Myo-inositol and Melatonin in Pre-menopausal Women

09:13 EST 22nd December 2014 | BioPortfolio

Summary

The purpose of this study is to determine whether myo-inositol and melatonin, or myo-inositol alone, or melatonin alone, are effective in normalizing irregular bleeding and anovulatory cycles in pre-menopausal women.

Description

Melatonin has produced a remarkable significant improvement of thyroid function, positive changes of gonadotropins towards reduced levels, and in some women a re-acquisition of normal menstrual cycle. Furthermore, an abrogation of menopause-related depression, amelioration of hot-flashes and improvement of quality and duration of sleep has been reported.

Myo-inositol is involved in several aspects of human reproduction. Elevated concentrations of myo-inositol in human follicular fluids appear to play a positive function in follicular maturity and provide a marker of good quality oocytes. Nevertheless its positive role in PCOS women is a consequence of a defect in the insulin signalling pathway (inositol-containing phosphoglycan mediators) that seems to be primarily implicated in the pathogenesis of insulin resistance

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Pre-menopausal Irregular Cycles and Bleedings

Intervention

melatonin, myo-inositol, melatonin plus myo-inositol

Location

University Hospital
Messina
Italy
98100

Status

Recruiting

Source

University of Messina

Results (where available)

View Results

Links

Clinical Trials [327 Associated Clinical Trials listed on BioPortfolio]

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The primary focus of this five-year study will be to optimize the melatonin dosing regimen for synchronizing the body clocks of blind children to the 24-hour day.

Myo-inositol Versus Metformin Administration in Post-menopausal Women With Metabolic Syndrome

Myo-Inositol is classified as a member of the vitamin B complex. It is a constituent of living cells and is widespread in many food. It is involved in a number of biological processes, inc...

Single Dose Intravenous Inositol Pharmacokinetics in Preterm Infants

This pilot study was a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematur...

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Melatonin is a hormone that regulates some body functions, including the sleep/wake cycle. Some people take melatonin supplements (over the counter) for promoting sleep. Some studies sugg...

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PubMed Articles [1882 Associated PubMed Articles listed on BioPortfolio]

An update on the use of melatonin as a stroke therapeutic.

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myo-Inositol 1,3-acetals as early intermediates during the synthesis of cyclitol derivatives.

Synthetic sequences starting from commercially available myo-inositol necessarily involve protection-deprotection strategies of its six hydroxyl groups. Several strategies have been developed/attempte...

Inositol: history of an effective therapy for Polycystic Ovary Syndrome.

Inositol is a physiological compound belonging to the sugar family. The two inositol stereoisomers, myo-inositol and D-chiroinositol are the two main stereisomers present in our body. Myo-inositol is ...

Transcriptional Regulation of Programmed Hypertension by Melatonin: An Epigenetic Perspective.

Melatonin is an endogenously produced indoleamine and secreted by the pineal gland. Melatonin has pleiotropic bioactivities and is involved in epigenetic regulation. Suboptimal conditions during mater...

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Medical and Biotech [MESH] Definitions

A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.

A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.

Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.

A melatonin receptor subtype that is primarily found in the HYPOTHALAMUS and in the KIDNEY.

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