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Learn about the unique characteristics of tramadol, its pharmacogenomic considerations, and its potential for abuse in this comprehensive review. Anesthesia & Analgesia
μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pa...
The U.S. Department of Health and Human Services (HHS) announced the expansion of access to opioid treatment in order to combat the opioid epidemic in the United States. HHS is growing access to medic...
Opioid users and their friends and families may soon have an app to locate a source of naloxone, the antidote that can stop or reverse the effects of an opioid overdose.
Hard-hit states will receive more funds to combat the opioid crisis as opioid-related deaths continue to surge.
This month, Cigna Corp did away with pre-authorization requirements that had previously stood between those struggling with opioid addiction and treatment, an action that is just one of the many colla...
As unintentional opioid overdose deaths skyrocketed 4 years ago in Massachusetts, a private insurer’s utilization review program apparently stemmed the tide of prescription opioid use among its memb...
In the midst of the opioid epidemic, an estimated 1.5 million Americans seek treatment annually in an effort to avoid the life-threatening effects of opioid use disorder and improve their quality of l...
Opioid use disorders attributed to tramadol (OUD-T) is a public health problem in Egypt. The objective of this study was to assess the psychiatric comorbidity among patients with opioid use disorder a...
Chronic use of opioid medications has been reported to cause altered sexual function. It is not known if non-opioid pain medications have similar effects. Assessment of this effect through the measure...
Tramadol and tapentadol are centrally acting, synthetic opioid analgesics used in the treatment of moderate to severe pain. Main metabolic patterns for these drugs in humans are well characterized. Tr...
Drugs able to treat both nociceptive and neuropathic pain effectively without major side effects are lacking. We developed a bifunctional peptide-based hybrid (KGNOP1) that structurally combines a mu-...
Cognitive impairment is one of the consequences of substance abuse. Tramadol abuse is a public health problem in Egypt. The objective of this study was to estimate the prevalence and correlates of cog...