapting Dialectical Behavior Therapy for the Treatment of Dissociative Identity Disorder.

Dialectical Behavior Therapy (DBT), created by Marsha Linehan, has been shown to be an effective therapy for the treatment of borderline personality disorder (BPD) and for suicidal and self-harming be...

A Randomized Trial of Dialectical Behavior Therapy in High-Risk Suicidal Veterans.

Despite advances in suicide prevention implemented throughout the US Department of Veterans Affairs (VA) including the hiring of Suicide Prevention Coordinators (SPCs) at every VA hospital, enhanced m...

Non-suicidal self-injury and frequency of suicide attempts: The role of pain persistence.

Non-suicidal self-injury (NSSI) and suicidal behavior exhibit a robust association with one another. Research on the contexts within which this relationship is stronger or weaker, however, is limited....

Suicidal Ideation Persists Among Individuals Engaged in HIV Care in the Era of Antiretroviral Therapy.

Little research has focused on suicidality in the era of successful antiretroviral therapy among those engaged in HIV care. We performed a study of 648 clinic patients who completed a psychological an...

Depressive symptoms and suicidal behavior after first-episode psychosis: A comprehensive systematic review.

Depressive symptoms and suicidal behavior are common among patients that suffered a first-episode psychosis. We searched Web of Knowledge(SM) and Pubmed® for English and Portuguese original articles ...

Medical and Biotech [MESH] Definitions

A risk factor for suicide attempts and completions, it is the most common of all suicidal behavior, but only a minority of ideators engage in overt self-harm.

A behavior therapy technique in which deep muscle relaxation is used to inhibit the effects of graded anxiety-evoking stimuli.

The use of mental images produced by the imagination as a form of psychotherapy. It can be classified by the modality of its content: visual, verbal, auditory, olfactory, tactile, gustatory, or kinesthetic. Common themes derive from nature imagery (e.g., forests and mountains), water imagery (e.g., brooks and oceans), travel imagery, etc. Imagery is used in the treatment of mental disorders and in helping patients cope with other diseases. Imagery often forms a part of HYPNOSIS, of AUTOGENIC TRAINING, of RELAXATION TECHNIQUES, and of BEHAVIOR THERAPY. (From Encyclopedia of Human Behavior, vol. 4, pp29-30, 1994)

A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.

The application of modern theories of learning and conditioning in the treatment of behavior disorders.

More From BioPortfolio on "Biomarkers of Efficiency of Acceptance and Commitment Therapy in Suicidal Behavior"

Quick Search

Relevant Topics

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Searches Linking to this Trial