Search Results for "Didodecyldimethylammonium Bromide And Cancer"

07:26 EST 26th January 2015 | BioPortfolio

Original Source: Didodecyldimethylammonium bromide (DDAB) induces caspase-mediated apoptosis in human leukemia HL-60 cells.

Didodecyldimethylammonium bromide (DDAB) is widely used for an efficient delivery system into mammalian cells. However, the biological activities of DDAB nanoparticles in mammalian cells are insufficiently understood. The purpose of this study was to establish a critical role of DDAB in cellular response. Here, we demonstrate that DDAB is a potent inducer of cell death in a wide range of tumor cell lines, wherein leukemia cells (HL-60 and U937) and neuroblastoma cells (Neuro2a) were more sensitive to DDAB t...

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Methylnaltrexone bromide (Relistor) for opioid-induced constipation in adult patients with chronic non-malignant pain

Methylnaltrexone bromide (Relistor) is administered subcutaneously (SC) and intended for use as a first or subsequent line therapy for the treatment of opioid-induced constipation in adult patients wi...

Novartis boosts US respiratory portfolio with two COPD filings

Novartis has filed new drug applications (NDAs) for two chronic obstructive pulmonary disease (COPD) drugs: QVA149 (indacaterol/glycopyrronium bromide) and NVA237 (glycopyrronium bromide).

Novartis reports top-line results in COPD trials; NDA acceptance will trigger milestone for Vectura

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Almirall’s aclidinium bromide/formoterol backed by EMA/CHMP to treat COPD

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Almirall’s aclidinium bromide/formoterol fumarate recommended for approval in Europe to treat COPD

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Novartis reports positive Phase III results for QVA149 and NVA237

Novartis announced positive top-line results from the pivotal Phase III clinical trial programs for QVA149 (indacaterol/glycopyrronium bromide) and NVA237 (glycopyrronium bromide) to support New Drug ...

Erythroped Forte, glycopyrronium, Hytrin and methotrexate out of stock

The following products are currently out of stock from Amdipharm Mercury: Erythroped Forte SF (erythromycin ethyl succinate) suspension 500mg/5ml, 140ml x 20, glycopyrronium bromide solution for injec...

FDA advisory committee recommends approval of Tiotropium Respimat COPD

The FDA Pulmonary-Allergy Drugs Advisory Committee (PADAC) voted (10 yes, three no) t/news-online/company/Boehringer+Ingelheimhat existing data supports approval of Boehringer Ingelheim's investigati...

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Magnetically-responsive electrophoretic silica organosols.

Silica nanoparticles can be dispersed in organic solvents (organosols) using surfactants, such as didodecyldimethylammonium bromide (DDAB). DDAB analogs prepared with lathanide tetrahalide counterions...

A critical evaluation of bioimpedance spectroscopy analysis in estimating body composition during GH treatment: comparison with bromide dilution and dual X-ray absorptiometry.

Objective: To compare estimates by Bioimpedance Spectroscopy Analysis (BIS) of extracellular water (ECW), fat mass (FM), and fat free mass (FFM) against standard techniques of bromide dilution and DXA...

Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines.

With the aim of discovering potential cytotoxic agents, a series of benzochromene derivatives were screened for their cytotoxic activity against seven human cancer cell lines by standard 3-(4, 5-dimet...

The Selective Oxidation of Alcohols Using Alkali Metal Bromides as Bromide Catalysts: A Experimental Study of the Reaction Mechanism.

A bromide-catalyzed oxidation of alcohols was developed which proceeded in the presence of an alkali metal bromide and an oxidant under mild conditions. The reaction involved an organic-molecule-free ...

Biomechanics and Thermodynamics of Nanoparticle Interactions with Plasma and Endosomal Membrane Lipids in Cellular Uptake and Endosomal Escape.

To be effective for cytoplasmic delivery of therapeutics, nanoparticles (NPs) taken up via endocytic pathways must efficiently transport across the cell membrane and subsequently escape from the secon...

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