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μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pa...
The British biotech reports positive results for its opioid dependece treatment as concerns surge in the U.S. about opioid abuse.
Naloxone is an opioid antagonist, used as an "antidote" for opioid overdose which includes heroin, and opioid pain medicines such as morphine, fentanyl and codeine. It has been used since the 1970s by...
The U.S. Department of Health and Human Services (HHS) announced the expansion of access to opioid treatment in order to combat the opioid epidemic in the United States. HHS is growing access to medic...
Opioid users and their friends and families may soon have an app to locate a source of naloxone, the antidote that can stop or reverse the effects of an opioid overdose.
Hard-hit states will receive more funds to combat the opioid crisis as opioid-related deaths continue to surge.
This month, Cigna Corp did away with pre-authorization requirements that had previously stood between those struggling with opioid addiction and treatment, an action that is just one of the many colla...
As unintentional opioid overdose deaths skyrocketed 4 years ago in Massachusetts, a private insurer’s utilization review program apparently stemmed the tide of prescription opioid use among its memb...
Opioid use disorders attributed to tramadol (OUD-T) is a public health problem in Egypt. The objective of this study was to assess the psychiatric comorbidity among patients with opioid use disorder a...
Tramadol and tapentadol are centrally acting, synthetic opioid analgesics used in the treatment of moderate to severe pain. Main metabolic patterns for these drugs in humans are well characterized. Tr...
Cognitive impairment is one of the consequences of substance abuse. Tramadol abuse is a public health problem in Egypt. The objective of this study was to estimate the prevalence and correlates of cog...
The epidemic of opioid abuse is related in part to incomplete understanding of pain-relief management, opioid tolerance, and opioid addiction. Among the prevention strategies are more widespread shari...
Postoperative shivering (POS) is a common complication that occurs after regional and general anesthesia. Thus far, numerous studies have reported on the effectiveness of tramadol in preventing or tre...