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04:54 EDT 27th September 2016 | BioPortfolio

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Vitamin E

Naturally occurring vitamin E exists in eight chemical forms (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) that have varying levels of biological act...

Follicle stimulating hormone FSH

Follicle-stimulating hormone (FSH) now has become an established means of ovulation induction (OI) as part of assisted reproductive technology (ART). FSH is used to induce development of multiple foll...

Oxford

Located in south-east England, Oxford is home to a world-famous academic institution, Oxford University, but is addition to this it hosts over 100 high-quality biotechnology companies with in 10 mil...

Herpes simplex virus HSV 1 HSV 2 HHV 1 HHV 2

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 (HHV-1 and -2), are two members of the herpes virus family that infect humans. HSV-1 and HSV-2 cause the vira...

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The AAPS Journal: Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation

Type: Original Paper3-Acetyl-11-keto-β-boswellic acid (AKBA) and 11-keto-β-boswellic acid (KBA) are widely used in the clinic as anti-inflammatory drugs. However, these drugs have the poor bioavaila...

Combinatorial metabolic engineering of industrial Gluconobacter oxydans DSM2343 for boosting 5-keto-D-gluconic acid accumulation

L-(+)-tartaric acid (L-TA) is an important organic acid, which is produced from the cream of tartar or stereospecific hydrolysis of the cis-epoxysuccinate. The former method is limited by the availabi...

Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy

Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis. Abiraterone is metaboli...

Should all prescriptions be free?

10 August 2016: Chair of the Royal Pharmaceutical Society’s (RPS) English Pharmacy board, Sandra Gidley, spoke to BBC Radio Stoke about prescription charges in England. “It’s a medical lottery i...

Extreme makeover: Engineering the activity of a thermostable alcohol dehydrogenase (AdhD) from Pyrococcus furiosus

Alcohol dehydrogenase D (AdhD) is a monomeric thermostable alcohol dehydrogenase from the aldo‐keto reductase (AKR) superfamily of proteins. We have been exploring various strategies of engineering ...

Tesco to offer free fruit to children while parents shop – BT.com

BT.comTesco to offer free fruit to children while parents shopBT.comTesco is to offer free fruit to children while their parents shop in more than 800 of its stores after a successful trial. 0. Share ...

Hey Drivers: Hands-Free Cellphones Not Risk-Free

WEDNESDAY, June 8, 2016 -- Talking on a hands-free phone while driving may be just as distracting and dangerous as using a hand-held phone, according to a new study. In lab-based tests, British resear...

Diet Doc Cautions That Gluten-Free Dieting Alone Does Not Contribute to Weight Loss

PORTLAND, ME--(Marketwired - September 15, 2016) -Despite the growing popularity of gluten-free diets and celebrity endorsements of the merits of a gluten-free diet Read more...

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Catalyst-Free Singlet Oxygen-Promoted Decarboxylative Amidation of α-Keto Acids with Free Amines.

A novel catalyst-free decarboxylative amidation of α-keto acids with amines under mild conditions has been developed. Advantages of the new protocol include avoidance of metal catalysts and high leve...

Biotechnological production of alpha-keto acids: Current status and perspectives.

Alpha-keto (α-keto) acids are used widely in feeds, food additives, pharmaceuticals, and in chemical synthesis processes. Although most α-keto acids are currently produced by chemical synthesis, the...

Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of -Keto Sulfides and Sulfones.

Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of -keto sulfides and -keto sulfones. In the paper, the tran...

Catalyst-Free Insertion of Sulfoxonium Ylides into Aryl Thiols. A Direct Preparation of β-Keto Thioethers.

Insertion of sulfoxonium ylides into the S-H bond of aryl thiols without the need for a catalyst is demonstrated, furnishing β-keto thioethers in excellent yield in most cases. The method overcomes t...

Chemoselective Conversion from α-Hydroxy Acids to α-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation.

The chemoselective oxidation of α-hydroxy acids to α-keto acids catalyzed by 2-azaadamantane N-oxyl (AZADO), a nitroxyl radical catalyst, is described. Although α-keto acids are labile and can easi...

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