Track topics on Twitter Track topics that are important to you
Among advanced solubility enhancement technologies, the most important are solid dispersions and lipid solubilisation
BASF, Abitec and Gattefossé dominate the solubility excipients market but growing demand for tech to enhance API solubility is creating opportunities for smaller suppliers according to new research.
The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the pred...
Type: Original PaperPurposeThe use of hesperidin in the pharmaceutical field is limited by its aqueous insolubility. The effects of natural compounds in tea on the solubility of hesperidin were evalua...
Screening in simulated intestinal fluid could help predict the in vivo effects of bile cholesterol on drug solubility.
Capsugel has acquired a technology platform which uses ionic liquids to enhance the solubility of lipid-based drug delivery systems.
Type: Original PaperThe purpose of this study was to improve the aqueous solubility, dissolution, and pharmacodynamic properties of a BCS class II drug, ezetimibe (Eze) by preparing ternary cyclodextr...
Gains complex solubility expertise
Solubility of mineral trioxide aggregate (MTA) is an important characteristic that affects other properties such as microleakage and biocompatibility. Distilled water (DW) has previously been used for...
The purpose of this study was to conduct a head-to-head comparison of different solubility-enabling formulations, and their consequent solubility-permeability interplay. The low-solubility anticancer ...
To improve the solubility and bioavailability of poorly-soluble active pharmaceutical ingredients (APIs), the transformation of crystalline APIs into the amorphous state has often been shown to be adv...
The solubility limits of cholesterol in small unilamellar vesicles made of POPS and POPC were probed using Small Angle Neutron Scattering (SANS) and coarse grained (CG) molecular dynamics (MD) simulat...
Introduction: The aim of this study was to evaluate the effect of different mixing techniques on the pH and solubility of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM). Methods a...