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21:27 EDT 29th April 2016 | BioPortfolio

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Safety monitoring of drug interchangeability

When a brand-name drug is going off patent protection, pharmaceutical or generics companies may file an abbreviated new drug application (ANDA) for approval of a generic drug. As indicated by the US F...

In 2015, First-Of-A Kind Drug Approvals On The Rise

This trend reflected an industry-wide focus on drugs for rare and hard-to-treat diseases. Meanwhile, Gilead's hepatitis C combo drug gets a Food and Drug Administration priority review, a gene-editing...

Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery

Pharmacogenomics, the study of how genes influence drug response, has become an increasingly important technique in modern drug discovery. In this Review, Zhou and colleagues discuss the role of pharm...

Study Indicates Safety of Shingles Pain Drug

NewsAntiviral drug candidate to prevent shingles-related post-herpetic neuralgia pain received positive results from a drug-drug interaction study.

Meeting Announcement: New Approaches for Predicting Drug Toxicity

Ninth Annual New Approaches for Predicting Drug Toxicity Discovering New Models and Integrating Innovative Strategies June 15-16, 2016  |  Boston, MA WorldPreclinicalCongress.com/Drug-Safety-...

FDA Orphan Drug Requests Could Start To Rely More On Non-Profitability Criteria

The Food & Drug Administration may start to see more requests for orphan drug designation based on a little-used criterion under the Orphan Drug Act: a drug that is not expected to recoup the deve...

Drug-Drug Interactions With New HCV Medications

Many patients taking direct acting antivirals (DAA) to treat hepatitis C virus (HCV) are at risk of clinically significant drug-drug interactions (DDIs), new research shows. Reuters Health Informati...

Viral hepatitis: Drug–drug interactions in HCV treatment — the good, the bad and the ugly

A recent study demonstrated that drug–drug interactions are common in patients with HCV and are a challenge for treatment. Identification of these interactions can be time-consuming and complex. A m...

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Do drug seizures predict drug-related emergency department presentations or arrests for drug use and possession?

Direct evidence of the effect of drug seizures on drug use and drug-related harm is fairly sparse. The aim of this study was to see whether seizures of heroin, cocaine and ATS predict the number of pe...

Image-guided drug delivery: preclinical applications and clinical translation.

Image-guided drug delivery refers to the combination of drug targeting and imaging. Preclinically, image-guided drug delivery can be used for several different purposes, including for monitoring biodi...

Drug-drug interactions between moxifloxacin and rifampicin based on pharmacokinetics in vivo in rats.

Moxifloxacin and rifampicin are all the first line options for treatment of active tuberculosis, which are often combined for the treatment of multi-drug resistance pulmonary tuberculosis in clinic. H...

Drug-drug co-crystallization presents a new opportunity for the development of stable vitamins.

Drug-drug co-crystallization could realize combination drugs at a molecular level. Two polymorphic co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polym...

Large-Scale Prediction of Beneficial Drug Combinations Using Drug Efficacy and Target Profiles.

The identification of beneficial drug combinations is a challenging issue in pharmaceutical and clinical research toward combinatorial drug therapy. In the present study, we developed a novel computat...

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