Search Results for "Solubility Of Nystatin"

12:12 EDT 30th July 2015 | BioPortfolio

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Low solubility concern is driving market for solubility enhancement excipients, finds report

Among advanced solubility enhancement technologies, the most important are solid dispersions and lipid solubilisation

Big firms dominate solubility sector but demand creating space for small players, says Kline & Co

BASF, Abitec and Gattefossé dominate the solubility excipients market but growing demand for tech to enhance API solubility is creating opportunities for smaller suppliers according to new research.

AAPS PharmSciTech: pH-Dependent Solubility and Dissolution Behavior of Carvedilol—Case Example of a Weakly Basic BCS Class II Drug

Type: Original PaperThe objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characteri...

Pharmaceutical Research: Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

Type: Original PaperPurposeCompound solubility serves as a surrogate indicator of oral biopharmaceutical performance. Between infancy and adulthood, marked compositional changes in gastrointestinal (G...

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the pred...

Hovione upping spray drying capacity to support rise in low solubility drugs

A new unit will up Hovione’s spray drying capacity 20% as it predicts a surge in demand for such a service in overcoming drug solubility issues.

In vitro prediction of drug solubility with fasted-state simulated intestinal fluid (FaSSIF) with cholesterol (FaSSIF-C)

Screening in simulated intestinal fluid could help predict the in vivo effects of bile cholesterol on drug solubility.

AAPS PharmSciTech: Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances

Type: Original PaperThe purpose of this study was to improve the aqueous solubility, dissolution, and pharmacodynamic properties of a BCS class II drug, ezetimibe (Eze) by preparing ternary cyclodextr...

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A new simulated plasma for assessing the solubility of mineral trioxide aggregate.

Solubility of mineral trioxide aggregate (MTA) is an important characteristic that affects other properties such as microleakage and biocompatibility. Distilled water (DW) has previously been used for...

Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility-Permeability Interplay.

The purpose of this study was to conduct a head-to-head comparison of different solubility-enabling formulations, and their consequent solubility-permeability interplay. The low-solubility anticancer ...

Predicting the solubility advantage of amorphous pharmaceuticals - a novel thermodynamic approach.

To improve the solubility and bioavailability of poorly-soluble active pharmaceutical ingredients (APIs), the transformation of crystalline APIs into the amorphous state has often been shown to be adv...

Cocrystal transition points: Role of cocrystal solubility, drug solubility, and solubilizing agents.

In this manuscript we bring together concepts that are relevant to the solubilization and thermodynamic stability of cocrystals in the presence of drug solubilizing agents. Simple equations are derive...

The impact of structural modification of 1,2,4-thiadiazole derivatives on thermodynamics of solubility and hydration processes.

The influence of a structural modification on thermodynamic aspects of solubility and hydration processes of 1,2,4-thiadiazole drug-like compounds was investigated. A substitution in the phenyl ring o...

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