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Search Results for "Solubility Of Nystatin"

00:51 EST 7th February 2016 | BioPortfolio

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AAPS PharmSciTech: pH-Dependent Solubility and Dissolution Behavior of Carvedilol—Case Example of a Weakly Basic BCS Class II Drug

Type: Original PaperThe objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characteri...

Non‐monotonic course of protein solubility in aqueous polymer‐salt solutions can be modeled using the sol‐mxDLVO model

Protein purification is often performed using cost‐intensive chromatographic steps. To discover economic alternatives (e.g., crystallization), knowledge on protein solubility as a function of temper...

Pharmaceutical Research: Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

Type: Original PaperPurposeCompound solubility serves as a surrogate indicator of oral biopharmaceutical performance. Between infancy and adulthood, marked compositional changes in gastrointestinal (G...

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the pred...

Echo's cannabis API delivery formulation could aid low solubility drugs

A drug delivery platform which increased the bioavailability of a cannabis-based drug candidate 30% could be used to boost solubility of other APIs, says Echo Pharmaceuticals.

The Powder Room - Improving Drug Water Solubility

In collaboration with Ghent University, Laboratoria Smeets has developed a new granulating technology capable of significantly improving drug water solubility. Managing director Dr Jef Verplaetse expl...

Overexpression of AtVIT1 Increases Accumulation of Iron in Cassava

Iron uptake in plants is limited due to its low solubility in neutral or alkaline soils. This is why plants rely on rhizosphere acidification to increase iron solubility. AtVIT1 gene from Arabidopsis ...

AAPS PharmSciTech: Effervescence Assisted Fusion Technique to Enhance the Solubility of Drugs

Type: Brief CommunicationThe solubility of five poorly soluble drugs was enhanced by using an effervescence assisted solid dispersion (EASD) technique. EASDs were prepared by using modified fusion met...

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Preparation and in vitro evaluation of Nystatin micro emulsion based gel.

Nystatin is a polyene antimycotic obtained from Streptomyces noursei used in the treatment of topical and transdermal fungal infection. Nystatin is nearly insoluble in water (

Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate.

In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable pro...

Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility-Permeability Interplay.

The purpose of this study was to conduct a head-to-head comparison of different solubility-enabling formulations, and their consequent solubility-permeability interplay. The low-solubility anticancer ...

Predicting the solubility advantage of amorphous pharmaceuticals - a novel thermodynamic approach.

To improve the solubility and bioavailability of poorly-soluble active pharmaceutical ingredients (APIs), the transformation of crystalline APIs into the amorphous state has often been shown to be adv...

Cocrystal transition points: Role of cocrystal solubility, drug solubility, and solubilizing agents.

In this manuscript we bring together concepts that are relevant to the solubilization and thermodynamic stability of cocrystals in the presence of drug solubilizing agents. Simple equations are derive...

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