Search Results for "Solubility Of Nystatin"

10:25 EDT 3rd May 2016 | BioPortfolio

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Non‐monotonic course of protein solubility in aqueous polymer‐salt solutions can be modeled using the sol‐mxDLVO model

Protein purification is often performed using cost‐intensive chromatographic steps. To discover economic alternatives (e.g., crystallization), knowledge on protein solubility as a function of temper...

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the pred...

Spray Drying Capabilities Overcome Solubility Issues

Read more about Spray Drying Capabilities Overcome Solubility IssuesComments

AAPS PharmSciTech: Use of Polyvinyl Alcohol as a Solubility-Enhancing Polymer for Poorly Water Soluble Drug Delivery (Part 1)

Type: Original PaperPolyvinyl alcohol (PVAL) has not been investigated in a binary formulation as a concentration-enhancing polymer owing to its high melting point/high viscosity and poor organic solu...

Pharmaceutical Research: Characterization of Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions

Type: Original PaperPurposeExcipients are essential for solubility enhancing formulations. Hence it is important to understand how additives impact key solution properties, particularly when supersatu...

Solving Solubility Woes

Capsugel’s customized solutions advance challenging compounds

AAPS PharmSciTech: Fusion Method for Solubility and Dissolution Rate Enhancement of Ibuprofen Using Block Copolymer Poloxamer 407

Type: Original PaperAim of current research was to prepare ibuprofen-poloxamer 407 binary mixtures using fusion method and characterize them for their physicochemical and performance properties. Binar...

AAPS PharmSciTech: Studies on Enhancement of Anti-microbial Activity of Pristine MWCNTs Against Pathogens

Type: Original PaperCarbon nanotubes (CNTs), owing to their inherently unique properties in the domain of biomedical sciences including drug delivery, offer an exciting platform to the researchers. Of...

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Preparation and in vitro evaluation of Nystatin micro emulsion based gel.

Nystatin is a polyene antimycotic obtained from Streptomyces noursei used in the treatment of topical and transdermal fungal infection. Nystatin is nearly insoluble in water (

Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate.

In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable pro...

Using MD simulations to calculate how solvents modulate solubility.

Here, our interest is in predicting solubility in general, and we focus particularly on predicting how the solubility of particular solutes is modulated by the solvent environment. Solubility in gener...

Predicting the solubility advantage of amorphous pharmaceuticals - a novel thermodynamic approach.

To improve the solubility and bioavailability of poorly-soluble active pharmaceutical ingredients (APIs), the transformation of crystalline APIs into the amorphous state has often been shown to be adv...

Cocrystal transition points: Role of cocrystal solubility, drug solubility, and solubilizing agents.

In this manuscript we bring together concepts that are relevant to the solubilization and thermodynamic stability of cocrystals in the presence of drug solubilizing agents. Simple equations are derive...

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