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03:39 EDT 29th May 2016 | BioPortfolio

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Safety monitoring of drug interchangeability

When a brand-name drug is going off patent protection, pharmaceutical or generics companies may file an abbreviated new drug application (ANDA) for approval of a generic drug. As indicated by the US F...

In 2015, First-Of-A Kind Drug Approvals On The Rise

This trend reflected an industry-wide focus on drugs for rare and hard-to-treat diseases. Meanwhile, Gilead's hepatitis C combo drug gets a Food and Drug Administration priority review, a gene-editing...

Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery

Pharmacogenomics, the study of how genes influence drug response, has become an increasingly important technique in modern drug discovery. In this Review, Zhou and colleagues discuss the role of pharm...

FDA issues warning about rare, but serious, side effect in Lilly antipsychotic drug

The US Food and Drug Administration (FDA) has issued a new warning to all drug labels for Eli Lilly’s antipsychotic drug, olanzapine. The drug can cause a rare but serious skin reaction, called DRES...

Study Indicates Safety of Shingles Pain Drug

NewsAntiviral drug candidate to prevent shingles-related post-herpetic neuralgia pain received positive results from a drug-drug interaction study.

Meeting Announcement: New Approaches for Predicting Drug Toxicity

Ninth Annual New Approaches for Predicting Drug Toxicity Discovering New Models and Integrating Innovative Strategies June 15-16, 2016  |  Boston, MA WorldPreclinicalCongress.com/Drug-Safety-...

Drug-Drug Interactions With New HCV Medications

Many patients taking direct acting antivirals (DAA) to treat hepatitis C virus (HCV) are at risk of clinically significant drug-drug interactions (DDIs), new research shows. Reuters Health Informati...

Preclinical Drug–Drug Interaction: Risk Assessment and Toxicity

Drug discovery involves using assays to predict potential drug–drug interactions before clinical trials begin, but predicting clinical toxicity is complicated. This eBriefing examines in vivo, i...

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Changes in Drug Use Among Belgian Higher Education Students: A Comparison Between 2005, 2009, and 2013.

Most drug users initiate illicit drug use during adolescence and young adulthood. Although in the general population a trend towards a decrease in drug use can be seen, patterns of drug use among stud...

Do drug seizures predict drug-related emergency department presentations or arrests for drug use and possession?

Direct evidence of the effect of drug seizures on drug use and drug-related harm is fairly sparse. The aim of this study was to see whether seizures of heroin, cocaine and ATS predict the number of pe...

Drug-drug interactions between moxifloxacin and rifampicin based on pharmacokinetics in vivo in rats.

Moxifloxacin and rifampicin are all the first line options for treatment of active tuberculosis, which are often combined for the treatment of multi-drug resistance pulmonary tuberculosis in clinic. H...

Drug-drug co-crystallization presents a new opportunity for the development of stable vitamins.

Drug-drug co-crystallization could realize combination drugs at a molecular level. Two polymorphic co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polym...

Large-Scale Prediction of Beneficial Drug Combinations Using Drug Efficacy and Target Profiles.

The identification of beneficial drug combinations is a challenging issue in pharmaceutical and clinical research toward combinatorial drug therapy. In the present study, we developed a novel computat...

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