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Pregabalin (Lyrica) for the Treatment of Restless Legs Syndrome

2014-08-27 03:34:07 | BioPortfolio

Summary

This study will evaluate the safety and efficacy of Pregabalin (Lyrica) in treating patients with Restless Legs Syndrome (RLS) in a double-blind, placebo-controlled trial.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Restless Legs Syndrome

Intervention

Pregabalin (Lyrica), Placebo

Location

University of South Florida
Tampa
Florida
United States
33612

Status

Withdrawn

Source

University of South Florida

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:34:07-0400

Clinical Trials [1144 Associated Clinical Trials listed on BioPortfolio]

Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients

To test the effectiveness and tolerability of Lyrica at various dose levels in RLS patients

Long Term Study Of Pregabalin In Idiopathic Restless Legs Syndrome Patients

This purpose of this study is to investigate the efficacy and tolerability of pregabalin in treating idiopathic RLS patients for up to 12 months.

A Study of Oral Dosing of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients

The objective of this study is to assess the efficacy of once-daily oral administration of Gabapentin enacarbil versus placebo, based on the change in International Restless Legs Syndrome ...

Neuroma Injections to Treat Restless Legs Syndrome - RCT

The purpose of this study is to determine whether, in a randomized, placebo-controlled trial, restless legs syndrome (RLS) can be caused by pinched and damaged foot nerves called neuromas.

Intravenous Iron Metabolism in Restless Legs Syndrome

To determine the effects of high-dose infusions of iron on Restless Legs Syndrome (RLS) symptoms and brain concentrations of iron.

PubMed Articles [5880 Associated PubMed Articles listed on BioPortfolio]

Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese Population.

The aim of the study was to investigate the relationship between genetic factors and primary restless legs syndrome (RLS) in Chinese population.

Refining duration and frequency thresholds of restless legs syndrome diagnosis criteria.

This study assesses the prevalence of restless legs syndrome (RLS) using DSM-5 criteria and determines what is the most appropriate threshold for the frequency and duration of RLS symptoms.

Association of Restless Legs Syndrome With Incident Parkinson's Disease.

The association between restless legs syndrome (RLS) and Parkinson's disease (PD) has been extensively studied with inconclusive results; therefore, we prospectively examined the associations of the p...

Haste makes waste: Decision making in patients with restless legs syndrome with and without augmentation.

To investigate decision making in patients with primary restless legs syndrome (RLS) with and without augmentation treated with dopaminergic medication.

Epilepsy and restless legs syndrome.

Restless legs syndrome (RLS) is a common neurological movement disorder occurring in approximately 10% of the general population. The prevalence of moderately severe RLS is 2.7% overall (3.7% for wome...

Medical and Biotech [MESH] Definitions

A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence. This condition may be associated with UREMIA; DIABETES MELLITUS; and rheumatoid arthritis. Restless Legs Syndrome differs from NOCTURNAL MYOCLONUS SYNDROME in that in the latter condition the individual does not report adverse sensory stimuli and it is primarily a sleep-associated movement disorder. (Adams et al., Principles of Neurology, 6th ed, p387; Schweiz Rundsch Med Prax 1997 Apr 30;86(18):732-736)

A syndrome associated with traumatic injury to the cervical or upper thoracic regions of the spinal cord characterized by weakness in the arms with relative sparing of the legs and variable sensory loss. This condition is associated with ischemia, hemorrhage, or necrosis involving the central portions of the spinal cord. Corticospinal fibers destined for the legs are spared due to their more external location in the spinal cord. This clinical pattern may emerge during recovery from spinal shock. Deficits may be transient or permanent.

Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A condition caused by one or more episodes of DEEP VEIN THROMBOSIS, usually the blood clots are lodged in the legs. Clinical features include EDEMA; PAIN; aching; heaviness; and MUSCLE CRAMP in the leg. When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER.

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Sleep Disorders
Sleep disorders disrupt sleep during the night, or cause sleepiness during the day, caused by physiological or psychological factors. The common ones include snoring and sleep apnea, insomnia, parasomnias, sleep paralysis, restless legs syndrome, circa...


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