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Search Results for "Solubility Of Nystatin"

13:27 EDT 22nd July 2014 | BioPortfolio

Original Source: Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin.

Aqueous solubilities of many drugs in current clinical use are very low, necessitating formulations that often present problems for parenteral administration, including toxicities due to the excipients used. Recognizing that pharmacologically active compounds frequently possess amines, we asked whether pyridoxal phosphate (PLP), an inoccuous, water-soluble vitamin, could be utilized to form prodrug-like complexes via the formation of imine or iminium adducts and whether the vitamin would impart solubilizing...

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Hovione and Merrion team on solubility solutions

Hovione has teamed up with delivery tech developer Merrion Pharmaceuticals to provide developers of BCS class III and IV drugs with more solubility enhancement options.

Trust the Originator: HPMCAS Technology

HPMCAS (Hypromellose Acetate Sucinate) has been used for enteric coating and solubility enhancement for over 30 years. The white paper shows basic data of this polymer for solubility enhancement u...

AAPS PharmSciTech: SN-38-Cyclodextrin Complexation and Its Influence on the Solubility, Stability, and In Vitro Anticancer Activity Against Ovarian Cancer

Type: Original PaperSN-38, an active metabolite of irinotecan, is up to 1,000-fold more potent than irinotecan. But the clinical use of SN-38 is limited by its extreme hydrophobicity and instability a...

AAPS PharmSciTech: A 5,7-Dimethoxyflavone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex with Anti-Butyrylcholinesterase Activity

Type: Original PaperThis study aimed to improve the water solubility of 5,7-dimethoxyflavone (5,7-DMF) isolated from Kaempferia parviflora by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβ-CD...

AAPS PharmSciTech: Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Type: Original PaperThe objective of this research was to investigate physicochemical properties of an active pharmaceutical ingredient (API) that influence cyclodextrin complexation through experimen...

AAPS PharmSciTech: The Effect of Polysorbate 20 on Solubility and Stability of Candesartan Cilexetil in Dissolution Media

Type: Original PaperThe addition of polysorbate 20 (T20) is required to achieve “sink” conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate 20 (0.35%–0.7...

Pharmaceutical Research: A Novel Method for Determining the Solubility of Small Molecules in Aqueous Media and Polymer Solvent Systems Using Solution Calorimetry

Type: Original PaperPurposeTo explore the application of solution calorimetry for measuring drug solubility in experimentally challenging situations while providing additional information on the physi...

Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids

Background: O. stamineus is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value. This study sought to prepare nano...

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Nystatin and killer toxin sensitivity of free and immobilizedSaccharomyces cerevisiae.

The inhibitory effect of nystatin and killer toxin on the growth of free and covalently-immobilizedSaccharomyces cerevisiae cells was studied. The resistance of immobilized cells to both agents was ac...

Chemiluminescent Nitrogen Detection (CLND) to Measure Kinetic Aqueous Solubility.

Solubility is the dose-limiting property for in vitro studies, and therefore is a critical physicochemical property to measure in drug discovery. Solubility data can be used to guide lead optimization...

Characterization of olanzapine-solid dispersions.

To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Dru...

Use of topical lidocaine, diphenhydramine hydrochloride, nystatin, and gabapentin swish in treatment for post-radiation neuropathy and oral mucositis.

Review: Comparative evaluation of various solubility enhancement strategies for furosemide.

Drugs with good solubility exhibit good oral absorption, and subsequently good bioavailability. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancem...

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