Breast Cancer

Breast cancer in the UK is diagnosed in nearly  46,000 people  each year, with just over 12,000 dying from breast cancer each year in he UK. There are several risk factors for developing b...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian,...

Selective Estrogen Receptor Modulators SERMs

Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ER) agonists or antagonist depending on the targeted tissue and the specific configuration of the used SERM. Effects on bone, e...

Breast Lumps

Antibody Drug Conjugates ADC

The humanized anti-Her2 monoclonal antibody Herceptin (trastuzumab) has become the mainstay in the treatment of Her2-positive breast cancer. Combining trastuzumab with the potent cytotoxic DM1 via a s...

Density Of Breasts Does Not Impact Death Among Breast Cancer Patients

A study featured in the August 20 edition in the Journal of the National Cancer Institute reveals that the risk of mortality from breast cancer is not associated with high mammographic breast density...

Treating HER2+ Breast Cancer With HIV Drug

The HIV protease inhibitor, Nelfinavir, can be used to treat HER2-positive breast cancer in the same capacity and dosage regimen that it is used to treat HIV, according to a study published in the Jou...

Breast cancer… do you know who diagnoses you?

Australian women have a 1 in 9 lifetime risk of developing breast cancer and 1 in every 100 breast cancers occurs in men. In 2012, it is estimated that 14,610 women will be diagnosed with breast canc...

Breast augmentation may hurt breast cancer survival

The weight of evidence from epidemiological studies indicates cosmetic breast implants are not associated with increased risk of breast cancer, but concern remains because implants may impair the ab...

Breast Implants Linked to Poorer Survival From Breast Cancer

Women with breast implants who develop breast cancer have a higher risk of being diagnosed with nonlocalized breast tumors and lower breast-cancer-specific survival, but there are study limitations....

Breast cancer's many drivers

(Broad Institute of MIT and Harvard) Breast cancer is not a single disease, but a collection of diseases with dozens of different mutations that crop up with varying frequency across different breast...

My battle with breast cancer: Diet and exercise

Being overweight adds to your risk of getting breast cancer. It also increases your risk of recurring breast cancer. The problem is that chemo, medications and dealing with cancer suck the energy out...

Breast Cancer Battle - More Genes Discovered

Researchers have discovered nine new genes which are involved in the development of breast cancer, bringing the number of all genes so far associated with the development of breast cancer to 40, accor...

Characterization of the pharmacokinetics of a liposomal formulation of eribulin mesylate (E7389) in mice.

Eribulin mesylate (E7389), a tubulin and microtubule inhibitor, has been approved to treat metastatic breast cancer in certain patient populations. A liposomal formulation of E7389, E7389-LF, aims to...

Eribulin mesylate: a promising new antineoplastic agent for locally advanced or metastatic breast cancer.

More than one million women worldwide are diagnosed with breast cancer every year. For those diagnosed with metastatic breast cancer, the 5-year survival rates are low as, ultimately, patients develop...

Synthesis of Alcohols from m-Fluorophenylsulfones and Dialkylboranes: Application to the C14-C35 Building Block of E7389.

The reaction of m-fluorophenylsulfone anions with dialkylboranes, followed by alkaline hydroperoxide oxidation, yields alcohols in high yields. Optimization of the process, scope and limitation, and a...

The risk of a second primary lung cancer after a first invasive breast cancer according to estrogen receptor status.

PURPOSE: Lung cancers account for 5 % of second primary cancers after breast cancer. The low overall 5-year relative survival rate of lung cancer makes it a particularly concerning new malignancy for...

MRI findings of inflammatory breast cancer, locally advanced breast cancer, and acute mastitis: T2-weighted images can increase the specificity of inflammatory breast cancer.

Inflammatory breast carcinoma (IBC) is rare; however, it is the most aggressive variant of breast cancer with a very poor outcome. Locally advanced breast cancer and acute mastitis have a presentation...