Search Results for "Solubility Of Nystatin"

19:19 EST 25th January 2015 | BioPortfolio

Original Source: Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin.

Aqueous solubilities of many drugs in current clinical use are very low, necessitating formulations that often present problems for parenteral administration, including toxicities due to the excipients used. Recognizing that pharmacologically active compounds frequently possess amines, we asked whether pyridoxal phosphate (PLP), an inoccuous, water-soluble vitamin, could be utilized to form prodrug-like complexes via the formation of imine or iminium adducts and whether the vitamin would impart solubilizing...

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Polymers for Solubility Enhancement

New chemical entities with poor aqueous solubility require the use of technologies to enable sufficient oral bioavailability of these NCEs following administration.

DiLYX OptiSol protein solubility screening kits

OptiSol protein solubility kits from DiLYX are plate-based arrays designed for screening protein stability and buffer optimisation. The kits can be used with proteins from 5 to 300 kDa, identifying fo...

Review of Application of HPMCAS in Hot Melt Extrusion Technology

HPMCAS (Hypromellose Acetate Sucinate) has been used for enteric coating and solubility enhancement for over 30 years. This white paper shows basic data of this polymer for solubility enhancement ...

Tamoxifen Release from EVA Copolymers

As a unique and important controlled-release excipient, EVA was evaluated in the study with selected active pharmaceutical ingredients (API). The API solubility and release profiles were studied u...

Pharmaceutical Research: NMR Spectroscopic and Quantum Mechanical Analyses of Enhanced Solubilization of Hesperidin by Theasinensin A

Type: Original PaperPurposeThe use of hesperidin in the pharmaceutical field is limited by its aqueous insolubility. The effects of natural compounds in tea on the solubility of hesperidin were evalua...

Capsugel buys ionic liquid tech IP to enhance lipid-based drug solubility

Capsugel has acquired a technology platform which uses ionic liquids to enhance the solubility of lipid-based drug delivery systems.

The role of LiO2 solubility in O2 reduction in aprotic solvents and its consequences for Li–O2 batteries

The mechanism of O2 reduction in aprotic solvents is important for the operation of Li–O2 batteries but is not well understood. A single unified mechanism is now described that regards previous mode...

AAPS PharmSciTech: A Menthol-Based Solid Dispersion Technique for Enhanced Solubility and Dissolution of Sulfamethoxazole from an Oral Tablet Matrix

Type: Original PaperA menthol-based solid dispersion was designed to improve the intrinsic solubility of the poorly soluble sulfamethoxazole- a class II drug molecule of Biopharmaceutics Classificatio...

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Nystatin prophylaxis and treatment in severely immunodepressed patients.

Nystatin is sometimes used prophylactically in patients with severe immunodeficiency or in the treatment of fungal infection in such patients, although its effect seems to be equivocal.

A new simulated plasma for assessing the solubility of mineral trioxide aggregate.

Solubility of mineral trioxide aggregate (MTA) is an important characteristic that affects other properties such as microleakage and biocompatibility. Distilled water (DW) has previously been used for...

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles.

Mesoporous silica nanoparticles (MCM-41) were used as a carrier system to study the influence of surface charge and hydrophobicity on solubility and in-vitro drug release behavior of Griseofulvin, a p...

Cholesterol solubility limit in lipid membranes probed by small angle neutron scattering and MD simulations.

The solubility limits of cholesterol in small unilamellar vesicles made of POPS and POPC were probed using Small Angle Neutron Scattering (SANS) and coarse grained (CG) molecular dynamics (MD) simulat...

Review: Comparative evaluation of various solubility enhancement strategies for furosemide.

Drugs with good solubility exhibit good oral absorption, and subsequently good bioavailability. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancem...

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