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Role of CXCR2 Ligands/CXCR2 Biological Axis in Pancreatic Cancer

09:34 EDT 24th April 2014 | BioPortfolio

Summary

The investigators hypothesize that the CXCR2 ligands/CXCR2 biological axis plays an important role in promoting angiogenesis in PC; and that the genetic changes and the microenvironment of the tumor regulate the expression of CXCR2 ligands/CXCR2 in PC in order to potentiate their angiogenic phenotype. A corollary of this hypothesis is that the cell surface receptors (CXCR2) and the intracellular signaling pathways that mediate the angiogenic responses induced by ELR+ CXC-chemokines are potential targets for novel therapeutic interventions in PC.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Chronic Pancreatitis

Location

Mayo Clinic
Jacksonville
Florida
United States
32224

Status

Active, not recruiting

Source

Mayo Clinic

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Acute or chronic INFLAMMATION of the PANCREAS due to excessive ALCOHOL DRINKING. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.

INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.

Cyst-like space not lined by EPITHELIUM and contained within the PANCREAS. Pancreatic pseudocysts account for most of the cystic collections in the pancreas and are often associated with chronic PANCREATITIS.

A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.

Clinical Trials [71 Associated Clinical Trials listed on BioPortfolio]

Role of Antioxidants Supplementation in Chronic Pancreatitis

Chronic pancreatitis is a progressive inflammatory disease of the pancreas that presents with abdominal pain and in late stages may cause diabetes and malnutrition. The pain may be incapac...

Percutaneous Lesioning Splanchnic Nerves in Patients With Chronic Pancreatitis

Chronic pancreatitis is a progressive inflammatory disease resulting in slow destruction of the pancreas. This chronic inflammation can lead to chronic abdominal pain which can last for ma...

Safety and Efficacy Study of Thalomid in Patients With Chronic Pancreatitis

The purpose of this study is to determine if Thalidomide (Thalomid) is effective in treating patients with chronic pancreatitis.

Safety And Efficacy Of Tanezumab In Patients With Chronic Pancreatitis

Tanezumab is effective in reducing the pain associated with chronic pancreatitis.

Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis

The objective is to evaluate the dietary nitrogen assimilation and metabolic utilisation capability of patients with chronic pancreatitis.

PubMed Articles [5226 Associated PubMed Articles listed on BioPortfolio]

Altered resting state EEG in chronic pancreatitis patients: toward a marker for chronic pain.

Electroencephalography (EEG) may be a promising source of physiological biomarkers accompanying chronic pain. Several studies in patients with chronic neuropathic pain have reported alterations in cen...

Antioxidants Are Not Useful in Reducing Both Pain and Inflammation in Chronic Pancreatitis.

Pain is the main clinical symptom of chronic pancreatitis at its early stages; then the pain tends to disappear during the progression of the disease. Several options have been proposed to treat pain...

Diabetes increases pancreatic fibrosis during chronic inflammation.

Diabetes and fibrosis can be concurrent processes in several diseases such as cystic fibrosis or chronic pancreatitis. To evaluate whether diabetes can influence fibrosis and thus aggravate the pathol...

Mortality, Cancer, and Comorbidities Associated with Chronic Pancreatitis-a Danish Nationwide Matched-Cohort Study.

We aimed to assess the risk of death, cancer, and comorbidities among patients with alcoholic and non-alcoholic chronic pancreatitis (CP).

Diagnosis of chronic pancreatitis according to miagnetic resonance imaging data.

To estimate the informative value of magnetic resonance imaging (MRI) and MR cholangiopancreatography for diagnosing changes in the parenchyma and duct system of patients with suspected and/or diagnos...

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