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Diaphragm Plication in Adults With Phrenic Nerve Paralysis

2014-07-24 09:17:30 | BioPortfolio

Summary

The purpose of the study is to investigate the impact of unilateral or bilateral diaphragm plication in a prospective randomised controlled way on symptoms, pulmonary function including gas exchange, respiratory muscle strength, exercise capacity and breathing during sleep in patients with proven uni- or bilateral phrenic nerve paralysis present for at least 1 year without any evidence of spontaneous recovery.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Phrenic Nerve Paralysis

Intervention

diaphragm plication 6 months after inclusion, diaphragm plication at time of inclusion

Location

University Hospital Gasthuisberg Divisionof Pulmonology
Leuven
Belgium
3000

Status

Recruiting

Source

Katholieke Universiteit Leuven

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T09:17:30-0400

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Diaphragm Pacing After Spinal Cord Injury

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Effectiveness of the Diaphragm for HIV Prevention

The purpose of this trial is to determine whether using the diaphragm and a lubricant get can reduce women's risk of acquiring an HIV infection.

Open Label Study of the Safety and Contraceptive Efficacy of BufferGel® With Diaphragm

The purpose of this study is to study the safety and contraceptive effectiveness of BufferGel used with a contraceptive diaphragm.

Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS)

The study is being conducted to determine if DPS treatment for people with ALS and hypoventilation is associated with improved survival or diaphragm function. The primary objective of the...

Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing, a First in Human Trial

Study conducted to confirm phrenic nerve stimulation using the Lungpacer LIVE Catheter, confirm capture of the diaphragm and confirm that the diaphragm can be paced in synchrony with mecha...

PubMed Articles [15196 Associated PubMed Articles listed on BioPortfolio]

Is surgical plication necessary in diaphragm eventration?

Diaphragm plication surgery is conducted to remove dyspnea, which results from mediastinal shift, atelectasia, and ventilation/perfusion dyssynchrony in lungs that occur because of an eventrated diaph...

Thoracoscopic diaphragm plication.

To Sink the Lifted: Selection, Technique, and Result of Laparoscopic Diaphragmatic Plication for Paralysis or Eventration.

Introduction Diaphragmatic eventration is a congenital defect of the muscular portion of a hemidiaphragm that eventually leads to hemidiaphragmatic elevation and dysfunction. The clinical diagnosis ...

The Effects of Doming of the Diaphragm in Subjects With Short-Hamstring Syndrome: A Randomized Controlled Trial.

Taking into account the complex structure of the diaphragm and its important role in the postural chain, the authors were prompted to check the effects of a diaphragm technique on hamstring flexibilit...

Effects of Experimental Human Endotoxemia on Diaphragm Function.

Systemic inflammation is a well-known risk factor for respiratory muscle weakness. Studies utilizing animal models of inflammation have shown that endotoxin administration induces diaphragm dysfunctio...

Medical and Biotech [MESH] Definitions

A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.

A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.

The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.

Soft tissue formed mainly by the pelvic diaphragm, which is composed of the two levator ani and two coccygeus muscles. The pelvic diaphragm lies just below the pelvic aperture (outlet) and separates the pelvic cavity from the PERINEUM. It extends between the PUBIC BONE anteriorly and the COCCYX posteriorly.

The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.

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