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Search Results for "Solubility Of Nystatin"

21:51 EDT 18th April 2014 | BioPortfolio

Original Source: Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin.

Aqueous solubilities of many drugs in current clinical use are very low, necessitating formulations that often present problems for parenteral administration, including toxicities due to the excipients used. Recognizing that pharmacologically active compounds frequently possess amines, we asked whether pyridoxal phosphate (PLP), an inoccuous, water-soluble vitamin, could be utilized to form prodrug-like complexes via the formation of imine or iminium adducts and whether the vitamin would impart solubilizing...

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Trust the Originator: HPMCAS Technology

HPMCAS (Hypromellose Acetate Sucinate) has been used for enteric coating and solubility enhancement for over 30 years. The white paper shows basic data of this polymer for solubility enhancement u...

AAPS PharmSciTech: SN-38-Cyclodextrin Complexation and Its Influence on the Solubility, Stability, and In Vitro Anticancer Activity Against Ovarian Cancer

Type: Original PaperSN-38, an active metabolite of irinotecan, is up to 1,000-fold more potent than irinotecan. But the clinical use of SN-38 is limited by its extreme hydrophobicity and instability a...

AAPS PharmSciTech: Physicochemical Characterization of 9-Aminocamptothecin in Aqueous Solutions

Type: Original PaperThe present manuscript provides a detailed physicochemical and thermodynamic characterization of 9-aminocamptothecin (9AC) which can be used as a tool to develop novel formulation...

AAPS PharmSciTech: Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Type: Original PaperThe objective of this research was to investigate physicochemical properties of an active pharmaceutical ingredient (API) that influence cyclodextrin complexation through experimen...

Solubility of recombinant Src homology 2 domains expressed in E. coli can be predicted by TANGO

Background: Signalling proteins often contain several well defined and conserved protein domains. Structural analyses of such domains by nuclear magnetic spectroscopy or X-ray crystallography may grea...

Pharmaceutical Research: A Novel Method for Determining the Solubility of Small Molecules in Aqueous Media and Polymer Solvent Systems Using Solution Calorimetry

Type: Original PaperPurposeTo explore the application of solution calorimetry for measuring drug solubility in experimentally challenging situations while providing additional information on the physi...

Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids

Background: O. stamineus is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value. This study sought to prepare nano...

Pharmaceutical Research: Investigations on the Viscoelastic Performance of Pressure Sensitive Adhesives in Drug-in-Adhesive Type Transdermal Films

Type: Original PaperPurposeWe aimed to investigate the effect of solubility parameter and drug concentration on the rheological behaviour of drug-in-adhesive films intended for transdermal application...

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Nystatin and killer toxin sensitivity of free and immobilizedSaccharomyces cerevisiae.

The inhibitory effect of nystatin and killer toxin on the growth of free and covalently-immobilizedSaccharomyces cerevisiae cells was studied. The resistance of immobilized cells to both agents was ac...

Chemiluminescent Nitrogen Detection (CLND) to Measure Kinetic Aqueous Solubility.

Solubility is the dose-limiting property for in vitro studies, and therefore is a critical physicochemical property to measure in drug discovery. Solubility data can be used to guide lead optimization...

Characterization of olanzapine-solid dispersions.

To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Dru...

Development of microemulsion for solubility enhancement of clopidogrel.

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprote...

Release of hydrolytic enzymes from the cell walls of intact and disrupted carrot callus tissue.

The effect of ionic strength and pH on the solubility of acid invertase (E.C. 3.2.1.26.) and α-glucosidase (E.C. 3.2.1.20.) from carrot Daucus carota L. tissue cultures is presented. The action of th...

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