Acute Pain and Inflammation After Surgery

12:27 EDT 23rd May 2015 | BioPortfolio

Summary

The purpose of this study is

1. to observe acute pain after surgery and measure the natural course of inflammatory mediators

2. study pain relieving effects and local anti-inflammatory effects of systemically administered ketorolac

Description

Randomizized controlled trial

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatm

Conditions

Acute Pain

Intervention

1 Ketorolac intraarticular, Placebo

Location

Rikshospitalet-Radiumhospitalet HF
Oslo
Norway
0027

Status

Recruiting

Source

Rikshospitalet HF

Results (where available)

View Results

Links

Clinical Trials [1468 Associated Clinical Trials listed on BioPortfolio]

Postoperative Analgesia After Total Knee Arthroplasty

Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain. Although epidural treatment provides good and reliable postoperative pain relief after THA, it may c...

Preoperative Intraarticular Injection of Methylprednisolone in Patients Scheduled for Total Knee-arthroplasty

Despite improvements in analgesic treatment following total knee arthroplasty (TKA) for osteoarthrosis, a substantial part of patients still have severe acute pain after surgery. It has be...

Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy

The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having laparoscopic surgery to donate a kidney.

Effect of Spinal Ketorolac After Acute Opioid Exposure

This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury. Currently available pain ...

Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy

The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having percutaneous nephrolithotomy for kidney stone disease.

PubMed Articles [10777 Associated PubMed Articles listed on BioPortfolio]

Efficacy and Safety of an Oral Ambroxol Spray in the Treatment of Acute Uncomplicated Sore Throat.

Objective: Compare the efficacy and tolerability of oral spray formulations delivering 2.5, 5, and 10 mg ambroxol (AXS) per application (4 actuations/application) in relieving acute sore throat vs. ...

Expectations and positive emotional feelings accompany reductions in ongoing and evoked neuropathic pain following placebo interventions.

Research on placebo analgesia and nocebo hyperalgesia has primarily included healthy subjects or acute pain patients, and it is unknown whether these effects can be obtained in ongoing pain in patient...

Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.

The difference in tissue distribution of Ketorolac and its enantiomers were investigated in wistar rats. Separate high performance liquid chromatographic method was developed and validated for determi...

Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans.

In rodents, acute exposure to opioids results in transient antinociception followed by longer lasting hypersensitivity to tactile or thermal stimuli, a phenomenon termed opioid-induced hyperalgesia. T...

Efficacy of topical ketorolac for improving visual function after photocoagulation in diabetic patients with focal macular edema.

Background: Photocoagulation reduces the incidence of visual loss in diabetic patients with focal macular edema, but it can induce it for Efficacy of topical ketorolac for improving visual function af...

Medical and Biotech [MESH] Definitions

A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity.

A clinical syndrome with acute abdominal pain that is severe, localized, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.

Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.

Facilities providing diagnostic, therapeutic, and palliative services for patients with severe chronic pain. These may be free-standing clinics or hospital-based and serve ambulatory or inpatient populations. The approach is usually multidisciplinary. These clinics are often referred to as "acute pain services". (From Br Med Bull 1991 Jul;47(3):762-85)

Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.

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