Acute Pain and Inflammation After Surgery

08:39 EST 20th December 2014 | BioPortfolio

Summary

The purpose of this study is

1. to observe acute pain after surgery and measure the natural course of inflammatory mediators

2. study pain relieving effects and local anti-inflammatory effects of systemically administered ketorolac

Description

Randomizized controlled trial

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatm

Conditions

Acute Pain

Intervention

1 Ketorolac intraarticular, Placebo

Location

Rikshospitalet-Radiumhospitalet HF
Oslo
Norway
0027

Status

Recruiting

Source

Rikshospitalet HF

Results (where available)

View Results

Links

Clinical Trials [1375 Associated Clinical Trials listed on BioPortfolio]

Postoperative Analgesia After Total Knee Arthroplasty

Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain. Although epidural treatment provides good and reliable postoperative pain relief after THA, it may c...

Preoperative Intraarticular Injection of Methylprednisolone in Patients Scheduled for Total Knee-arthroplasty

Despite improvements in analgesic treatment following total knee arthroplasty (TKA) for osteoarthrosis, a substantial part of patients still have severe acute pain after surgery. It has be...

Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy

The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having laparoscopic surgery to donate a kidney.

Effect of Spinal Ketorolac After Acute Opioid Exposure

This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury. Currently available pain ...

Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy

The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having percutaneous nephrolithotomy for kidney stone disease.

PubMed Articles [11095 Associated PubMed Articles listed on BioPortfolio]

Sniffing out pain: An in vivo intranasal study of analgesic efficacy.

Background: Orofacial pain is a common encounter in dentistry (affecting 12% of the population) and is a primary reason for patients seeking emergency care. Dentists often prescribe oral analgesics, w...

Randomized trial of IV valproate vs metoclopramide vs ketorolac for acute migraine.

We compared the efficacy of IV valproate with metoclopramide and with ketorolac in patients presenting to an emergency department (ED) with acute migraine.

The Effect of Intranasal Oxytocin Administration on Acute Cold Pressor Pain: A Placebo-Controlled, Double-Blind, Within-Participants Crossover Investigation.

This study examined the effect of synthetic oxytocin delivered intranasally on acute pain sensitivity using a placebo-controlled, double-blind, within-participant crossover design.

Expectations and positive emotional feelings accompany reductions in ongoing and evoked neuropathic pain following placebo interventions.

Research on placebo analgesia and nocebo hyperalgesia has primarily included healthy subjects or acute pain patients, and it is unknown whether these effects can be obtained in ongoing pain in patient...

Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.

The difference in tissue distribution of Ketorolac and its enantiomers were investigated in wistar rats. Separate high performance liquid chromatographic method was developed and validated for determi...

Medical and Biotech [MESH] Definitions

A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity.

A clinical syndrome with acute abdominal pain that is severe, localized, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.

Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.

Facilities providing diagnostic, therapeutic, and palliative services for patients with severe chronic pain. These may be free-standing clinics or hospital-based and serve ambulatory or inpatient populations. The approach is usually multidisciplinary. These clinics are often referred to as "acute pain services". (From Br Med Bull 1991 Jul;47(3):762-85)

Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.

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