Diaphragm Plication in Adults With Phrenic Nerve Paralysis

2014-07-24 09:17:30 | BioPortfolio

Summary

The purpose of the study is to investigate the impact of unilateral or bilateral diaphragm plication in a prospective randomised controlled way on symptoms, pulmonary function including gas exchange, respiratory muscle strength, exercise capacity and breathing during sleep in patients with proven uni- or bilateral phrenic nerve paralysis present for at least 1 year without any evidence of spontaneous recovery.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Phrenic Nerve Paralysis

Intervention

diaphragm plication 6 months after inclusion, diaphragm plication at time of inclusion

Location

University Hospital Gasthuisberg Divisionof Pulmonology
Leuven
Belgium
3000

Status

Recruiting

Source

Katholieke Universiteit Leuven

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T09:17:30-0400

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Open Label Study of the Safety and Contraceptive Efficacy of BufferGel® With Diaphragm

The purpose of this study is to study the safety and contraceptive effectiveness of BufferGel used with a contraceptive diaphragm.

Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS)

The study is being conducted to determine if DPS treatment for people with ALS and hypoventilation is associated with improved survival or diaphragm function. The primary objective of the...

Laparoscopy Versus Clinical and Radiological Follow up to Detect Diaphragm Injury and Herniation, in Patients With Asymptomatic Left Thoracoabdominal Stab Wounds

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Assessing Diaphragm Muscle Inactivity in Mechanically Ventilated ICU Patients

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PubMed Articles [15117 Associated PubMed Articles listed on BioPortfolio]

Is surgical plication necessary in diaphragm eventration?

Diaphragm plication surgery is conducted to remove dyspnea, which results from mediastinal shift, atelectasia, and ventilation/perfusion dyssynchrony in lungs that occur because of an eventrated diaph...

Thoracoscopic plication for idiopathic eventration of the bilateral diaphragm: Report of a case.

Diaphragmatic eventration, defined as permanent elevation of the diaphragm without defects, is a rare anomaly in adults. Trauma, neoplasms, infection, and degenerative disease are the most common caus...

Computed Tomography to Diagnose Blunt Diaphragm Injuries: Not Ready for Prime Time.

Diaphragm injuries after blunt trauma are uncommon but require early diagnosis to expedite repair. The advancing technology of computed tomography (CT) scanners has improved the detection of almost al...

Guiding Intramuscular Diaphragm Injections Using Real-time Ultrasound & Electromyography.

Introduction: We describe a unique method that combines ultrasound and electromyography to guide intramuscular diaphragm injections in anesthetized large animals. Methods: Ultrasound was used to visua...

Effects of Experimental Human Endotoxemia on Diaphragm Function.

Systemic inflammation is a well-known risk factor for respiratory muscle weakness. Studies utilizing animal models of inflammation have shown that endotoxin administration induces diaphragm dysfunctio...

Medical and Biotech [MESH] Definitions

A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.

A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.

The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.

Soft tissue formed mainly by the pelvic diaphragm, which is composed of the two levator ani and two coccygeus muscles. The pelvic diaphragm lies just below the pelvic aperture (outlet) and separates the pelvic cavity from the PERINEUM. It extends between the PUBIC BONE anteriorly and the COCCYX posteriorly.

The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.

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