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01:47 EDT 2nd July 2016 | BioPortfolio

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Improvised naloxone nasal sprays lack evidence of absorption and effect

Naloxone hydrochloride is a medication that can reverse the effects of an opioid overdose. First responders (peers, family, police, etc.) may prefer nasal sprays to injectable naloxone, which has led ...

Supine Delivery of OTC Oxymetazoline Nasal Drops Risks Serious Toxicity

One squeeze of 0.05% oxymetazoline nasal spray held at a 45° angle delivers a potentially toxic dose.

Cytokine patterns in nasal secretion of non-atopic patients distinguish between chronic rhinosinusitis with or without nasal polys

Being one of the most common nasal diseases, chronic rhinosinusitis (CRS) is subdivided into CRS with nasal polyps (NP) and CRS without nasal polyps (CRSsNP). CRSsNP presents itself with a TH1 milieu ...

Denervation of nasal mucosa induced by posterior nasal neurectomy suppresses nasal secretion, not hypersensitivity, in an allergic rhinitis rat model

Corticosteroid nasal spray delays treatment in patients with severe nasal obstruction

A mandatory use of corticosteroid nasal spray resulted in delay in treatment for patients with severe-to-extreme nasal obstruction, according to study results published in JAMA Facial Plastic Surgery....

Review article compared over-the-counter nasal dilators

The narrowest area of the nose is the internal nasal valve and obstruction can cause airflow trouble. A review article published online by JAMA Facial Plastic Surgery compares over-the-counter mechani...

Adapt Pharma’s Narcan Nasal Spray now available in U.S.

David SalazarThe nasal spray is an emergency treatment for opioid overdose, and the only naloxone nasal spray approved by the Food and Drug Administration in the United States, according to the compan...

New Research Highlights Efficient in Vitro Strategies for Demonstrating Bioequivalence in Generic Nasal Sprays

Experts from Nanopharm, supported by Malvern instruments and with funding from the Food and Drug Administration (FDA), have carried out experimental studies to identify analytical strategies that can ...

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Cell-Penetrating Peptide Penetratin as a Potential Tool for Developing Effective Nasal Vaccination Systems.

Nasal vaccination is considered an attractive strategy to prevent the infection and spread of viruses. However, the vaccine formulations available on the market remain imperfect on account of their li...

Primary Air Liquid Interface Culture of Nasal Epithelium for Nasal Drug Delivery.

Nasal drug administration is a promising alternative to oral and parenteral administration for both local and systemic delivery of drugs. The benefits include its non-invasive nature, rapid absorption...

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery.

Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intrave...

Mitek Suspension of the Lateral Nasal Wall.

The nasal valve has long been described as the anatomical boundary most likely to inhibit nasal airflow and lead to subsequent nasal obstruction. Although many procedures can address this area to impr...

A Novel Drug Delivery System for the Human Nasal Epithelium.

The epithelium of upper respiratory tissues such as the human nasal mucosa forms a continuous barrier via tight junctions (TJs). The development of a drug delivery system for use across the nasal muco...

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