Search Results for "Solubility Of Nystatin"

22:00 EST 22nd December 2014 | BioPortfolio

Original Source: Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin.

Aqueous solubilities of many drugs in current clinical use are very low, necessitating formulations that often present problems for parenteral administration, including toxicities due to the excipients used. Recognizing that pharmacologically active compounds frequently possess amines, we asked whether pyridoxal phosphate (PLP), an inoccuous, water-soluble vitamin, could be utilized to form prodrug-like complexes via the formation of imine or iminium adducts and whether the vitamin would impart solubilizing...

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Polymers for Solubility Enhancement

New chemical entities with poor aqueous solubility require the use of technologies to enable sufficient oral bioavailability of these NCEs following administration.

Hovione and Merrion team on solubility solutions

Hovione has teamed up with delivery tech developer Merrion Pharmaceuticals to provide developers of BCS class III and IV drugs with more solubility enhancement options.

DiLYX OptiSol protein solubility screening kits

OptiSol protein solubility kits from DiLYX are plate-based arrays designed for screening protein stability and buffer optimisation. The kits can be used with proteins from 5 to 300 kDa, identifying fo...

Review of Application of HPMCAS in Hot Melt Extrusion Technology

HPMCAS (Hypromellose Acetate Sucinate) has been used for enteric coating and solubility enhancement for over 30 years. This white paper shows basic data of this polymer for solubility enhancement ...

Tamoxifen Release from EVA Copolymers

As a unique and important controlled-release excipient, EVA was evaluated in the study with selected active pharmaceutical ingredients (API). The API solubility and release profiles were studied u...

The role of LiO2 solubility in O2 reduction in aprotic solvents and its consequences for Li–O2 batteries

The mechanism of O2 reduction in aprotic solvents is important for the operation of Li–O2 batteries but is not well understood. A single unified mechanism is now described that regards previous mode...

AAPS PharmSciTech: Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability

Type: Original PaperUtilization of lipid-based drug delivery systems has recently gained focus for drugs characterized by poor aqueous solubility. The improved aqueous solubility overcomes one of the ...

Pharmaceutical Research: Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Type: Original PaperPurposeTo develop predictive models of apparent solubility (Sapp) of lipophilic drugs in fasted state simulated intestinal fluid (FaSSIF) and aspirated human intestinal fluid (HIF)...

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Nystatin prophylaxis and treatment in severely immunodepressed patients.

Nystatin is sometimes used prophylactically in patients with severe immunodeficiency or in the treatment of fungal infection in such patients, although its effect seems to be equivocal.

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles.

Mesoporous silica nanoparticles (MCM-41) were used as a carrier system to study the influence of surface charge and hydrophobicity on solubility and in-vitro drug release behavior of Griseofulvin, a p...

Cholesterol solubility limit in lipid membranes probed by small angle neutron scattering and MD simulations.

The solubility limits of cholesterol in small unilamellar vesicles made of POPS and POPC were probed using Small Angle Neutron Scattering (SANS) and coarse grained (CG) molecular dynamics (MD) simulat...

Review: Comparative evaluation of various solubility enhancement strategies for furosemide.

Drugs with good solubility exhibit good oral absorption, and subsequently good bioavailability. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancem...

Use of topical lidocaine, diphenhydramine hydrochloride, nystatin, and gabapentin swish in treatment for post-radiation neuropathy and oral mucositis.

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